ENSGALG00000002193


Gallus gallus

Features
Gene ID: ENSGALG00000002193
  
Biological name :ARHGEF4
  
Synonyms : ARHGEF4 / Rho guanine nucleotide exchange factor 4
  
Possible biological names infered from orthology : Q7TNR9 / Q9NR80
  
Species: Gallus gallus
  
Chr. number: 9
Strand: -1
Band:
Gene start: 2275486
Gene end: 2312749
  
Corresponding Affymetrix probe sets: GgaAffx.25421.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000003426
swissprot - F1NVB0
Ensembl - ENSGALG00000002193
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arhgef4ENSDARG00000012914Danio rerio
 Q9NR80ENSG00000136002Homo sapiens
 Q7TNR9ENSMUSG00000037509Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q96N96* / SPATA13* / AL359736.1* / spermatogenesis associated 13*ENSGALG0000003467459
ARHGEF9 / Cdc42 guanine nucleotide exchange factor 9 / O43307* / Q3UTH8* / Rho guanine nucleotide exchange factor 9 *ENSGALG0000000760854
PREX1 / phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 / Q69ZK0* / Q8TCU6* / Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein *ENSGALG0000000462129
PREX2 / phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2 / Q3LAC4* / Q70Z35* / Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein *ENSGALG0000004235426
VAV2 / guanine nucleotide exchange factor VAV2 / Q60992* / P52735* / vav 2 oncogene* / vav guanine nucleotide exchange factor 2*ENSGALG0000000269920
Q5ZLR6 / ARHGEF6 / Rho guanine nucleotide exchange factor 6 / Q15052* / Rac/Cdc42 guanine nucleotide exchange factor 6*ENSGALG0000000643920
TIAM1 / T cell lymphoma invasion and metastasis 1 / Q13009*ENSGALG0000001584220
TIAM2 / T cell lymphoma invasion and metastasis 2 / Q6ZPF3* / Q8IVF5* / T-lymphoma invasion and metastasis-inducing protein 2 *ENSGALG0000003600520
ARHGEF7 / Rho guanine nucleotide exchange factor 7 / Q14155* / Q9ES28*ENSGALG0000003100919
VAV3 / vav guanine nucleotide exchange factor 3 / Q9R0C8* / Q9UKW4* / vav 3 oncogene*ENSGALG0000003932718
ENSGALG000000018948
ENSGALG000000362531


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001331  Guanine-nucleotide dissociation stimulator, CDC24, conserved site
 IPR001452  SH3 domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0030032 lamellipodium assembly IEA
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0046847 filopodium assembly IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0030676 Rac guanyl-nucleotide exchange factor activity IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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