ENSGALG00000001798


Gallus gallus
regulationBBS4ciliumdevelopmentproteinphotoreceptorlocalizationassemblycentrosomecellsegmentciliarybindingmicrotubuleouternon-motiledomaintetratricopeptideorganizationcytokinesisbehaviorleptin-mediatedsignalingpathwayactivityfatmaintenancenucleusmembranetetratricopeptide-likehelical

Features
Gene ID: ENSGALG00000001798
  
Biological name :BBS4
  
Synonyms : Bardet-Biedl syndrome 4 protein / BBS4
  
Possible biological names infered from orthology : Bardet-Biedl syndrome 4 / Bardet-Biedl syndrome 4 protein homolog / Q8C1Z7 / Q96RK4
  
Species: Gallus gallus
  
Chr. number: 10
Strand: 1
Band:
Gene start: 1612983
Gene end: 1647497
  
Corresponding Affymetrix probe sets: Gga.12577.1.S1_at (Chicken Array)   Gga.12577.2.S1_a_at (Chicken Array)   Gga.7400.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000002771
Ensembl peptide - ENSGALP00000062126
Ensembl peptide - ENSGALP00000059096
Ensembl peptide - ENSGALP00000046263
NCBI entrez gene - 415318     See in Manteia.
RefSeq - NM_001277458
RefSeq Peptide - NP_001264387
swissprot - A0A1L1RTI4
swissprot - A0A1L1RK09
swissprot - A0A1D5P0T4
swissprot - F1NGP6
Ensembl - ENSGALG00000001798
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bbs4ENSDARG00000063522Danio rerio
 BBS4ENSG00000140463Homo sapiens
 Bbs4ENSMUSG00000025235Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TTC8 / tetratricopeptide repeat domain 8 / Q8TAM2* / Q8VD72*ENSGALG0000001066316


Protein motifs (from Interpro)
Interpro ID Name
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013026  Tetratricopeptide repeat-containing domain
 IPR019734  Tetratricopeptide repeat


