Manteia

ENSG00000241244

Homo sapiens

Features

Gene ID:	ENSG00000241244

Biological name :	IGKV1D-16

Synonyms :	IGKV1D-16 / immunoglobulin kappa variable 1D-16 / P01601

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	2
Strand:	1
Band:	p11.2
Gene start:	90100236
Gene end:	90100738

Corresponding Affymetrix probe sets:

Cross references:	Ensembl peptide - ENSP00000418200 swissprot - P01601 Ensembl - ENSG00000241244

See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
IGKV1D-12	ENSDARG00000040601	Danio rerio
Igkv12-44	ENSMUSG00000096422	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
P04430 / IGKV1-16 / immunoglobulin kappa variable 1-16	ENSG00000240864	96
IGKV1-12 / A0A0C4DH73 / immunoglobulin kappa variable 1-12	ENSG00000243290	93
P01611 / IGKV1D-12 / immunoglobulin kappa variable 1D-12	ENSG00000278857	92
IGKV1-9 / A0A0C4DH69 / immunoglobulin kappa variable 1-9	ENSG00000241755	91
P0DP09 / IGKV1D-13 / A0A0B4J2D9 / immunoglobulin kappa variable 1D-13	ENSG00000276566	91
P01597 / IGKV1-39 / immunoglobulin kappa variable 1-39 (gene/pseudogene)	ENSG00000242371	90
P04432 / IGKV1D-39 / immunoglobulin kappa variable 1D-39	ENSG00000251546	90
P01602 / IGKV1-5 / immunoglobulin kappa variable 1-5	ENSG00000243466	89
IGKV1-6 / A0A0C4DH72 / immunoglobulin kappa variable 1-6	ENSG00000239855	88
IGKV1-27 / A0A075B6S5 / immunoglobulin kappa variable 1-27	ENSG00000244575	88
IGKV1D-43 / A0A0B4J1Z2 / immunoglobulin kappa variable 1D-43	ENSG00000242580	87
IGKV1-8 / A0A0C4DH67 / immunoglobulin kappa variable 1-8	ENSG00000240671	86
IGKV1D-8 / A0A087WSZ0 / immunoglobulin kappa variable 1D-8	ENSG00000239819	85
IGKV1OR2-108 / immunoglobulin kappa variable 1/OR2-108 (non-functional)	ENSG00000231292	84
IGKV1-37 / immunoglobulin kappa variable 1-37 (non-functional)	ENSG00000239862	83
IGKV1D-37 / immunoglobulin kappa variable 1D-37 (non-functional)	ENSG00000250036	83
P01593 / IGKV1D-33 / immunoglobulin kappa variable 1D-33	ENSG00000239975	68
P01594 / IGKV1-33 / immunoglobulin kappa variable 1-33	ENSG00000242076	68
P01619 / IGKV3-20 / immunoglobulin kappa variable 3-20	ENSG00000239951	65
P01624 / IGKV3-15 / immunoglobulin kappa variable 3-15	ENSG00000244437	65

Protein motifs (from Interpro)

Interpro ID

Name

No match

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0002250	adaptive immune response	IEA
biological_process	GO:0002376	immune system process	IEA
biological_process	GO:0002377	immunoglobulin production	IBA
biological_process	GO:0006508	proteolysis	IEA
biological_process	GO:0006898	receptor-mediated endocytosis	TAS
biological_process	GO:0006955	immune response	IBA
biological_process	GO:0006956	complement activation	TAS
biological_process	GO:0006958	complement activation, classical pathway	TAS
biological_process	GO:0030449	regulation of complement activation	TAS
biological_process	GO:0038095	Fc-epsilon receptor signaling pathway	TAS
biological_process	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	TAS
biological_process	GO:0050776	regulation of immune response	TAS
biological_process	GO:0050900	leukocyte migration	TAS
cellular_component	GO:0005576	extracellular region	TAS
cellular_component	GO:0005615	extracellular space	IBA
cellular_component	GO:0005886	plasma membrane	TAS
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0070062	extracellular exosome	HDA
molecular_function	GO:0003823	antigen binding	NAS
molecular_function	GO:0004252	serine-type endopeptidase activity	TAS

Pathways (from Reactome)

Pathway description

Initial triggering of complement

Classical antibody-mediated complement activation

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Cell surface interactions at the vascular wall

FCGR activation

Regulation of actin dynamics for phagocytic cup formation

Role of phospholipids in phagocytosis

Scavenging of heme from plasma

Fc epsilon receptor (FCERI) signaling

Role of LAT2/NTAL/LAB on calcium mobilization

FCERI mediated MAPK activation

FCERI mediated Ca+2 mobilization

FCERI mediated NF-kB activation

CD22 mediated BCR regulation

Regulation of Complement cascade

Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

External programs and data are copyrighted by and are the property of their respective authors. The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation
		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr