ENSG00000188554


Homo sapiens

Features
Gene ID: ENSG00000188554
  
Biological name :NBR1
  
Synonyms : NBR1 / NBR1, autophagy cargo receptor / Q14596
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q21.31
Gene start: 43170481
Gene end: 43211689
  
Corresponding Affymetrix probe sets: 1568856_at (Human Genome U133 Plus 2.0 Array)   1568857_a_at (Human Genome U133 Plus 2.0 Array)   201383_s_at (Human Genome U133 Plus 2.0 Array)   201384_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000467816
Ensembl peptide - ENSP00000343479
Ensembl peptide - ENSP00000437545
Ensembl peptide - ENSP00000466071
Ensembl peptide - ENSP00000466667
NCBI entrez gene - 4077     See in Manteia.
OMIM - 166945
RefSeq - XM_017024644
RefSeq - NM_001291571
RefSeq - NM_001291572
RefSeq - NM_005899
RefSeq - NM_031862
RefSeq - XM_006721903
RefSeq - XM_011524813
RefSeq - XM_017024642
RefSeq - XM_017024643
RefSeq Peptide - NP_005890
RefSeq Peptide - NP_114068
RefSeq Peptide - NP_001278500
RefSeq Peptide - NP_001278501
swissprot - Q14596
swissprot - A0A0C4DGP6
swissprot - B7Z5R6
swissprot - A0A024R1V3
Ensembl - ENSG00000188554
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nbr1aENSDARG00000077297Danio rerio
 nbr1bENSDARG00000078772Danio rerio
 NBR1ENSGALG00000002765Gallus gallus
 Nbr1ENSMUSG00000017119Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000270  PB1 domain
 IPR000433  Zinc finger, ZZ-type
 IPR009060  UBA-like superfamily
 IPR015940  Ubiquitin-associated domain
 IPR032350  Next to BRCA1, central domain
 IPR033513  Next to BRCA1 gene 1 protein
 IPR034852  NBR1, PB1 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016236 macroautophagy IDA
 biological_processGO:0030500 regulation of bone mineralization ISS
 biological_processGO:0032872 regulation of stress-activated MAPK cascade ISS
 biological_processGO:0045668 negative regulation of osteoblast differentiation ISS
 biological_processGO:0051259 protein complex oligomerization IDA
 cellular_componentGO:0000407 phagophore assembly site IBA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005770 late endosome ISS
 cellular_componentGO:0005776 autophagosome ISS
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0016604 nuclear body IDA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031430 M band IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0043130 ubiquitin binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051019 mitogen-activated protein kinase binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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