ENSGALG00000003500


Gallus gallus
regulationsignalingtsccomplexhamartintoractincytoskeletonorganizationgtpaseactivityinsulinreceptorpathwaycellcycle-tscmacroautophagyinhibitionformationpkbenergydependentmtorlkb-ampktpregulatesmetabolicgenes

Features
Gene ID: ENSGALG00000003500
  
Biological name :
  
Synonyms :
  
Possible biological names infered from orthology : Hamartin / Q92574 / Q9EP53 / TSC1 / TSC complex subunit 1
  
Species: Gallus gallus
  
Chr. number: 17
Strand: -1
Band:
Gene start: 7209219
Gene end: 7217145
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSGALP00000005527
swissprot - E1C066
Ensembl - ENSGALG00000003500
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tsc1aENSDARG00000026048Danio rerio
 tsc1bENSDARG00000057918Danio rerio
 TSC1ENSG00000165699Homo sapiens
 Tsc1ENSMUSG00000026812Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TSC1* / Q92574* / Q9EP53* / Hamartin * / TSC complex subunit 1*ENSGALG000000435480


Protein motifs (from Interpro)
Interpro ID Name
 IPR007483  Hamartin


Gene Ontology (GO)
cell communicationcellular response to stimuluscellular component organizationactin filament-based processregulation of molecular functionresponse to endogenous stimulusresponse to chemicalcell cyclecell communicationcellular response to stimuluscellular component organizationactin filament-based processregulation of molecular functionresponse to endogenous stimulusresponse to chemicalcell cyclecell communicationcellular response to stimuluscellular component organizationactin filament-based processregulation of molecular functionresponse to endogenous stimulusresponse to chemicalcell cyclecell communicationcellular response to stimuluscellular component organizationactin filament-based processregulation of molecular functionresponse to endogenous stimulusresponse to chemicalcell cyclecell communicationcellular response to stimuluscellular component organizationactin filament-based processregulation of molecular functionresponse to endogenous stimulusresponse to chemicalcell cyclecell communicationcellular response to stimuluscellular component organizationactin filament-based processregulation of molecular functionresponse to endogenous stimulusresponse to chemicalcell cyclecell communicationcellular response to stimuluscellular component organizationactin filament-based processregulation of molecular functionresponse to endogenous stimulusresponse to chemicalcell cyclecell communicationcellular response to stimuluscellular component organizationactin filament-based processregulation of molecular functionresponse to endogenous stimulusresponse to chemicalcell cyclecell communicationcellular response to stimuluscellular component organizationactin filament-based processregulation of molecular functionresponse to endogenous stimulusresponse to chemicalcell cyclecell communicationcellular response to stimuluscellular component organizationactin filament-based processregulation of molecular functionresponse to endogenous stimulusresponse to chemicalcell cyclecell communicatiocell communicationcellular responsecellular response to stimuluscellular componencellular component organizationactin filament-baactin filament-based processregulation of molregulation of molecular functionresponse to endogresponse to endogenous stimulusresponse to chemiresponse to chemicalcell cyclecell cycle
cellprotein-containing complexcellprotein-containing complexcellprotein-containing complexcellprotein-containing complexcellprotein-containing complexcellprotein-containing complexcellprotein-containing complexcellprotein-containing complexcellprotein-containing complexcellprotein-containing complexcellcellprotein-containing complexprotein-containing complex
TypeGO IDTermEv.Code
 biological_processGO:0032007 negative regulation of TOR signaling IBA
 biological_processGO:0032956 regulation of actin cytoskeleton organization IBA
 biological_processGO:0043087 regulation of GTPase activity IBA
 biological_processGO:0046627 negative regulation of insulin receptor signaling pathway IBA
 biological_processGO:0051726 regulation of cell cycle IBA
 cellular_componentGO:0033596 TSC1-TSC2 complex IBA


Pathways (from Reactome)
Pathway description
Macroautophagy
Inhibition of TSC complex formation by PKB
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
TBC/RABGAPs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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