ENSGALG00000002246


Gallus gallus
domainrabDENND1Bcellregulationgtpaseactivityexchangecdennddennudennendocyticrecyclingt-helpercytokineproductionimmuneresponsetreceptorsignalingpathwaycytosolnuclearspeckguanyl-nucleotidefactorbindinggefsgtpgdp

Features
Gene ID: ENSGALG00000002246
  
Biological name :DENND1B
  
Synonyms : DENND1B / DENN domain containing 1B
  
Possible biological names infered from orthology : DENN domain-containing protein 1B / Q3U1T9 / Q6P3S1
  
Species: Gallus gallus
  
Chr. number: 8
Strand: 1
Band:
Gene start: 2339757
Gene end: 2479306
  
Corresponding Affymetrix probe sets: Gga.10102.1.S1_s_at (Chicken Array)   GgaAffx.1492.1.S1_at (Chicken Array)   GgaAffx.1493.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000056842
Ensembl peptide - ENSGALP00000003510
NCBI entrez gene - 424351     See in Manteia.
RefSeq - XM_015290379
RefSeq - XM_015290377
RefSeq - XM_015290378
RefSeq - XM_015290375
RefSeq - XM_015290376
swissprot - F1P3Z3
swissprot - A0A1D5PV81
Ensembl - ENSGALG00000002246
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dennd1bENSDARG00000101868Danio rerio
 Q6P3S1ENSG00000213047Homo sapiens
 Q3U1T9ENSMUSG00000056268Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DENND1A / DENN domain containing 1A / Q8K382* / Q8TEH3* / DENN domain-containing protein 1A *ENSGALG0000000115745
DENND4C / DENN domain containing 4C / A6H8H2* / Q5VZ89* / DENN domain-containing protein 4C *ENSGALG0000001508319
DENND4A / DENN domain containing 4A / Q7Z401*ENSGALG0000004140318
DENND5A / DENN domain containing 5A / Q6IQ26* / Q6PAL8* / DENN domain-containing protein 5A *ENSGALG0000000584016
DENND2A / DENN domain containing 2A / Q8C4S8* / Q9ULE3* / DENN domain-containing protein 2A *ENSGALG0000001285716
DENND2C / DENN domain containing 2C / Q68D51*ENSGALG0000000203815
MADD / MAP kinase activating death domain / Q8WXG6*ENSGALG0000000818115
DENND3 / DENN domain containing 3 / A2RT67* / A2RUS2* / DENN domain-containing protein 3 *ENSGALG0000003138014
DENND2D / DENN domain containing 2D / Q91VV4* / Q9H6A0* / DENN domain-containing protein 2D *ENSGALG0000000015413
A2RSQ0* / Q6ZUT9* / DENND5B* / DENN domain containing 5B* / DENN domain-containing protein 5B *ENSGALG0000001294412
ENSGALG0000000592711
A2RSQ0* / Q6ZUT9* / DENND5B* / DENN domain containing 5B* / DENN domain-containing protein 5B *ENSGALG000000459904
ENSGALG000000303742


Protein motifs (from Interpro)
Interpro ID Name
 IPR001194  cDENN domain
 IPR005112  dDENN domain
 IPR005113  uDENN domain


Gene Ontology (GO)
establishment of localizationcellular localizationimmune responseproduction of molecular mediator of immune responsecytokine productionimmune effector processregulation of molecular functioncell communicationcellular response to stimulusestablishment of localizationcellular localizationimmune responseproduction of molecular mediator of immune responsecytokine productionimmune effector processregulation of molecular functioncell communicationcellular response to stimulusestablishment of localizationcellular localizationimmune responseproduction of molecular mediator of immune responsecytokine productionimmune effector processregulation of molecular functioncell communicationcellular response to stimulusestablishment of localizationcellular localizationimmune responseproduction of molecular mediator of immune responsecytokine productionimmune effector processregulation of molecular functioncell communicationcellular response to stimulusestablishment of localizationcellular localizationimmune responseproduction of molecular mediator of immune responsecytokine productionimmune effector processregulation of molecular functioncell communicationcellular response to stimulusestablishment of localizationcellular localizationimmune responseproduction of molecular mediator of immune responsecytokine productionimmune effector processregulation of molecular functioncell communicationcellular response to stimulusestablishment of localizationcellular localizationimmune responseproduction of molecular mediator of immune responsecytokine productionimmune effector processregulation of molecular functioncell communicationcellular response to stimulusestablishment of localizationcellular localizationimmune responseproduction of molecular mediator of immune responsecytokine productionimmune effector processregulation of molecular functioncell communicationcellular response to stimulusestablishment of localizationcellular localizationimmune responseproduction of molecular mediator of immune responsecytokine productionimmune effector processregulation of molecular functioncell communicationcellular response to stimulusestablishment of localizationcellular localizationimmune responseproduction of molecular mediator of immune responsecytokine productionimmune effector processregulation of molecular functioncell communicationcellular response to stimulusestablishment oestablishment of localizationcellular localicellular localizationimmune responseimmune responseproduction of mproduction of molecular mediator of immune responsecytokine produccytokine productionimmune effectorimmune effector processregulation of mregulation of molecular functioncell communicatcell communicationcellular responcellular response to stimulus
protein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein binding
cellorganellemembrane-enclosed lumencellorganellemembrane-enclosed lumencellorganellemembrane-enclosed lumencellorganellemembrane-enclosed lumencellorganellemembrane-enclosed lumencellorganellemembrane-enclosed lumencellorganellemembrane-enclosed lumencellorganellemembrane-enclosed lumencellorganellemembrane-enclosed lumencellorganellemembrane-enclosed lumencellcellorganelleorganellemembrane-enclosed lumenmembrane-enclosed lumen
TypeGO IDTermEv.Code
 biological_processGO:0032456 endocytic recycling IEA
 biological_processGO:0035745 T-helper 2 cell cytokine production IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0050776 regulation of immune response IEA
 biological_processGO:0050852 T cell receptor signaling pathway IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016607 nuclear speck IEA
 molecular_functionGO:0017112 Rab guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0017137 Rab GTPase binding IEA


Pathways (from Reactome)
Pathway description
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000007308 RAB35 / RAB35, member RAS oncogene family / Q15286* / Q6PHN9*  / reaction






 

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