ENSG00000241351


Homo sapiens

Features
Gene ID: ENSG00000241351
  
Biological name :IGKV3-11
  
Synonyms : IGKV3-11 / immunoglobulin kappa variable 3-11 / P04433
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: p11.2
Gene start: 89027171
Gene end: 89027731
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSP00000420118
swissprot - P04433
Ensembl - ENSG00000241351
  
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IGKV1D-12ENSDARG00000040601Danio rerio
 Igkv18-36ENSMUSG00000076572Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IGKV3D-11 / A0A0A0MRZ8 / immunoglobulin kappa variable 3D-11ENSG0000021163298
IGKV3D-20 / A0A0C4DH25 / immunoglobulin kappa variable 3D-20ENSG0000021162591
P01619 / IGKV3-20 / immunoglobulin kappa variable 3-20ENSG0000023995191
P01624 / IGKV3-15 / immunoglobulin kappa variable 3-15ENSG0000024443791
IGKV3D-15 / A0A087WSY6 / immunoglobulin kappa variable 3D-15 (gene/pseudogene)ENSG0000022404190
IGKV3-7 / immunoglobulin kappa variable 3-7 (non-functional)ENSG0000024306390
IGKV1-9 / A0A0C4DH69 / immunoglobulin kappa variable 1-9ENSG0000024175570
P0DP09 / IGKV1D-13 / A0A0B4J2D9 / immunoglobulin kappa variable 1D-13ENSG0000027656670
P01597 / IGKV1-39 / immunoglobulin kappa variable 1-39 (gene/pseudogene)ENSG0000024237169
P04432 / IGKV1D-39 / immunoglobulin kappa variable 1D-39ENSG0000025154669
IGKV1D-8 / A0A087WSZ0 / immunoglobulin kappa variable 1D-8ENSG0000023981968
P01602 / IGKV1-5 / immunoglobulin kappa variable 1-5ENSG0000024346668
IGKV1-27 / A0A075B6S5 / immunoglobulin kappa variable 1-27ENSG0000024457568
IGKV1-8 / A0A0C4DH67 / immunoglobulin kappa variable 1-8ENSG0000024067167
IGKV1-12 / A0A0C4DH73 / immunoglobulin kappa variable 1-12ENSG0000024329067
P01611 / IGKV1D-12 / immunoglobulin kappa variable 1D-12ENSG0000027885767
P06312 / IGKV4-1 / immunoglobulin kappa variable 4-1ENSG0000021159866
IGKV1-6 / A0A0C4DH72 / immunoglobulin kappa variable 1-6ENSG0000023985566
IGKV1OR2-108 / immunoglobulin kappa variable 1/OR2-108 (non-functional)ENSG0000023129265
IGKV1-37 / immunoglobulin kappa variable 1-37 (non-functional)ENSG0000023986265


Protein motifs (from Interpro)
Interpro ID Name
No match


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006898 receptor-mediated endocytosis TAS
 biological_processGO:0006955 immune response NAS
 biological_processGO:0006956 complement activation TAS
 biological_processGO:0006958 complement activation, classical pathway TAS
 biological_processGO:0030449 regulation of complement activation TAS
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway TAS
 biological_processGO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
 biological_processGO:0050776 regulation of immune response TAS
 biological_processGO:0050900 leukocyte migration TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0072562 blood microparticle HDA
 molecular_functionGO:0003823 antigen binding NAS
 molecular_functionGO:0004252 serine-type endopeptidase activity TAS


Pathways (from Reactome)
Pathway description
Initial triggering of complement
Classical antibody-mediated complement activation
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Cell surface interactions at the vascular wall
FCGR activation
Regulation of actin dynamics for phagocytic cup formation
Role of phospholipids in phagocytosis
Scavenging of heme from plasma
Fc epsilon receptor (FCERI) signaling
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated NF-kB activation
CD22 mediated BCR regulation
Regulation of Complement cascade
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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