ENSG00000284190


Homo sapiens

Features
Gene ID: ENSG00000284190
  
Biological name :MIR21
  
Synonyms : microRNA 21 / MIR21
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q23.1
Gene start: 59841266
Gene end: 59841337
  
Corresponding Affymetrix probe sets: 224917_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl - ENSG00000284190
  
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
No match


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
No match


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation ISS
 biological_processGO:0001937 negative regulation of endothelial cell proliferation IDA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway ISS
 biological_processGO:0007566 embryo implantation NAS
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0008360 regulation of cell shape IMP
 biological_processGO:0010595 positive regulation of endothelial cell migration IDA
 biological_processGO:0010596 negative regulation of endothelial cell migration IDA
 biological_processGO:0010613 positive regulation of cardiac muscle hypertrophy ISS
 biological_processGO:0010614 negative regulation of cardiac muscle hypertrophy ISS
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0010667 negative regulation of cardiac muscle cell apoptotic process ISS
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition IDA
 biological_processGO:0010838 positive regulation of keratinocyte proliferation IDA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IMP
 biological_processGO:0016525 negative regulation of angiogenesis ISS
 biological_processGO:0030334 regulation of cell migration IGI
 biological_processGO:0030335 positive regulation of cell migration IMP
 biological_processGO:0030336 negative regulation of cell migration IDA
 biological_processGO:0030509 BMP signaling pathway IMP
 biological_processGO:0031346 positive regulation of cell projection organization ISS
 biological_processGO:0032148 activation of protein kinase B activity IMP
 biological_processGO:0032480 negative regulation of type I interferon production IDA
 biological_processGO:0032963 collagen metabolic process ISS
 biological_processGO:0034260 negative regulation of GTPase activity IDA
 biological_processGO:0034392 negative regulation of smooth muscle cell apoptotic process ISS
 biological_processGO:0035195 gene silencing by miRNA IMP
 biological_processGO:0035278 miRNA mediated inhibition of translation IMP
 biological_processGO:0036166 phenotypic switching IDA
 biological_processGO:0042058 regulation of epidermal growth factor receptor signaling pathway IMP
 biological_processGO:0042104 positive regulation of activated T cell proliferation IGI
 biological_processGO:0043065 positive regulation of apoptotic process IDA
 biological_processGO:0043066 negative regulation of apoptotic process IDA
 biological_processGO:0045590 negative regulation of regulatory T cell differentiation IGI
 biological_processGO:0045600 positive regulation of fat cell differentiation IDA
 biological_processGO:0045603 positive regulation of endothelial cell differentiation IDA
 biological_processGO:0045669 positive regulation of osteoblast differentiation IDA
 biological_processGO:0045766 positive regulation of angiogenesis IDA
 biological_processGO:0045824 negative regulation of innate immune response IMP
 biological_processGO:0050729 positive regulation of inflammatory response IMP
 biological_processGO:0051497 negative regulation of stress fiber assembly IDA
 biological_processGO:0051896 regulation of protein kinase B signaling ISS
 biological_processGO:0051897 positive regulation of protein kinase B signaling IMP
 biological_processGO:0060339 negative regulation of type I interferon-mediated signaling pathway IDA
 biological_processGO:0060940 epithelial to mesenchymal transition involved in cardiac fibroblast development IDA
 biological_processGO:0061037 negative regulation of cartilage development IDA
 biological_processGO:0061154 endothelial tube morphogenesis IMP
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IDA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade ISS
 biological_processGO:0071222 cellular response to lipopolysaccharide IMP
 biological_processGO:0106016 positive regulation of inflammatory response to wounding ISS
 biological_processGO:1900017 positive regulation of cytokine production involved in inflammatory response ISS
 biological_processGO:1900039 positive regulation of cellular response to hypoxia ISS
 biological_processGO:1900082 negative regulation of arginine catabolic process ISS
 biological_processGO:1901223 negative regulation of NIK/NF-kappaB signaling IMP
 biological_processGO:1901299 negative regulation of hydrogen peroxide-mediated programmed cell death ISS
 biological_processGO:1901670 negative regulation of superoxide dismutase activity IDA
 biological_processGO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator IDA
 biological_processGO:1902304 positive regulation of potassium ion export IDA
 biological_processGO:1902504 regulation of signal transduction involved in mitotic G2 DNA damage checkpoint IMP
 biological_processGO:1902514 regulation of calcium ion transmembrane transport via high voltage-gated calcium channel IDA
 biological_processGO:1902731 negative regulation of chondrocyte proliferation IDA
 biological_processGO:1903427 negative regulation of reactive oxygen species biosynthetic process ISS
 biological_processGO:1904639 cellular response to resveratrol ISS
 biological_processGO:1904685 positive regulation of metalloendopeptidase activity IDA
 biological_processGO:1904695 positive regulation of vascular smooth muscle contraction IDA
 biological_processGO:1904707 positive regulation of vascular smooth muscle cell proliferation ISS
 biological_processGO:1904728 positive regulation of replicative senescence IDA
 biological_processGO:1904753 negative regulation of vascular associated smooth muscle cell migration IDA
 biological_processGO:1904754 positive regulation of vascular associated smooth muscle cell migration ISS
 biological_processGO:1904762 positive regulation of myofibroblast differentiation IMP
 biological_processGO:1904827 negative regulation of hydrogen sulfide biosynthetic process IDA
 biological_processGO:1904830 negative regulation of aortic smooth muscle cell differentiation IDA
 biological_processGO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell IMP
 biological_processGO:1905065 positive regulation of vascular smooth muscle cell differentiation IMP
 biological_processGO:1905460 negative regulation of vascular associated smooth muscle cell apoptotic process IDA
 biological_processGO:1905564 positive regulation of vascular endothelial cell proliferation IDA
 biological_processGO:1905955 negative regulation of endothelial tube morphogenesis ISS
 biological_processGO:2000134 negative regulation of G1/S transition of mitotic cell cycle IMP
 biological_processGO:2000318 positive regulation of T-helper 17 type immune response ISS
 biological_processGO:2000321 positive regulation of T-helper 17 cell differentiation ISS
 biological_processGO:2000377 regulation of reactive oxygen species metabolic process ISS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0070062 extracellular exosome IDA
 molecular_functionGO:0003730 mRNA 3"-UTR binding IDA
 molecular_functionGO:1903231 mRNA binding involved in posttranscriptional gene silencing IMP


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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