ENSG00000198825


Homo sapiens

Features
Gene ID: ENSG00000198825
  
Biological name :INPP5F
  
Synonyms : inositol polyphosphate-5-phosphatase F / INPP5F / Q9Y2H2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: 1
Band: q26.11
Gene start: 119726097
Gene end: 119829278
  
Corresponding Affymetrix probe sets: 203607_at (Human Genome U133 Plus 2.0 Array)   230362_at (Human Genome U133 Plus 2.0 Array)   230363_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000358076
Ensembl peptide - ENSP00000490226
Ensembl peptide - ENSP00000489864
Ensembl peptide - ENSP00000488905
Ensembl peptide - ENSP00000488726
Ensembl peptide - ENSP00000488052
Ensembl peptide - ENSP00000487706
Ensembl peptide - ENSP00000354519
NCBI entrez gene - 22876     See in Manteia.
OMIM - 609389
RefSeq - XM_011539524
RefSeq - XM_006717720
RefSeq - XM_011539528
RefSeq - XM_011539527
RefSeq - NM_001243194
RefSeq - NM_001243195
RefSeq - NM_014937
RefSeq - XM_017015936
RefSeq - XM_017015935
RefSeq - XM_011539525
RefSeq Peptide - NP_001230124
RefSeq Peptide - NP_001230123
RefSeq Peptide - NP_055752
swissprot - Q9Y2H2
swissprot - A0A1B0GUS5
swissprot - A0A0J9YVW6
swissprot - A0A0J9YWP2
swissprot - A0A0J9YY79
swissprot - A0A0J9YYL5
Ensembl - ENSG00000198825
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 A8E7C5ENSDARG00000061437Danio rerio
 INPP5FENSGALG00000009445Gallus gallus
 Inpp5fENSMUSG00000042105Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9NTJ5 / SACM1L / SAC1 like phosphatidylinositide phosphataseENSG0000021145617


Protein motifs (from Interpro)
Interpro ID Name
 IPR002013  SAC domain
 IPR019013  Vacuolar ATPase assembly integral membrane protein Vma21
 IPR022158  Inositol phosphatase
 IPR034753  hSac2 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001921 positive regulation of receptor recycling IDA
 biological_processGO:0006661 phosphatidylinositol biosynthetic process TAS
 biological_processGO:0008344 adult locomotory behavior IEA
 biological_processGO:0014898 cardiac muscle hypertrophy in response to stress ISS
 biological_processGO:0031161 phosphatidylinositol catabolic process ISS
 biological_processGO:0033137 negative regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0042532 negative regulation of tyrosine phosphorylation of STAT protein IDA
 biological_processGO:0046856 phosphatidylinositol dephosphorylation IDA
 biological_processGO:0048015 phosphatidylinositol-mediated signaling ISS
 biological_processGO:0048681 negative regulation of axon regeneration ISS
 biological_processGO:0051896 regulation of protein kinase B signaling IEA
 biological_processGO:0070072 vacuolar proton-transporting V-type ATPase complex assembly IEA
 biological_processGO:0072583 clathrin-dependent endocytosis ISS
 biological_processGO:2000145 regulation of cell motility IMP
 biological_processGO:2001135 regulation of endocytic recycling ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005905 clathrin-coated pit IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031901 early endosome membrane TAS
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0045334 clathrin-coated endocytic vesicle IDA
 cellular_componentGO:0055037 recycling endosome ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008934 inositol monophosphate 1-phosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0034595 phosphatidylinositol phosphate 5-phosphatase activity IDA
 molecular_functionGO:0034596 phosphatidylinositol phosphate 4-phosphatase activity IDA
 molecular_functionGO:0042578 phosphoric ester hydrolase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity ISS
 molecular_functionGO:0052832 inositol monophosphate 3-phosphatase activity IEA
 molecular_functionGO:0052833 inositol monophosphate 4-phosphatase activity IEA
 molecular_functionGO:0052834 inositol monophosphate phosphatase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of PIPs at the early endosome membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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