ENSG00000237693


Homo sapiens

Features
Gene ID: ENSG00000237693
  
Biological name :IRGM
  
Synonyms : A1A4Y4 / immunity related GTPase M / IRGM
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q33.1
Gene start: 150846523
Gene end: 150900736
  
Corresponding Affymetrix probe sets: 1563335_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000428220
Ensembl peptide - ENSP00000429819
NCBI entrez gene - 345611     See in Manteia.
OMIM - 608212
RefSeq - NM_001145805
RefSeq Peptide - NP_001139277
swissprot - A1A4Y4
swissprot - H0YBM2
Ensembl - ENSG00000237693
  
Related genetic diseases (OMIM): 607948 - {Mycobacterium tuberculosis, protection against}, 607948
  612278 - {Inflammatory bowel disease (Crohn disease) 19}, 612278
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 irgq2ENSDARG00000068657Danio rerio
 IgtpENSMUSG00000078853Mus musculus
 Irgm1ENSMUSG00000046879Mus musculus
 Irgm2ENSMUSG00000069874Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IRGC / Q6NXR0 / immunity related GTPase cinemaENSG0000012444932


Protein motifs (from Interpro)
Interpro ID Name
 IPR007743  Immunity-related GTPases-like
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR030385  IRG-type guanine nucleotide-binding (G) domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000045 autophagosome assembly IMP
 biological_processGO:0001934 positive regulation of protein phosphorylation IMP
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0010508 positive regulation of autophagy IMP
 biological_processGO:0010800 positive regulation of peptidyl-threonine phosphorylation IMP
 biological_processGO:0031648 protein destabilization IMP
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IMP
 biological_processGO:0042742 defense response to bacterium IMP
 biological_processGO:0043254 regulation of protein complex assembly IMP
 biological_processGO:0045087 innate immune response IMP
 biological_processGO:0050821 protein stabilization IMP
 biological_processGO:0050829 defense response to Gram-negative bacterium IMP
 biological_processGO:0060335 positive regulation of interferon-gamma-mediated signaling pathway IMP
 biological_processGO:0061635 regulation of protein complex stability IMP
 biological_processGO:0061739 protein lipidation involved in autophagosome assembly IMP
 biological_processGO:0061762 CAMKK-AMPK signaling cascade IMP
 biological_processGO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway IMP
 biological_processGO:0071222 cellular response to lipopolysaccharide IMP
 biological_processGO:0071902 positive regulation of protein serine/threonine kinase activity IMP
 biological_processGO:0075044 autophagy of host cells involved in interaction with symbiont IMP
 biological_processGO:0098586 cellular response to virus IMP
 biological_processGO:1901098 positive regulation of autophagosome maturation IMP
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0000421 autophagosome membrane IEA
 cellular_componentGO:0001891 phagocytic cup IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030670 phagocytic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0043539 protein serine/threonine kinase activator activity IMP
 molecular_functionGO:0050700 CARD domain binding IMP
 molecular_functionGO:0051434 BH3 domain binding IMP


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr