ENSGALG00000005622


Gallus gallus
proteinARF4smallregulationbindinggtpasesuperfamilyarftyperetrogradetransportgolgicellprocessapicallocalizationdendriticspineciliummembranegtp-bindingdomainsarp-loopcontainingnucleosidetriphosphatehydrolaseadp-ribosylationvesicle-mediateder

Features
Gene ID: ENSGALG00000005622
  
Biological name :ARF4
  
Synonyms : ADP ribosylation factor 4 / ARF4
  
Possible biological names infered from orthology : P18085 / P61750
  
Species: Gallus gallus
  
Chr. number: 12
Strand: -1
Band:
Gene start: 8722023
Gene end: 8732436
  
Corresponding Affymetrix probe sets: Gga.6997.1.S1_s_at (Chicken Array)   Gga.6997.2.A1_at (Chicken Array)   Gga.6997.2.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000009007
Ensembl peptide - ENSGALP00000044203
NCBI entrez gene - 769725     See in Manteia.
RefSeq - XM_015293388
swissprot - A0A1D5NV30
swissprot - F1NGS7
Ensembl - ENSGALG00000005622
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ARF4ENSG00000168374Homo sapiens
 Arf4ENSMUSG00000021877Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ARF1 / ADP-ribosylation factor 1 / P84077*ENSGALG0000000539380
ARF5 / ADP ribosylation factor 5 / P84084* / P84085*ENSGALG0000004347677
ARF6 / P26990 / ADP-ribosylation factor 6 / P62330* / P62331*ENSGALG0000002694463
TRIM23 / tripartite motif containing 23 / P36406* / Q8BGX0* / E3 ubiquitin-protein ligase TRIM23 *ENSGALG0000001476556
ARL3 / ADP ribosylation factor like GTPase 3 / P36405* / Q9WUL7* / ADP-ribosylation factor-like protein 3 *ENSGALG0000000804942
ARL14 / ADP ribosylation factor like GTPase 14 / Q8N4G2*ENSGALG0000004362341
ARL11 / ADP ribosylation factor like GTPase 11 / Q6P3A9* / Q969Q4* / ADP-ribosylation factor-like protein 11 *ENSGALG0000002273339
ENSGALG0000000313438
ARL8B / ADP ribosylation factor like GTPase 8B / Q9CQW2* / Q9NVJ2* / ADP-ribosylation factor-like protein 8B *ENSGALG0000000831431
ARL15 / ADP ribosylation factor like GTPase 15 / Q8BGR6* / Q9NXU5* / ADP-ribosylation factor-like protein 15 *ENSGALG0000001491130
ARL8A / ADP-ribosylation factor-like protein 8A / Q8VEH3* / Q96BM9* / ADP ribosylation factor like GTPase 8A*ENSGALG0000000060629
ARL8BLENSGALG0000003152727


Protein motifs (from Interpro)
Interpro ID Name
 IPR005225  Small GTP-binding protein domain
 IPR006689  Small GTPase superfamily, ARF/SAR type
 IPR024156  Small GTPase superfamily, ARF type
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
nitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processestablishment of localizationsystem processlocalization of cellmovement of cell or subcellular componentregulation of molecular functioncell deathmacromolecule localizationestablishment or maintenance of cell polaritybiosynthetic processcellular component organizationanatomical structure developmentcellular developmental processcellular localizationnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processestablishment of localizationsystem processlocalization of cellmovement of cell or subcellular componentregulation of molecular functioncell deathmacromolecule localizationestablishment or maintenance of cell polaritybiosynthetic processcellular component organizationanatomical structure developmentcellular developmental processcellular localizationnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processestablishment of localizationsystem processlocalization of cellmovement of cell or subcellular componentregulation of molecular functioncell deathmacromolecule localizationestablishment or maintenance of cell polaritybiosynthetic processcellular component organizationanatomical structure developmentcellular developmental processcellular localizationnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processestablishment of localizationsystem processlocalization of cellmovement of cell or subcellular componentregulation of molecular functioncell deathmacromolecule localizationestablishment or maintenance of cell polaritybiosynthetic processcellular component organizationanatomical structure developmentcellular developmental processcellular localizationnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processestablishment of localizationsystem processlocalization of cellmovement of cell or subcellular componentregulation of molecular functioncell deathmacromolecule localizationestablishment or maintenance of cell polaritybiosynthetic processcellular component organizationanatomical structure developmentcellular developmental processcellular localizationnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processestablishment of localizationsystem processlocalization of cellmovement of cell or subcellular componentregulation of molecular functioncell deathmacromolecule localizationestablishment or maintenance of cell polaritybiosynthetic processcellular component organizationanatomical structure developmentcellular developmental processcellular localizationnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processestablishment of localizationsystem processlocalization of cellmovement of cell or subcellular componentregulation of molecular functioncell deathmacromolecule localizationestablishment or maintenance of cell polaritybiosynthetic processcellular component organizationanatomical structure developmentcellular developmental processcellular localizationnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processestablishment of localizationsystem processlocalization of cellmovement of cell or subcellular componentregulation of molecular functioncell deathmacromolecule localizationestablishment or maintenance of cell polaritybiosynthetic processcellular component organizationanatomical structure developmentcellular developmental processcellular localizationnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processestablishment of localizationsystem processlocalization of cellmovement of cell or subcellular componentregulation of molecular functioncell deathmacromolecule localizationestablishment or maintenance of cell polaritybiosynthetic processcellular component organizationanatomical structure developmentcellular developmental processcellular localizationnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processestablishment of localizationsystem processlocalization of cellmovement of cell or subcellular componentregulation of molecular functioncell deathmacromolecule localizationestablishment or maintenance of cell polaritybiosynthetic processcellular component organizationanatomical structure developmentcellular developmental processcellular localizationnitrogennitrogen compound metabolic processcellularcellular metabolic processprimary primary metabolic processorganic organic substance metabolic processestablisestablishment of localizationsystem psystem processlocalizalocalization of cellmovementmovement of cell or subcellular componentregulatiregulation of molecular functioncell deacell deathmacromolmacromolecule localizationestablisestablishment or maintenance of cell polaritybiosynthbiosynthetic processcellularcellular component organizationanatomicanatomical structure developmentcellularcellular developmental processcellularcellular localization
organic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingprotein bindingion bindingcarbohydrate derivative bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingprotein bindingion bindingcarbohydrate derivative bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingprotein bindingion bindingcarbohydrate derivative bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingprotein bindingion bindingcarbohydrate derivative bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingprotein bindingion bindingcarbohydrate derivative bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingprotein bindingion bindingcarbohydrate derivative bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingprotein bindingion bindingcarbohydrate derivative bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingprotein bindingion bindingcarbohydrate derivative bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingprotein bindingion bindingcarbohydrate derivative bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingprotein bindingion bindingcarbohydrate derivative bindingorganic cyclic compoundorganic cyclic compound bindingheterocyclic compound bheterocyclic compound bindingsmall molecule bindingsmall molecule bindingprotein bindingprotein bindingion bindingion bindingcarbohydrate derivativecarbohydrate derivative binding
cellorganellemembranesynapsecellorganellemembranesynapsecellorganellemembranesynapsecellorganellemembranesynapsecellorganellemembranesynapsecellorganellemembranesynapsecellorganellemembranesynapsecellorganellemembranesynapsecellorganellemembranesynapsecellorganellemembranesynapsecellcellorganelleorganellemembranemembranesynapsesynapse
TypeGO IDTermEv.Code
 biological_processGO:0006471 protein ADP-ribosylation IEA
 biological_processGO:0006890 retrograde vesicle-mediated transport, Golgi to ER IEA
 biological_processGO:0007612 learning IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0031584 activation of phospholipase D activity IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045176 apical protein localization IEA
 biological_processGO:0045197 establishment or maintenance of epithelial cell apical/basal polarity IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0060996 dendritic spine development IEA
 biological_processGO:0061512 protein localization to cilium IEA
 biological_processGO:2000377 regulation of reactive oxygen species metabolic process IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0043197 dendritic spine IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005154 epidermal growth factor receptor binding IEA
 molecular_functionGO:0005525 GTP binding IEA


Pathways (from Reactome)
Pathway description
VxPx cargo-targeting to cilium
COPI-mediated anterograde transport
COPI-dependent Golgi-to-ER retrograde traffic


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000003153 COPE / Q5ZIK9 / Coatomer subunit epsilon / O14579* / O89079* / coatomer protein complex subunit epsilon*  / complex / reaction
 ENSGALG00000005357 COPB2 / coatomer protein complex subunit beta 2 / O55029* / P35606* / Coatomer subunit beta *  / complex / reaction
 ENSGALG00000005714 PKD1 / polycystin 1, transient receptor potential channel interacting / O08852* / P98161* / Polycystin-1 *  / complex / reaction
 ENSGALG00000007615 Q5ZJN2 / RAB11A / Ras-related protein Rab-11A / P62491* / P62492* / RAB11A, member RAS oncogene family*  / complex
 ENSGALG00000006015 COPB1 / Q5ZIA5 / Coatomer subunit beta / P53618* / Q9JIF7* / coatomer protein complex subunit beta 1*  / complex / reaction
 ENSGALG00000007430 ARCN1 / Q5ZL57 / Coatomer subunit delta / P48444* / Q5XJY5* / archain 1*  / complex / reaction
 ENSGALG00000037618 ASAP1 / ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 / Q9QWY8* / Q9ULH1* / Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 *  / complex






 

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