ENSG00000196277


Homo sapiens

Features
Gene ID: ENSG00000196277
  
Biological name :GRM7
  
Synonyms : glutamate metabotropic receptor 7 / GRM7 / Q14831
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: p26.1
Gene start: 6770001
Gene end: 7741533
  
Corresponding Affymetrix probe sets: 207548_at (Human Genome U133 Plus 2.0 Array)   217008_s_at (Human Genome U133 Plus 2.0 Array)   241049_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000404161
Ensembl peptide - ENSP00000419835
Ensembl peptide - ENSP00000417536
Ensembl peptide - ENSP00000412329
Ensembl peptide - ENSP00000405194
Ensembl peptide - ENSP00000350348
Ensembl peptide - ENSP00000373986
Ensembl peptide - ENSP00000373987
Ensembl peptide - ENSP00000384585
Ensembl peptide - ENSP00000393799
Ensembl peptide - ENSP00000395035
NCBI entrez gene - 2917     See in Manteia.
OMIM - 604101
RefSeq - XM_017006273
RefSeq - NM_000844
RefSeq - NM_181874
RefSeq - XM_017006272
RefSeq Peptide - NP_870989
RefSeq Peptide - NP_000835
swissprot - Q14831
swissprot - C9JU97
swissprot - A0A0A0MSC3
swissprot - C9JMT3
swissprot - F8WCR9
swissprot - F8WAW6
swissprot - H7C3K2
Ensembl - ENSG00000196277
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CR974456.1ENSDARG00000114852Danio rerio
 FO904977.1ENSDARG00000100267Danio rerio
 GRM7ENSGALG00000037841Gallus gallus
 Grm7ENSMUSG00000056755Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GRM8 / O00222 / glutamate metabotropic receptor 8ENSG0000017960373
GRM4 / Q14833 / glutamate metabotropic receptor 4ENSG0000012449369
GRM6 / O15303 / glutamate metabotropic receptor 6ENSG0000011326263
GRM2 / Q14416 / glutamate metabotropic receptor 2ENSG0000016408243
GRM3 / Q14832 / glutamate metabotropic receptor 3ENSG0000019882243
GRM5 / P41594 / glutamate metabotropic receptor 5ENSG0000016895940
GRM1 / Q13255 / glutamate metabotropic receptor 1ENSG0000015282239
GPRC6A / Q5T6X5 / G protein-coupled receptor class C group 6 member AENSG0000017361222
Q8TE23 / TAS1R2 / taste 1 receptor member 2ENSG0000017900222
Q7RTX1 / TAS1R1 / taste 1 receptor member 1ENSG0000017366221
Q7RTX0 / TAS1R3 / taste 1 receptor member 3ENSG0000016996220


Protein motifs (from Interpro)
Interpro ID Name
 IPR000162  GPCR, family 3, metabotropic glutamate receptor
 IPR000337  GPCR, family 3
 IPR001828  Receptor, ligand binding region
 IPR001883  GPCR, family 3, metabotropic glutamate receptor 7
 IPR011500  GPCR, family 3, nine cysteines domain
 IPR017978  GPCR family 3, C-terminal
 IPR017979  GPCR, family 3, conserved site
 IPR028082  Periplasmic binding protein-like I


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway IDA
 biological_processGO:0007268 chemical synaptic transmission IDA
 biological_processGO:0007605 sensory perception of sound IMP
 biological_processGO:0014050 negative regulation of glutamate secretion ISS
 biological_processGO:0031279 regulation of cyclase activity IEA
 biological_processGO:0050896 response to stimulus IEA
 biological_processGO:0051966 regulation of synaptic transmission, glutamatergic IBA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0005938 cell cortex IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon ISS
 cellular_componentGO:0030425 dendrite IDA
 cellular_componentGO:0032279 asymmetric synapse ISS
 cellular_componentGO:0042734 presynaptic membrane IBA
 cellular_componentGO:0043198 dendritic shaft ISS
 cellular_componentGO:0043235 receptor complex IDA
 cellular_componentGO:0045211 postsynaptic membrane ISS
 cellular_componentGO:0048786 presynaptic active zone ISS
 molecular_functionGO:0001642 group III metabotropic glutamate receptor activity IDA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0005246 calcium channel regulator activity IBA
 molecular_functionGO:0008066 glutamate receptor activity IDA
 molecular_functionGO:0010855 adenylate cyclase inhibitor activity IDA
 molecular_functionGO:0070905 serine binding IDA


Pathways (from Reactome)
Pathway description
G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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