ENSG00000273749


Homo sapiens

Features
Gene ID: ENSG00000273749
  
Biological name :CYFIP1
  
Synonyms : CYFIP1 / cytoplasmic FMR1 interacting protein 1 / Q7L576
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: -1
Band: q11.2
Gene start: 22867052
Gene end: 22981063
  
Corresponding Affymetrix probe sets: 208923_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000479802
Ensembl peptide - ENSP00000478779
Ensembl peptide - ENSP00000480307
Ensembl peptide - ENSP00000482459
Ensembl peptide - ENSP00000481038
Ensembl peptide - ENSP00000480596
Ensembl peptide - ENSP00000480525
Ensembl peptide - ENSP00000453060
Ensembl peptide - ENSP00000478377
NCBI entrez gene - 23191     See in Manteia.
OMIM - 606322
RefSeq - NM_014608
RefSeq - NM_001033028
RefSeq - NM_001287810
RefSeq - NM_001324119
RefSeq - NM_001324120
RefSeq - NM_001324122
RefSeq - NM_001324123
RefSeq - NM_001324124
RefSeq - NM_001324125
RefSeq - NM_001324126
RefSeq - XM_011543873
RefSeq - XM_011543874
RefSeq - XM_011543876
RefSeq - XM_017022023
RefSeq - XM_017022024
RefSeq Peptide - NP_001311051
RefSeq Peptide - NP_001311052
RefSeq Peptide - NP_001311053
RefSeq Peptide - NP_001311054
RefSeq Peptide - NP_001311055
RefSeq Peptide - NP_055423
RefSeq Peptide - NP_001274739
RefSeq Peptide - NP_001028200
RefSeq Peptide - NP_001311048
RefSeq Peptide - NP_001311049
swissprot - Q7L576
swissprot - A0A087WZ89
swissprot - A0A087WWY5
swissprot - A0A087WWL1
swissprot - A0A087WVZ5
swissprot - H0YL50
swissprot - A0A087WU52
Ensembl - ENSG00000273749
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cyfip1ENSDARG00000044345Danio rerio
 CYFIP1ENSGALG00000016736Gallus gallus
 Cyfip1ENSMUSG00000030447Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CYFIP2 / Q96F07 / cytoplasmic FMR1 interacting protein 2ENSG0000005516387


Protein motifs (from Interpro)
Interpro ID Name
 IPR008081  Cytoplasmic FMR1-interacting
 IPR009828  Protein of unknown function DUF1394


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0008360 regulation of cell shape IEA
 biological_processGO:0016601 Rac protein signal transduction IMP
 biological_processGO:0030032 lamellipodium assembly ISS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0031529 ruffle organization ISS
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0045773 positive regulation of axon extension IEA
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway TAS
 biological_processGO:0048675 axon extension IMP
 biological_processGO:0050772 positive regulation of axonogenesis IEA
 biological_processGO:0050890 cognition IMP
 biological_processGO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway IEA
 biological_processGO:0051602 response to electrical stimulus IEA
 biological_processGO:0097484 dendrite extension IEA
 biological_processGO:0099563 modification of synaptic structure IEA
 biological_processGO:1900006 positive regulation of dendrite development IEA
 biological_processGO:1900029 positive regulation of ruffle assembly IEA
 biological_processGO:1903422 negative regulation of synaptic vesicle recycling IEA
 biological_processGO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation IMP
 cellular_componentGO:0001726 ruffle ISS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005845 mRNA cap binding complex ISS
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0030027 lamellipodium ISS
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031209 SCAR complex IMP
 cellular_componentGO:0032433 filopodium tip IEA
 cellular_componentGO:0034774 secretory granule lumen TAS
 cellular_componentGO:0035580 specific granule lumen TAS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection ISS
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043195 terminal bouton IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0044294 dendritic growth cone IEA
 cellular_componentGO:0044295 axonal growth cone IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISS
 cellular_componentGO:0060076 excitatory synapse IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0090724 central region of growth cone IEA
 cellular_componentGO:0090725 peripheral region of growth cone IEA
 cellular_componentGO:1904724 tertiary granule lumen TAS
 molecular_functionGO:0000340 RNA 7-methylguanosine cap binding IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0044877 protein-containing complex binding IMP
 molecular_functionGO:0048365 Rac GTPase binding ISS
 molecular_functionGO:0051015 actin filament binding ISS


Pathways (from Reactome)
Pathway description
Regulation of actin dynamics for phagocytic cup formation
VEGFA-VEGFR2 Pathway
RHO GTPases Activate WASPs and WAVEs
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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