ENSGALG00000002937


Gallus gallus

Features
Gene ID: ENSGALG00000002937
  
Biological name :PSME3
  
Synonyms : Proteasome activator complex subunit 3 / PSME3 / Q5F3J5
  
Possible biological names infered from orthology : P61289 / P61290 / proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki) / proteasome activator subunit 3
  
Species: Gallus gallus
  
Chr. number: 27
Strand: 1
Band:
Gene start: 5483514
Gene end: 5490234
  
Corresponding Affymetrix probe sets: Gga.5999.1.S1_s_at (Chicken Array)   Gga.5999.2.S1_at (Chicken Array)   Gga.5999.3.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000038984
Ensembl peptide - ENSGALP00000062649
Ensembl peptide - ENSGALP00000057745
NCBI entrez gene - 420017     See in Manteia.
RefSeq - NM_001012550
RefSeq Peptide - NP_001012568
swissprot - A0A1L1RUZ3
swissprot - A0A1D5PXP8
swissprot - Q5F3J5
Ensembl - ENSGALG00000002937
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 psme3ENSDARG00000012234Danio rerio
 PSME3ENSG00000131467Homo sapiens
 Psme3ENSMUSG00000078652Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003185  Proteasome activator PA28, N-terminal domain
 IPR003186  Proteasome activator PA28, C-terminal domain
 IPR009077  Proteasome activator PA28


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010950 positive regulation of endopeptidase activity IBA
 biological_processGO:0061136 regulation of proteasomal protein catabolic process IEA
 biological_processGO:2000045 regulation of G1/S transition of mitotic cell cycle IBA
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0000502 proteasome complex IBA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0008537 proteasome activator complex IEA
 molecular_functionGO:0002039 p53 binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0061133 endopeptidase activator activity IEA
 molecular_functionGO:0097371 MDM2/MDM4 family protein binding IEA


Pathways (from Reactome)
Pathway description
GLI3 is processed to GLI3R by the proteasome
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Regulation of RUNX3 expression and activity
MAPK6/MAPK4 signaling
TNFR2 non-canonical NF-kB pathway
Neddylation
SCF-beta-TrCP mediated degradation of Emi1
Autodegradation of Cdh1 by Cdh1:APC/C
Regulation of PTEN stability and activity
Regulation of RUNX2 expression and activity
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Autodegradation of the E3 ubiquitin ligase COP1
FCERI mediated NF-kB activation
Separation of Sister Chromatids
Degradation of beta-catenin by the destruction complex
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Cross-presentation of soluble exogenous antigens (endosomes)
AUF1 (hnRNP D0) binds and destabilizes mRNA
ABC-family proteins mediated transport
Activation of NF-kappaB in B cells
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
APC/C:Cdc20 mediated degradation of Securin
Antigen processing: Ubiquitination & Proteasome degradation
Asymmetric localization of PCP proteins
CLEC7A (Dectin-1) signaling
CDT1 association with the CDC6:ORC:origin complex
CDK-mediated phosphorylation and removal of Cdc6
Degradation of GLI1 by the proteasome
Degradation of DVL
Degradation of AXIN
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Downstream TCR signaling
Hedgehog on state
Hedgehog ligand biogenesis
Interleukin-1 signaling
Orc1 removal from chromatin
Regulation of RAS by GAPs
Regulation of ornithine decarboxylase (ODC)
SCF(Skp2)-mediated degradation of p27/p21
Ub-specific processing proteases
UCH proteinases
Ubiquitin-dependent degradation of Cyclin D1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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