ENSG00000197323


Homo sapiens

Features
Gene ID: ENSG00000197323
  
Biological name :TRIM33
  
Synonyms : Q9UPN9 / TRIM33 / tripartite motif containing 33
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p13.2
Gene start: 114392777
Gene end: 114511160
  
Corresponding Affymetrix probe sets: 210266_s_at (Human Genome U133 Plus 2.0 Array)   212435_at (Human Genome U133 Plus 2.0 Array)   212436_at (Human Genome U133 Plus 2.0 Array)   214815_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000351250
Ensembl peptide - ENSP00000358556
Ensembl peptide - ENSP00000402333
NCBI entrez gene - 51592     See in Manteia.
OMIM - 605769
RefSeq - XM_017001453
RefSeq - NM_015906
RefSeq - NM_033020
RefSeq - XM_005270936
RefSeq - XM_005270937
RefSeq - XM_011541568
RefSeq - XM_017001452
RefSeq Peptide - NP_056990
RefSeq Peptide - NP_148980
swissprot - Q9UPN9
swissprot - H0Y612
Ensembl - ENSG00000197323
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 trim33ENSDARG00000016181Danio rerio
 TRIM33ENSGALG00000001976Gallus gallus
 Trim33ENSMUSG00000033014Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O15164 / TRIM24 / tripartite motif containing 24ENSG0000012277948
O15016 / TRIM66 / tripartite motif containing 66ENSG0000016643628
Q13263 / TRIM28 / tripartite motif containing 28ENSG0000013072624
TRIM2 / Q9C040 / tripartite motif containing 2ENSG0000010965411
TRIM3 / O75382 / tripartite motif containing 3ENSG0000011017111
Q2Q1W2 / TRIM71 / tripartite motif containing 71ENSG0000020655711
Q9H8W5 / TRIM45 / tripartite motif containing 45ENSG0000013425310
Q9BRZ2 / TRIM56 / tripartite motif containing 56ENSG0000016987110


Protein motifs (from Interpro)
Interpro ID Name
 IPR000315  B-box-type zinc finger
 IPR001487  Bromodomain
 IPR001841  Zinc finger, RING-type
 IPR001965  Zinc finger, PHD-type
 IPR003649  B-box, C-terminal
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017907  Zinc finger, RING-type, conserved site
 IPR019786  Zinc finger, PHD-type, conserved site
 IPR019787  Zinc finger, PHD-finger
 IPR027370  RING-type zinc-finger, LisH dimerisation motif
 IPR036427  Bromodomain-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II TAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0017015 regulation of transforming growth factor beta receptor signaling pathway IDA
 biological_processGO:0030514 negative regulation of BMP signaling pathway IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated NAS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070410 co-SMAD binding IPI
 molecular_functionGO:0070412 R-SMAD binding IPI


Pathways (from Reactome)
Pathway description
Downregulation of SMAD2/3:SMAD4 transcriptional activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000175387 SMAD2 / Q15796 / SMAD family member 2  / complex / reaction
 ENSG00000166949 SMAD3 / P84022 / SMAD family member 3  / complex / reaction
 ENSG00000141646 SMAD4 / Q13485 / SMAD family member 4  / complex / reaction






 

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