Manteia

ENSG00000249915

Homo sapiens

Features

Gene ID:	ENSG00000249915

Biological name :	PDCD6

Synonyms :	O75340 / PDCD6 / programmed cell death 6

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	5
Strand:	1
Band:	p15.33
Gene start:	271621
Gene end:	353856

Corresponding Affymetrix probe sets:	1568763_s_at (Human Genome U133 Plus 2.0 Array) 203415_at (Human Genome U133 Plus 2.0 Array) 222152_at (Human Genome U133 Plus 2.0 Array) 222380_s_at (Human Genome U133 Plus 2.0 Array)

Cross references:	Ensembl peptide - ENSP00000424201 Ensembl peptide - ENSP00000485941 Ensembl peptide - ENSP00000485024 Ensembl peptide - ENSP00000482332 Ensembl peptide - ENSP00000426003 Ensembl peptide - ENSP00000425370 Ensembl peptide - ENSP00000264933 Ensembl peptide - ENSP00000422085 Ensembl peptide - ENSP00000422691 Ensembl peptide - ENSP00000423815 NCBI entrez gene - 10016 See in Manteia. OMIM - 601057 RefSeq - NM_013232 RefSeq - NM_001267556 RefSeq - NM_001267557 RefSeq - NM_001267558 RefSeq - NM_001267559 RefSeq Peptide - NP_001254485 RefSeq Peptide - NP_001254487 RefSeq Peptide - NP_001254488 RefSeq Peptide - NP_037364 RefSeq Peptide - NP_001254486 swissprot - Q86W51 swissprot - D6RA21 swissprot - A0A087WZ38 swissprot - A0A024QZ42 swissprot - H0Y9X3 swissprot - O75340 swissprot - E7EPW6 Ensembl - ENSG00000249915

See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
pdcd6	ENSDARG00000005220	Danio rerio
PDCD6	ENSGALG00000013400	Gallus gallus
Pdcd6	ENSMUSG00000021576	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
PEF1 / Q9UBV8 / penta-EF-hand domain containing 1	ENSG00000162517	43
SRI / P30626 / sorcin	ENSG00000075142	34
GCA / P28676 / grancalcin	ENSG00000115271	31
CAPNS2 / Q96L46 / calpain small subunit 2	ENSG00000256812	26
CAPNS1 / P04632 / calpain small subunit 1	ENSG00000126247	25

Protein motifs (from Interpro)

Interpro ID	Name
IPR002048	EF-hand domain
IPR011992	EF-hand domain pair
IPR018247	EF-Hand 1, calcium-binding site

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001525	angiogenesis	IEA
biological_process	GO:0001938	positive regulation of endothelial cell proliferation	IDA
biological_process	GO:0006508	proteolysis	IEA
biological_process	GO:0006886	intracellular protein transport	IDA
biological_process	GO:0006888	ER to Golgi vesicle-mediated transport	IMP
biological_process	GO:0006915	apoptotic process	IEA
biological_process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	IEA
biological_process	GO:0010595	positive regulation of endothelial cell migration	IDA
biological_process	GO:0014029	neural crest formation	IMP
biological_process	GO:0014032	neural crest cell development	IMP
biological_process	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway	IDA
biological_process	GO:0032007	negative regulation of TOR signaling	IDA
biological_process	GO:0034605	cellular response to heat	IDA
biological_process	GO:0036324	vascular endothelial growth factor receptor-2 signaling pathway	IDA
biological_process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA
biological_process	GO:0045766	positive regulation of angiogenesis	IDA
biological_process	GO:0048208	COPII vesicle coating	IMP
biological_process	GO:0051592	response to calcium ion	ISS
biological_process	GO:0051898	negative regulation of protein kinase B signaling	IDA
biological_process	GO:0097190	apoptotic signaling pathway	TAS
biological_process	GO:1902527	positive regulation of protein monoubiquitination	IMP
cellular_component	GO:0000139	Golgi membrane	IEA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005768	endosome	IEA
cellular_component	GO:0005783	endoplasmic reticulum	IEA
cellular_component	GO:0005789	endoplasmic reticulum membrane	IEA
cellular_component	GO:0012507	ER to Golgi transport vesicle membrane	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0030127	COPII vesicle coat	IDA
cellular_component	GO:0031410	cytoplasmic vesicle	IEA
cellular_component	GO:0031463	Cul3-RING ubiquitin ligase complex	IDA
cellular_component	GO:0070062	extracellular exosome	HDA
cellular_component	GO:0070971	endoplasmic reticulum exit site	IMP
molecular_function	GO:0000287	magnesium ion binding	ISS
molecular_function	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	IBA
molecular_function	GO:0005509	calcium ion binding	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0042802	identical protein binding	IPI
molecular_function	GO:0042803	protein homodimerization activity	IDA
molecular_function	GO:0043495	protein membrane anchor	IMP
molecular_function	GO:0046872	metal ion binding	IEA
molecular_function	GO:0046983	protein dimerization activity	IPI
molecular_function	GO:0048306	calcium-dependent protein binding	IPI
molecular_function	GO:0060090	molecular adaptor activity	IMP

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr