ENSGALG00000005617


Gallus gallus

Features
Gene ID: ENSGALG00000005617
  
Biological name :NTHL1
  
Synonyms : A7M7B9 / Endonuclease III-like protein 1 / NTHL1
  
Possible biological names infered from orthology : nth (endonuclease III)-like 1 (E.coli) / nth like DNA glycosylase 1 / O35980 / P78549
  
Species: Gallus gallus
  
Chr. number: 14
Strand: -1
Band:
Gene start: 6300690
Gene end: 6305628
  
Corresponding Affymetrix probe sets: Gga.11851.1.S1_at (Chicken Array)   Gga.11851.3.S1_a_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000008999
NCBI entrez gene - 416551     See in Manteia.
RefSeq - NM_001079575
RefSeq Peptide - NP_001073043
swissprot - A7M7B9
Ensembl - ENSGALG00000005617
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nthl1ENSDARG00000042881Danio rerio
 NTHL1ENSG00000065057Homo sapiens
 Nthl1ENSMUSG00000041429Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000445  Helix-hairpin-helix motif
 IPR003265  HhH-GPD domain
 IPR004035  Endonuclease III, iron-sulphur binding site
 IPR004036  Endonuclease III-like, conserved site-2
 IPR011257  DNA glycosylase
 IPR023170  Helix-turn-helix, base-excision DNA repair, C-terminal
 IPR030841  Endonuclease III-like protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006284 base-excision repair IEA
 biological_processGO:0006285 base-excision repair, AP site formation IBA
 biological_processGO:0006296 nucleotide-excision repair, DNA incision, 5"-to lesion IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0008152 metabolic process IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005739 mitochondrion IBA
 molecular_functionGO:0000703 oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016798 hydrolase activity, acting on glycosyl bonds IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0019104 DNA N-glycosylase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051536 iron-sulfur cluster binding IEA
 molecular_functionGO:0051539 4 iron, 4 sulfur cluster binding IEA
 molecular_functionGO:0140078 class I DNA-(apurinic or apyrimidinic site) endonuclease activity IEA
 molecular_functionGO:0140080 class III/IV DNA-(apurinic or apyrimidinic site) endonuclease activity IEA


Pathways (from Reactome)
Pathway description
Cleavage of the damaged pyrimidine


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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