ENSG00000196468


Homo sapiens

Features
Gene ID: ENSG00000196468
  
Biological name :FGF16
  
Synonyms : FGF16 / fibroblast growth factor 16 / O43320
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: 1
Band: q21.1
Gene start: 77447405
Gene end: 77457278
  
Corresponding Affymetrix probe sets: 221374_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000399324
NCBI entrez gene - 8823     See in Manteia.
OMIM - 300827
RefSeq - NM_003868
RefSeq Peptide - NP_003859
swissprot - O43320
Ensembl - ENSG00000196468
  
Related genetic diseases (OMIM): 309630 - Metacarpal 4-5 fusion, 309630
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fgf16ENSDARG00000042233Danio rerio
 FGF16ENSGALG00000007806Gallus gallus
 Fgf16ENSMUSG00000031230Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FGF9 / P31371 / fibroblast growth factor 9ENSG0000010267870
FGF20 / Q9NP95 / fibroblast growth factor 20ENSG0000007857964
FGF3 / P11487 / fibroblast growth factor 3ENSG0000018689535
FGF5 / P12034 / fibroblast growth factor 5ENSG0000013867533
FGF10 / O15520 / fibroblast growth factor 10ENSG0000007019331
FGF22 / Q9HCT0 / fibroblast growth factor 22ENSG0000007038830
FGF7 / P21781 / fibroblast growth factor 7ENSG0000014028530
FGF11 / Q92914 / fibroblast growth factor 11ENSG0000016195830
FGF4 / P08620 / fibroblast growth factor 4ENSG0000007538829
FGF14 / Q92915 / fibroblast growth factor 14ENSG0000010246629
FGF6 / P10767 / fibroblast growth factor 6ENSG0000011124129
FGF12 / P61328 / fibroblast growth factor 12ENSG0000011427929
FGF13 / Q92913 / fibroblast growth factor 13ENSG0000012968229


Protein motifs (from Interpro)
Interpro ID Name
 IPR002209  Fibroblast growth factor family
 IPR008996  Cytokine IL1/FGF
 IPR028285  Fibroblast growth factor 16


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway TAS
 biological_processGO:0009266 response to temperature stimulus TAS
 biological_processGO:0009887 animal organ morphogenesis TAS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0036092 phosphatidylinositol-3-phosphate biosynthetic process IEA
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling TAS
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0070349 positive regulation of brown fat cell proliferation IEA
 biological_processGO:2000546 positive regulation of endothelial cell chemotaxis to fibroblast growth factor IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space TAS
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity TAS
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005104 fibroblast growth factor receptor binding IEA
 molecular_functionGO:0008083 growth factor activity TAS
 molecular_functionGO:0016303 1-phosphatidylinositol-3-kinase activity TAS
 molecular_functionGO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS


Pathways (from Reactome)
Pathway description
PI3K Cascade
PIP3 activates AKT signaling
Signaling by activated point mutants of FGFR3
FGFR4 ligand binding and activation
FGFR3c ligand binding and activation
FGFR2c ligand binding and activation
FGFR3 mutant receptor activation
Activated point mutants of FGFR2
Constitutive Signaling by Aberrant PI3K in Cancer
Phospholipase C-mediated cascade; FGFR2
Phospholipase C-mediated cascade; FGFR3
Phospholipase C-mediated cascade; FGFR4
PI-3K cascade:FGFR2
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
SHC-mediated cascade:FGFR3
FRS-mediated FGFR3 signaling
PI-3K cascade:FGFR3
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
PI-3K cascade:FGFR4
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
Signaling by FGFR2 in disease
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Signaling by FGFR3 point mutants in cancer


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0005867 Fused fourth and fifth metacarpals 
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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