Gene Ontology (GO)
cellular component organizationmicrotubule-based processcell cyclecell divisionlocalization of cellmovement of cell or subcellular componentanatomical structure developmentcellular developmental processregulation of biological qualitysystem processmulticellular organism reproductionmacromolecule localizationorganic substance metabolic processprimary metabolic processadult behaviorcellular component biogenesisactin filament-based processcell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimuluscellular localizationregulation of molecular functionintraspecies interaction between organismsmulti-organism behaviorresponse to external stimulusdevelopmental growthcellular component organizationmicrotubule-based processcell cyclecell divisionlocalization of cellmovement of cell or subcellular componentanatomical structure developmentcellular developmental processregulation of biological qualitysystem processmulticellular organism reproductionmacromolecule localizationorganic substance metabolic processprimary metabolic processadult behaviorcellular component biogenesisactin filament-based processcell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimuluscellular localizationregulation of molecular functionintraspecies interaction between organismsmulti-organism behaviorresponse to external stimulusdevelopmental growthcellular component organizationmicrotubule-based processcell cyclecell divisionlocalization of cellmovement of cell or subcellular componentanatomical structure developmentcellular developmental processregulation of biological qualitysystem processmulticellular organism reproductionmacromolecule localizationorganic substance metabolic processprimary metabolic processadult behaviorcellular component biogenesisactin filament-based processcell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimuluscellular localizationregulation of molecular functionintraspecies interaction between organismsmulti-organism behaviorresponse to external stimulusdevelopmental growthcellular component organizationmicrotubule-based processcell cyclecell divisionlocalization of cellmovement of cell or subcellular componentanatomical structure developmentcellular developmental processregulation of biological qualitysystem processmulticellular organism reproductionmacromolecule localizationorganic substance metabolic processprimary metabolic processadult behaviorcellular component biogenesisactin filament-based processcell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimuluscellular localizationregulation of molecular functionintraspecies interaction between organismsmulti-organism behaviorresponse to external stimulusdevelopmental growthcellular component organizationmicrotubule-based processcell cyclecell divisionlocalization of cellmovement of cell or subcellular componentanatomical structure developmentcellular developmental processregulation of biological qualitysystem processmulticellular organism reproductionmacromolecule localizationorganic substance metabolic processprimary metabolic processadult behaviorcellular component biogenesisactin filament-based processcell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimuluscellular localizationregulation of molecular functionintraspecies interaction between organismsmulti-organism behaviorresponse to external stimulusdevelopmental growthcellular component organizationmicrotubule-based processcell cyclecell divisionlocalization of cellmovement of cell or subcellular componentanatomical structure developmentcellular developmental processregulation of biological qualitysystem processmulticellular organism reproductionmacromolecule localizationorganic substance metabolic processprimary metabolic processadult behaviorcellular component biogenesisactin filament-based processcell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimuluscellular localizationregulation of molecular functionintraspecies interaction between organismsmulti-organism behaviorresponse to external stimulusdevelopmental growthcellular component organizationmicrotubule-based processcell cyclecell divisionlocalization of cellmovement of cell or subcellular componentanatomical structure developmentcellular developmental processregulation of biological qualitysystem processmulticellular organism reproductionmacromolecule localizationorganic substance metabolic processprimary metabolic processadult behaviorcellular component biogenesisactin filament-based processcell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimuluscellular localizationregulation of molecular functionintraspecies interaction between organismsmulti-organism behaviorresponse to external stimulusdevelopmental growthcellular component organizationmicrotubule-based processcell cyclecell divisionlocalization of cellmovement of cell or subcellular componentanatomical structure developmentcellular developmental processregulation of biological qualitysystem processmulticellular organism reproductionmacromolecule localizationorganic substance metabolic processprimary metabolic processadult behaviorcellular component biogenesisactin filament-based processcell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimuluscellular localizationregulation of molecular functionintraspecies interaction between organismsmulti-organism behaviorresponse to external stimulusdevelopmental growthcellular component organizationmicrotubule-based processcell cyclecell divisionlocalization of cellmovement of cell or subcellular componentanatomical structure developmentcellular developmental processregulation of biological qualitysystem processmulticellular organism reproductionmacromolecule localizationorganic substance metabolic processprimary metabolic processadult behaviorcellular component biogenesisactin filament-based processcell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimuluscellular localizationregulation of molecular functionintraspecies interaction between organismsmulti-organism behaviorresponse to external stimulusdevelopmental growthcellular component organizationmicrotubule-based processcell cyclecell