ENSG00000197958


Homo sapiens
ribosomalproteinlRPL12subunitdecayrrnatranslationmembranebindingc-terminaln-terminaldomainsuperfamilylargemrnaprocessingtranslationalsrp-dependentcotranslationaltargetingviralcytosolribosomeexpressionsnonsensemediatednmdexonjunction

Features
Gene ID: ENSG00000197958
  
Biological name :RPL12
  
Synonyms : P30050 / ribosomal protein L12 / RPL12
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: -1
Band: q33.3
Gene start: 127447674
Gene end: 127451405
  
Corresponding Affymetrix probe sets: 200088_x_at (Human Genome U133 Plus 2.0 Array)   200809_x_at (Human Genome U133 Plus 2.0 Array)   214271_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000441179
Ensembl peptide - ENSP00000354739
NCBI entrez gene - 6136     See in Manteia.
OMIM - 180475
RefSeq - NM_000976
RefSeq Peptide - NP_000967
swissprot - P30050
Ensembl - ENSG00000197958
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rpl12ENSDARG00000006691Danio rerio
 RPL12ENSGALG00000008806Gallus gallus
 Gm16519ENSMUSG00000066983Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000911  Ribosomal protein L11/L12
 IPR020783  Ribosomal protein L11, C-terminal
 IPR020784  Ribosomal protein L11, N-terminal
 IPR020785  Ribosomal protein L11, conserved site
 IPR036769  Ribosomal protein L11, C-terminal domain superfamily
 IPR036796  Ribosomal protein L11/L12, N-terminal domain superfamily


Gene Ontology (GO)
cellular component organizationcellular component biogenesisnitrogen compound metabolic processcatabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processbiosynthetic processmacromolecule localizationestablishment of localizationcellular localizationinterspecies interaction between organismscellular component organizationcellular component biogenesisnitrogen compound metabolic processcatabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processbiosynthetic processmacromolecule localizationestablishment of localizationcellular localizationinterspecies interaction between organismscellular component organizationcellular component biogenesisnitrogen compound metabolic processcatabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processbiosynthetic processmacromolecule localizationestablishment of localizationcellular localizationinterspecies interaction between organismscellular component organizationcellular component biogenesisnitrogen compound metabolic processcatabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processbiosynthetic processmacromolecule localizationestablishment of localizationcellular localizationinterspecies interaction between organismscellular component organizationcellular component biogenesisnitrogen compound metabolic processcatabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processbiosynthetic processmacromolecule localizationestablishment of localizationcellular localizationinterspecies interaction between organismscellular component organizationcellular component biogenesisnitrogen compound metabolic processcatabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processbiosynthetic processmacromolecule localizationestablishment of localizationcellular localizationinterspecies interaction between organismscellular component organizationcellular component biogenesisnitrogen compound metabolic processcatabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processbiosynthetic processmacromolecule localizationestablishment of localizationcellular localizationinterspecies interaction between organismscellular component organizationcellular component biogenesisnitrogen compound metabolic processcatabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processbiosynthetic processmacromolecule localizationestablishment of localizationcellular localizationinterspecies interaction between organismscellular component organizationcellular component biogenesisnitrogen compound metabolic processcatabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processbiosynthetic processmacromolecule localizationestablishment of localizationcellular localizationinterspecies interaction between organismscellular component organizationcellular component biogenesisnitrogen compound metabolic processcatabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processbiosynthetic processmacromolecule localizationestablishment of localizationcellular localizationinterspecies interaction between organismscellular cocellular component organizationcellular cocellular component biogenesisnitrogen conitrogen compound metabolic processcatabolic pcatabolic processcellular mecellular metabolic processprimary metprimary metabolic processorganic suborganic substance metabolic processbiosynthetibiosynthetic processmacromolecumacromolecule localizationestablishmeestablishment of localizationcellular locellular localizationinterspecieinterspecies interaction between organisms
organic cyclic compound bindingheterocyclic compound bindingstructural constituent of ribosomeprotein bindingorganic cyclic compound bindingheterocyclic compound bindingstructural constituent of ribosomeprotein bindingorganic cyclic compound bindingheterocyclic compound bindingstructural constituent of ribosomeprotein bindingorganic cyclic compound bindingheterocyclic compound bindingstructural constituent of ribosomeprotein bindingorganic cyclic compound bindingheterocyclic compound bindingstructural constituent of ribosomeprotein bindingorganic cyclic compound bindingheterocyclic compound bindingstructural constituent of ribosomeprotein bindingorganic cyclic compound bindingheterocyclic compound bindingstructural constituent of ribosomeprotein bindingorganic cyclic compound bindingheterocyclic compound bindingstructural constituent of ribosomeprotein bindingorganic cyclic compound bindingheterocyclic compound bindingstructural constituent of ribosomeprotein bindingorganic cyclic compound bindingheterocyclic compound bindingstructural constituent of ribosomeprotein bindingorganic cyclic compound bindingorganic cyclic compound bindingheterocyclic compound bindingheterocyclic compound bindingstructural constituent of ribosomestructural constituent of ribosomeprotein bindingprotein binding
cellprotein-containing complexorganellecell junctionmembraneextracellular regioncellprotein-containing complexorganellecell junctionmembraneextracellular regioncellprotein-containing complexorganellecell junctionmembraneextracellular regioncellprotein-containing complexorganellecell junctionmembraneextracellular regioncellprotein-containing complexorganellecell junctionmembraneextracellular regioncellprotein-containing complexorganellecell junctionmembraneextracellular regioncellprotein-containing complexorganellecell junctionmembraneextracellular regioncellprotein-containing complexorganellecell junctionmembraneextracellular regioncellprotein-containing complexorganellecell junctionmembraneextracellular regioncellprotein-containing complexorganellecell junctionmembraneextracellular regioncellcellprotein-containing compprotein-containing complexorganelleorganellecell junctioncell junctionmembranemembraneextracellular regionextracellular region
TypeGO IDTermEv.Code
 biological_processGO:0000027 ribosomal large subunit assembly IBA
 biological_processGO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
 biological_processGO:0006364 rRNA processing TAS
 biological_processGO:0006412 translation IBA
 biological_processGO:0006413 translational initiation TAS
 biological_processGO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS
 biological_processGO:0019083 viral transcription TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005840 ribosome IEA
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0022625 cytosolic large ribosomal subunit HDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003735 structural constituent of ribosome IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019843 rRNA binding IBA


Pathways (from Reactome)
Pathway description
L13a-mediated translational silencing of Ceruloplasmin expression
Peptide chain elongation
SRP-dependent cotranslational protein targeting to membrane
Viral mRNA Translation
Selenocysteine synthesis
Major pathway of rRNA processing in the nucleolus and cytosol
Formation of a pool of free 40S subunits
GTP hydrolysis and joining of the 60S ribosomal subunit
Eukaryotic Translation Termination
Regulation of expression of SLITs and ROBOs
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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