ENSG00000187840


Homo sapiens

Features
Gene ID: ENSG00000187840
  
Biological name :EIF4EBP1
  
Synonyms : EIF4EBP1 / eukaryotic translation initiation factor 4E binding protein 1 / Q13541
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: 1
Band: p11.23
Gene start: 38030341
Gene end: 38060365
  
Corresponding Affymetrix probe sets: 221539_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000340691
NCBI entrez gene - 1978     See in Manteia.
OMIM - 602223
RefSeq - NM_004095
RefSeq Peptide - NP_004086
swissprot - Q13541
Ensembl - ENSG00000187840
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eif4ebp1ENSDARG00000043608Danio rerio
 EIF4EBP1ENSGALG00000003205Gallus gallus
 Q60876ENSMUSG00000031490Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q13542 / EIF4EBP2 / eukaryotic translation initiation factor 4E binding protein 2ENSG0000014873057
O60516 / EIF4EBP3 / eukaryotic translation initiation factor 4E binding protein 3ENSG0000024305647


Protein motifs (from Interpro)
Interpro ID Name
 IPR008606  Eukaryotic translation initiation factor 4E binding
 IPR037582  Eukaryotic translation initiation factor 4E-binding protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IMP
 biological_processGO:0002192 IRES-dependent translational initiation of linear mRNA IEA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0008286 insulin receptor signaling pathway IEA
 biological_processGO:0017148 negative regulation of translation IEA
 biological_processGO:0031929 TOR signaling IDA
 biological_processGO:0045931 positive regulation of mitotic cell cycle IMP
 biological_processGO:0045947 negative regulation of translational initiation IDA
 biological_processGO:0071549 cellular response to dexamethasone stimulus IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008190 eukaryotic initiation factor 4E binding IDA
 molecular_functionGO:0030371 translation repressor activity IDA


Pathways (from Reactome)
Pathway description
mTORC1-mediated signalling
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000151247 EIF4E / P06730 / eukaryotic translation initiation factor 4E  / complex
 ENSG00000198793 MTOR / P42345 / mechanistic target of rapamycin kinase  / reaction






 

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