divisionlocalization of cellmovement of cell or subcellular componentanatomical structure developmentcellular developmental processregulation of biological qualitysystem processmulticellular organism reproductionmacromolecule localizationorganic substance metabolic processprimary metabolic processadult behaviorcellular component biogenesisactin filament-based processcell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimuluscellular localizationregulation of molecular functionintraspecies interaction between organismsmulti-organism behaviorresponse to external stimulusdevelopmental growthcellucellular component organizationmicromicrotubule-based processcell cell cyclecell cell divisionlocallocalization of cellmovemmovement of cell or subcellular componentanatoanatomical structure developmentcellucellular developmental processregulregulation of biological qualitysystesystem processmultimulticellular organism reproductionmacromacromolecule localizationorganorganic substance metabolic processprimaprimary metabolic processadultadult behaviorcellucellular component biogenesisactinactin filament-based processcell cell communicationresporesponse to endogenous stimulusresporesponse to chemicalcellucellular response to stimuluscellucellular localizationregulregulation of molecular functionintraintraspecies interaction between organismsmultimulti-organism behaviorresporesponse to external stimulusdeveldevelopmental growth
protein bindinghydrolase activityprotein bindinghydrolase activityprotein bindinghydrolase activityprotein bindinghydrolase activityprotein bindinghydrolase activityprotein bindinghydrolase activityprotein bindinghydrolase activityprotein bindinghydrolase activityprotein bindinghydrolase activityprotein bindinghydrolase activityprotein bindingprotein bindinghydrolase activityhydrolase activity
cellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellcellorganelleorganellemembranemembraneprotein-containing complexprotein-containing complex
TypeGO IDTermEv.Code
 biological_processGO:0000226 microtubule cytoskeleton organization IEA
 biological_processGO:0000281 mitotic cytokinesis IEA
 biological_processGO:0001764 neuron migration IEA
 biological_processGO:0001843 neural tube closure IEA
 biological_processGO:0001895 retina homeostasis IEA
 biological_processGO:0003085 negative regulation of systemic arterial blood pressure IEA
 biological_processGO:0007098 centrosome cycle IEA
 biological_processGO:0007286 spermatid development IEA
 biological_processGO:0007608 sensory perception of smell IEA
 biological_processGO:0008104 protein localization IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0016358 dendrite development IEA
 biological_processGO:0019216 regulation of lipid metabolic process IEA
 biological_processGO:0021591 ventricular system development IEA
 biological_processGO:0021756 striatum development IEA
 biological_processGO:0021766 hippocampus development IEA
 biological_processGO:0021987 cerebral cortex development IEA
 biological_processGO:0030534 adult behavior IEA
 biological_processGO:0030837 negative regulation of actin filament polymerization IEA
 biological_processGO:0032465 regulation of cytokinesis IEA
 biological_processGO:0033210 leptin-mediated signaling pathway IEA
 biological_processGO:0033365 protein localization to organelle IEA
 biological_processGO:0034260 negative regulation of GTPase activity IEA
 biological_processGO:0034454 microtubule anchoring at centrosome IEA
 biological_processGO:0035176 social behavior IEA
 biological_processGO:0035845 photoreceptor cell outer segment organization IEA
 biological_processGO:0038108 negative regulation of appetite by leptin-mediated signaling pathway IEA
 biological_processGO:0040018 positive regulation of multicellular organism growth IEA
 biological_processGO:0044321 response to leptin IEA
 biological_processGO:0045444 fat cell differentiation IEA
 biological_processGO:0045494 photoreceptor cell maintenance IEA
 biological_processGO:0045724 positive regulation of cilium assembly IEA
 biological_processGO:0046548 retinal rod cell development IEA
 biological_processGO:0048854 brain morphogenesis IEA
 biological_processGO:0051457 maintenance of protein location in nucleus IEA
 biological_processGO:0051492 regulation of stress fiber assembly IEA
 biological_processGO:0060271 cilium assembly IEA
 biological_processGO:0060296 regulation of cilium beat frequency involved in ciliary motility IEA
 biological_processGO:0060324 face development IEA
 biological_processGO:0060613 fat pad development IEA
 biological_processGO:0061512 protein localization to cilium IEA
 biological_processGO:0071539 protein localization to centrosome IEA
 biological_processGO:1902855 regulation of non-motile cilium assembly IEA
 biological_processGO:1903546 protein localization to photoreceptor outer segment IEA
 biological_processGO:1905515 non-motile cilium assembly IEA
 cellular_componentGO:0000242 pericentriolar material IEA
 cellular_componentGO:0001750 photoreceptor outer segment IEA
 cellular_componentGO:0001917 photoreceptor inner segment IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005814 centriole IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031514 motile cilium IEA
 cellular_componentGO:0032391 photoreceptor connecting cilium IEA
 cellular_componentGO:0034451 centriolar satellite IEA
 cellular_componentGO:0034464 BBSome IEA
 cellular_componentGO:0035869 ciliary transition zone IEA
 cellular_componentGO:0036064 ciliary basal body IEA
 cellular_componentGO:0060170 ciliary membrane IEA
 cellular_componentGO:0097730 non-motile cilium IEA
 molecular_functionGO:0001103 RNA polymerase II repressing transcription factor binding IEA
 molecular_functionGO:0003777 microtubule motor activity IEA
 molecular_functionGO:0034452 dynactin binding IEA
 molecular_functionGO:0043014 alpha-tubulin binding IEA
 molecular_functionGO:0048487 beta-tubulin binding IEA


Pathways (from Reactome)
Pathway description
BBSome-mediated cargo-targeting to cilium


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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