ENSGALG00000000349


Gallus gallus

Features
Gene ID: ENSGALG00000000349
  
Biological name :PSMC5
  
Synonyms : proteasome 26S subunit, ATPase 5 / PSMC5
  
Possible biological names infered from orthology : P62195 / P62196 / protease (prosome, macropain) 26S subunit, ATPase 5
  
Species: Gallus gallus
  
Chr. number: 27
Strand: 1
Band:
Gene start: 1872536
Gene end: 1876047
  
Corresponding Affymetrix probe sets: Gga.4871.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000000468
NCBI entrez gene - 428274     See in Manteia.
RefSeq - NM_001292069
RefSeq Peptide - NP_001278998
swissprot - F1NU79
Ensembl - ENSGALG00000000349
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 psmc5ENSDARG00000015315Danio rerio
 PSMC5ENSG00000087191Homo sapiens
 Psmc5ENSMUSG00000020708Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003593  AAA+ ATPase domain
 IPR003959  ATPase, AAA-type, core
 IPR003960  ATPase, AAA-type, conserved site
 IPR005937  26S proteasome regulatory subunit P45-like
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0030163 protein catabolic process IEA
 biological_processGO:0030433 ubiquitin-dependent ERAD pathway IBA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly IBA
 biological_processGO:1901800 positive regulation of proteasomal protein catabolic process IEA
 cellular_componentGO:0000502 proteasome complex IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005838 proteasome regulatory particle IEA
 cellular_componentGO:0008540 proteasome regulatory particle, base subcomplex IBA
 cellular_componentGO:0022624 proteasome accessory complex IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031595 nuclear proteasome complex IBA
 cellular_componentGO:0031597 cytosolic proteasome complex IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017025 TBP-class protein binding IBA
 molecular_functionGO:0031531 thyrotropin-releasing hormone receptor binding IEA
 molecular_functionGO:0036402 proteasome-activating ATPase activity IBA


Pathways (from Reactome)
Pathway description
GLI3 is processed to GLI3R by the proteasome
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Regulation of RUNX3 expression and activity
MAPK6/MAPK4 signaling
TNFR2 non-canonical NF-kB pathway
Neddylation
SCF-beta-TrCP mediated degradation of Emi1
Autodegradation of Cdh1 by Cdh1:APC/C
Regulation of PTEN stability and activity
Regulation of RUNX2 expression and activity
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Autodegradation of the E3 ubiquitin ligase COP1
FCERI mediated NF-kB activation
Separation of Sister Chromatids
Degradation of beta-catenin by the destruction complex
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Cross-presentation of soluble exogenous antigens (endosomes)
AUF1 (hnRNP D0) binds and destabilizes mRNA
ABC-family proteins mediated transport
Activation of NF-kappaB in B cells
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
APC/C:Cdc20 mediated degradation of Securin
Antigen processing: Ubiquitination & Proteasome degradation
Asymmetric localization of PCP proteins
CLEC7A (Dectin-1) signaling
CDT1 association with the CDC6:ORC:origin complex
CDK-mediated phosphorylation and removal of Cdc6
Degradation of GLI1 by the proteasome
Degradation of DVL
Degradation of AXIN
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Downstream TCR signaling
Hedgehog on state
Hedgehog ligand biogenesis
Interleukin-1 signaling
Orc1 removal from chromatin
Regulation of RAS by GAPs
Regulation of ornithine decarboxylase (ODC)
SCF(Skp2)-mediated degradation of p27/p21
Ub-specific processing proteases
UCH proteinases
Ubiquitin-dependent degradation of Cyclin D1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000005931 RUVBL1 / ruvB-like 1 / Q9Y265* / P60122* / RuvB-like protein 1* / RuvB like AAA ATPase 1*  / complex
 ENSGALG00000017052 CCNA1 / cyclin A1 / P78396* / Q61456*  / complex






 

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