ENSG00000203697


Homo sapiens

Features
Gene ID: ENSG00000203697
  
Biological name :CAPN8
  
Synonyms : A6NHC0 / calpain 8 / CAPN8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q41
Gene start: 223538007
Gene end: 223665734
  
Corresponding Affymetrix probe sets: 229030_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000390294
Ensembl peptide - ENSP00000436371
Ensembl peptide - ENSP00000435953
Ensembl peptide - ENSP00000434013
Ensembl peptide - ENSP00000409233
Ensembl peptide - ENSP00000401665
Ensembl peptide - ENSP00000355837
Ensembl peptide - ENSP00000355838
NCBI entrez gene - 388743     See in Manteia.
RefSeq - NM_001143962
RefSeq - XM_017001265
RefSeq - XM_017001266
RefSeq - XM_017001267
RefSeq - XM_017001268
RefSeq Peptide - NP_001137434
swissprot - H0YEJ4
swissprot - B1B154
swissprot - H0YEQ4
swissprot - B1B153
swissprot - A6NHC0
swissprot - A3QK37
swissprot - A3QK36
swissprot - H0YDN4
Ensembl - ENSG00000203697
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 capn8ENSDARG00000055715Danio rerio
 CAPN8ENSGALG00000009382Gallus gallus
 Capn8ENSMUSG00000038599Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CAPN2 / P17655 / calpain 2ENSG0000016290962
CAPN1 / P07384 / calpain 1ENSG0000001421658
CAPN11 / Q9UMQ6 / calpain 11ENSG0000013722550
CAPN3 / P20807 / calpain 3ENSG0000009252949
CAPN9 / O14815 / calpain 9ENSG0000013577349
CAPN12 / Q6ZSI9 / calpain 12ENSG0000018247242
A8MX76 / CAPN14 / calpain 14ENSG0000021471137
CAPN5 / O15484 / calpain 5ENSG0000014926032
CAPN13 / Q6MZZ7 / calpain 13ENSG0000016294932
CAPN6 / Q9Y6Q1 / calpain 6ENSG0000007727429


Protein motifs (from Interpro)
Interpro ID Name
 IPR000169  Cysteine peptidase, cysteine active site
 IPR001300  Peptidase C2, calpain, catalytic domain
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site
 IPR022682  Peptidase C2, calpain, large subunit, domain III
 IPR022683  Peptidase C2, calpain, domain III
 IPR022684  Peptidase C2, calpain family
 IPR029543  Calpain-8
 IPR033883  Calpain subdomain III
 IPR036213  Calpain large subunit, domain III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IBA
 biological_processGO:0007586 digestion IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005794 Golgi apparatus IEA
 molecular_functionGO:0004198 calcium-dependent cysteine-type endopeptidase activity IBA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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