ENSGALG00000000209


Gallus gallus

Features
Gene ID: ENSGALG00000000209
  
Biological name :PRNP
  
Synonyms : Major prion protein homolog / P27177 / PRNP
  
Possible biological names infered from orthology : P04156 / P04925 / prion protein
  
Species: Gallus gallus
  
Chr. number: 22
Strand: -1
Band:
Gene start: 439955
Gene end: 444495
  
Corresponding Affymetrix probe sets: Gga.3867.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000059144
Ensembl peptide - ENSGALP00000040285
NCBI entrez gene - 396452     See in Manteia.
RefSeq - XM_015297300
RefSeq - NM_205465
RefSeq Peptide - NP_990796
swissprot - P27177
swissprot - A0A1L1RK71
Ensembl - ENSGALG00000000209
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PRNPENSG00000171867Homo sapiens
 PrnpENSMUSG00000079037Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000817  Prion protein
 IPR022416  Prion/Doppel protein, beta-ribbon domain
 IPR025860  Major prion protein N-terminal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001933 negative regulation of protein phosphorylation IEA
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0007611 learning or memory IEA
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0010870 positive regulation of receptor biosynthetic process IDA
 biological_processGO:0010942 positive regulation of cell death IEA
 biological_processGO:0031648 protein destabilization IEA
 biological_processGO:0032147 activation of protein kinase activity IEA
 biological_processGO:0032689 negative regulation of interferon-gamma production IEA
 biological_processGO:0032700 negative regulation of interleukin-17 production IEA
 biological_processGO:0032703 negative regulation of interleukin-2 production IEA
 biological_processGO:0032880 regulation of protein localization IEA
 biological_processGO:0035584 calcium-mediated signaling using intracellular calcium source IEA
 biological_processGO:0035690 cellular response to drug IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0043525 positive regulation of neuron apoptotic process IEA
 biological_processGO:0046007 negative regulation of activated T cell proliferation IEA
 biological_processGO:0050730 regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0050860 negative regulation of T cell receptor signaling pathway IEA
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0061098 positive regulation of protein tyrosine kinase activity IEA
 biological_processGO:0070885 negative regulation of calcineurin-NFAT signaling cascade IEA
 biological_processGO:0071280 cellular response to copper ion IEA
 biological_processGO:0090314 positive regulation of protein targeting to membrane IEA
 biological_processGO:0090647 modulation of age-related behavioral decline IEA
 biological_processGO:0098737 protein insertion into plasma membrane IDA
 biological_processGO:1901216 positive regulation of neuron death IEA
 biological_processGO:1901379 regulation of potassium ion transmembrane transport IEA
 biological_processGO:1902430 negative regulation of amyloid-beta formation IEA
 biological_processGO:1902938 regulation of intracellular calcium activated chloride channel activity IEA
 biological_processGO:1902951 negative regulation of dendritic spine maintenance IEA
 biological_processGO:1902992 negative regulation of amyloid precursor protein catabolic process IEA
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane IEA
 biological_processGO:1904645 response to amyloid-beta IEA
 biological_processGO:1904646 cellular response to amyloid-beta IEA
 biological_processGO:1905664 regulation of calcium ion import across plasma membrane IEA
 biological_processGO:1990535 neuron projection maintenance IEA
 cellular_componentGO:0005605 basal lamina IDA
 cellular_componentGO:0005623 cell IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016234 inclusion body IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031225 anchored component of membrane IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 cellular_componentGO:0043083 synaptic cleft IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0106003 amyloid-beta complex IEA
 molecular_functionGO:0001540 amyloid-beta binding IEA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005507 copper ion binding IEA
 molecular_functionGO:0005515 protein binding IMP
 molecular_functionGO:0005539 glycosaminoglycan binding IEA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0015631 tubulin binding IEA
 molecular_functionGO:0031802 type 5 metabotropic glutamate receptor binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0044877 protein-containing complex binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:1903135 cupric ion binding IEA
 molecular_functionGO:1903136 cuprous ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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