ENSG00000188613


Homo sapiens

Features
Gene ID: ENSG00000188613
  
Biological name :NANOS1
  
Synonyms : NANOS1 / nanos C2HC-type zinc finger 1 / Q8WY41
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: 1
Band: q26.11
Gene start: 119029716
Gene end: 119033732
  
Corresponding Affymetrix probe sets: 228523_at (Human Genome U133 Plus 2.0 Array)   228526_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000345924
Ensembl peptide - ENSP00000393275
NCBI entrez gene - 340719     See in Manteia.
OMIM - 608226
RefSeq - NM_199461
RefSeq Peptide - NP_955631
swissprot - Q5T9H5
swissprot - Q8WY41
Ensembl - ENSG00000188613
  
Related genetic diseases (OMIM): 615413 - Spermatogenic failure 12, 615413
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 E7FDB3ENSDARG00000109337Danio rerio
 NANOS1ENSGALG00000027980Gallus gallus
 Nanos1ENSMUSG00000072437Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NANOS3 / P60323 / nanos C2HC-type zinc finger 3ENSG0000018755616
NANOS2 / P60321 / nanos C2HC-type zinc finger 2ENSG0000018842516


Protein motifs (from Interpro)
Interpro ID Name
 IPR008705  Nanos/Xcat2
 IPR024161  Zinc finger, nanos-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth IEA
 biological_processGO:0001894 tissue homeostasis IEA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0010608 posttranscriptional regulation of gene expression IEA
 biological_processGO:0010631 epithelial cell migration IDA
 biological_processGO:0016477 cell migration IDA
 biological_processGO:0017148 negative regulation of translation IDA
 biological_processGO:0098749 cerebellar neuron development IEA
 biological_processGO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0030371 translation repressor activity ISS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000006 Autosomal dominant inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele." [HPO:curators]
Show

 HP:0000027 Azoospermia 
Show

 HP:0000789 Infertility 
Show

 HP:0000837 Elevated gonadotropins 
Show

 HP:0008734 Decreased testicular size 
Show

 HP:0011961 Non-obstructive azoospermia "Absence of any measurable level of sperm in his semen, resulting from a defect in the production of spermatozoa in the testes. Can be differentiated from obstructive azoospermia on the basis of testicular biopsy." [HPO:probinson, pmid:20514278]
Show

 HP:0011962 Obstructive azoospermia "Absence of any measurable level of sperm in his semen, resulting from post-testicular obstruction or retrograde ejaculation. Can be differentiated from obstructive azoospermia on the basis of testicular biopsy." [HPO:probinson, pmid:20514278]
Show

 HP:0012205 Globozoospermia "Any structural anomaly of the acrosome resulting in a round sperm head." [HPO:probinson, MP:0002686]
Show

 HP:0012863 Abnormal male germ cell morphology "A structural anomaly of a male reproductive cell." [HPO:probinson]
Show

 HP:0012868 Sperm tail anomaly "A structural abnormality of the sperm tail." [HPO:probinson, pmid:22198630]
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr