ENSG00000270276


Homo sapiens

Features
Gene ID: ENSG00000270276
  
Biological name :HIST2H4B
  
Synonyms : HIST2H4B / histone cluster 2 H4 family member b / P62805
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q21.2
Gene start: 149854045
Gene end: 149861210
  
Corresponding Affymetrix probe sets: 207046_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000481507
Ensembl peptide - ENSP00000482412
Ensembl peptide - ENSP00000462355
NCBI entrez gene - 554313     See in Manteia.
RefSeq - NM_001034077
RefSeq Peptide - NP_001029249
swissprot - B2R4R0
swissprot - P62805
Ensembl - ENSG00000270276
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zgc:165555ENSDARG00000061547Danio rerio
 P62801ENSGALG00000025786Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P62805 / HIST1H4H / histone cluster 1 H4 family member hENSG00000158406100
P62805 / HIST1H4C / histone cluster 1 H4 family member cENSG00000197061100
P62805 / HIST1H4J / histone cluster 1 H4 family member jENSG00000197238100
P62805 / HIST4H4 / histone cluster 4 H4ENSG00000197837100
P62805 / HIST2H4A / histone cluster 2 H4 family member aENSG00000270882100
P62805 / HIST1H4K / histone cluster 1 H4 family member kENSG00000273542100
P62805 / HIST1H4F / histone cluster 1 H4 family member fENSG00000274618100
P62805 / HIST1H4L / histone cluster 1 H4 family member lENSG00000275126100
P62805 / HIST1H4I / histone cluster 1 H4 family member iENSG00000276180100
P62805 / HIST1H4E / histone cluster 1 H4 family member eENSG00000276966100
P62805 / HIST1H4D / histone cluster 1 H4 family member dENSG00000277157100
P62805 / HIST1H4A / histone cluster 1 H4 family member aENSG00000278637100
P62805 / HIST1H4B / histone cluster 1 H4 family member bENSG00000278705100
Q99525 / HIST1H4G / histone cluster 1 H4 family member gENSG0000027566380


Protein motifs (from Interpro)
Interpro ID Name
 IPR001951  Histone H4
 IPR004823  TATA box binding protein associated factor (TAF)
 IPR009072  Histone-fold
 IPR019809  Histone H4, conserved site
 IPR035425  CENP-T/Histone H4, histone fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000183 chromatin silencing at rDNA TAS
 biological_processGO:0006303 double-strand break repair via nonhomologous end joining TAS
 biological_processGO:0006334 nucleosome assembly IBA
 biological_processGO:0006335 DNA replication-dependent nucleosome assembly IDA
 biological_processGO:0006336 DNA replication-independent nucleosome assembly IDA
 biological_processGO:0006352 DNA-templated transcription, initiation IEA
 biological_processGO:0016233 telomere capping TAS
 biological_processGO:0032200 telomere organization TAS
 biological_processGO:0034080 CENP-A containing nucleosome assembly TAS
 biological_processGO:0044267 cellular protein metabolic process TAS
 biological_processGO:0045652 regulation of megakaryocyte differentiation TAS
 biological_processGO:0045653 negative regulation of megakaryocyte differentiation IDA
 biological_processGO:0045814 negative regulation of gene expression, epigenetic TAS
 biological_processGO:0045815 positive regulation of gene expression, epigenetic TAS
 biological_processGO:0051290 protein heterotetramerization IDA
 biological_processGO:0060964 regulation of gene silencing by miRNA TAS
 biological_processGO:1902036 regulation of hematopoietic stem cell differentiation TAS
 biological_processGO:1904837 beta-catenin-TCF complex assembly TAS
 cellular_componentGO:0000228 nuclear chromosome IDA
 cellular_componentGO:0000784 nuclear chromosome, telomeric region HDA
 cellular_componentGO:0000786 nucleosome TAS
 cellular_componentGO:0000788 nuclear nucleosome IBA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003677 DNA binding IBA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0042393 histone binding IBA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Meiotic synapsis
Packaging Of Telomere Ends
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
HDACs deacetylate histones
PKMTs methylate histone lysines
HDMs demethylate histones
HATs acetylate histones
RMTs methylate histone arginines
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
SUMOylation of chromatin organization proteins
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
Deposition of new CENPA-containing nucleosomes at the centromere
G2/M DNA damage checkpoint
RNA Polymerase I Promoter Opening
RNA Polymerase I Chain Elongation
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination
Amyloid fiber formation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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