ENSGALG00000000802


Gallus gallus
dihydroorotateactivityDHODHdenovoprocesspyrimidinebiosyntheticumpmembraneoxidoreductaseconservedsiteclassdomainaldolase-typetimbarrelnucleobaseoxidation-reductionnucleoplasmcytoplasmmitochondrionmitochondrialinnercytosolcatalyticactingch-chgroup

Features
Gene ID: ENSGALG00000000802
  
Biological name :DHODH
  
Synonyms : DHODH / dihydroorotate dehydrogenase (quinone)
  
Possible biological names infered from orthology : Dihydroorotate dehydrogenase (quinone), mitochondrial / O35435 / Q02127
  
Species: Gallus gallus
  
Chr. number: 11
Strand: -1
Band:
Gene start: 19961318
Gene end: 19964884
  
Corresponding Affymetrix probe sets: Gga.4705.2.S1_at (Chicken Array)   Gga.4705.2.S1_s_at (Chicken Array)   GgaAffx.13107.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000063565
Ensembl peptide - ENSGALP00000001161
NCBI entrez gene - 415876     See in Manteia.
RefSeq - NM_001006131
RefSeq Peptide - NP_001006131
swissprot - Q5ZHY0
swissprot - A0A1L1RXI8
Ensembl - ENSGALG00000000802
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dhodhENSDARG00000051889Danio rerio
 DHODHENSG00000102967Homo sapiens
 DhodhENSMUSG00000031730Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001295  Dihydroorotate dehydrogenase, conserved site
 IPR005719  Dihydroorotate dehydrogenase, class 2
 IPR005720  Dihydroorotate dehydrogenase domain
 IPR013785  Aldolase-type TIM barrel


Gene Ontology (GO)
nitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processoxidation-reduction processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processoxidation-reduction processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processoxidation-reduction processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processoxidation-reduction processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processoxidation-reduction processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processoxidation-reduction processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processoxidation-reduction processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processoxidation-reduction processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processoxidation-reduction processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processoxidation-reduction processnitrogen compound menitrogen compound metabolic processbiosynthetic processbiosynthetic processcellular metabolic pcellular metabolic processprimary metabolic prprimary metabolic processsmall molecule metabsmall molecule metabolic processorganic substance meorganic substance metabolic processoxidation-reduction oxidation-reduction process
oxidoreductase activityoxidoreductase activityoxidoreductase activityoxidoreductase activityoxidoreductase activityoxidoreductase activityoxidoreductase activityoxidoreductase activityoxidoreductase activityoxidoreductase activityoxidoreductase activityoxidoreductase activity
cellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellcellorganelleorganellemembrane-enclosed lumenmembrane-enclosed lumenmembranemembrane
TypeGO IDTermEv.Code
 biological_processGO:0006207 "de novo" pyrimidine nucleobase biosynthetic process IEA
 biological_processGO:0044205 "de novo" UMP biosynthetic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004152 dihydroorotate dehydrogenase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016627 oxidoreductase activity, acting on the CH-CH group of donors IEA


Pathways (from Reactome)
Pathway description
De novo synthesis of UMP
Pyrimidine biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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