ENSG00000221818


Homo sapiens
transcriptionEBF2bindingfactorcoeregulationrnapolymeraseiidomaindna-templateddnaactivitydna-bindingcelldevelopmentchromatinproximalpromotersequence-specificiptimmunoglobulin-likefoldimmunoglobuline-setconservedsitehelix-loop-helixfatedeterminationmulticellular

Features
Gene ID: ENSG00000221818
  
Biological name :EBF2
  
Synonyms : early B cell factor 2 / EBF2 / Q9HAK2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: p21.2
Gene start: 25841730
Gene end: 26045397
  
Corresponding Affymetrix probe sets: 1562477_at (Human Genome U133 Plus 2.0 Array)   220392_at (Human Genome U133 Plus 2.0 Array)   244885_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000430241
Ensembl peptide - ENSP00000437909
Ensembl peptide - ENSP00000386178
NCBI entrez gene - 64641     See in Manteia.
OMIM - 609934
RefSeq - NM_022659
RefSeq Peptide - NP_073150
swissprot - B7Z934
swissprot - Q9HAK2
Ensembl - ENSG00000221818
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ebf2ENSDARG00000042525Danio rerio
 EBF2ENSGALG00000000242Gallus gallus
 Ebf2ENSMUSG00000022053Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EBF3 / Q9H4W6 / early B cell factor 3ENSG0000010800181
EBF1 / Q9UH73 / early B cell factor 1ENSG0000016433078
EBF4 / Q9BQW3 / early B cell factor 4ENSG0000008888170


Protein motifs (from Interpro)
Interpro ID Name
 IPR002909  IPT domain
 IPR003523  Transcription factor COE
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR018350  Transcription factor COE, conserved site
 IPR032200  Transcription factor COE, DNA-binding domain
 IPR032201  Transcription factor COE, helix-loop-helix domain


Gene Ontology (GO)
cellular developmental processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentregulation of molecular functioncellular developmental processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentregulation of molecular functioncellular developmental processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentregulation of molecular functioncellular developmental processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentregulation of molecular functioncellular developmental processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentregulation of molecular functioncellular developmental processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentregulation of molecular functioncellular developmental processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentregulation of molecular functioncellular developmental processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentregulation of molecular functioncellular developmental processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentregulation of molecular functioncellular developmental processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentregulation of molecular functioncellular developmcellular developmental processnitrogen compoundnitrogen compound metabolic processbiosynthetic procbiosynthetic processcellular metabolicellular metabolic processprimary metabolicprimary metabolic processorganic substanceorganic substance metabolic processanatomical structanatomical structure developmentregulation of molregulation of molecular function
organic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitychromatin bindingion bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitychromatin bindingion bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitychromatin bindingion bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitychromatin bindingion bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitychromatin bindingion bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitychromatin bindingion bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitychromatin bindingion bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitychromatin bindingion bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitychromatin bindingion bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitychromatin bindingion bindingprotein bindingorganic cyclic compoundorganic cyclic compound bindingheterocyclic compound bheterocyclic compound bindingDNA-binding transcriptiDNA-binding transcription factor activitychromatin bindingchromatin bindingion bindingion bindingprotein bindingprotein binding
cellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellcellorganelleorganelle
TypeGO IDTermEv.Code
 biological_processGO:0001709 cell fate determination IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0035563 positive regulation of chromatin binding IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0050873 brown fat cell differentiation IEA
 biological_processGO:0060612 adipose tissue development IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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