ENSGALG00000007244


Gallus gallus

Features
Gene ID: ENSGALG00000007244
  
Biological name :SIRT4
  
Synonyms : SIRT4 / sirtuin 4
  
Possible biological names infered from orthology : NAD-dependent protein lipoamidase sirtuin-4, mitochondrial / Q8R216 / Q9Y6E7
  
Species: Gallus gallus
  
Chr. number: 15
Strand: -1
Band:
Gene start: 9432753
Gene end: 9437165
  
Corresponding Affymetrix probe sets: Gga.18623.1.S1_at (Chicken Array)   Gga.5210.1.S1_at (Chicken Array)   GgaAffx.22182.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000011706
NCBI entrez gene - 416981     See in Manteia.
RefSeq - XM_015275354
swissprot - F1NB70
Ensembl - ENSGALG00000007244
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sirt4ENSDARG00000010415Danio rerio
 SIRT4ENSG00000089163Homo sapiens
 Sirt4ENSMUSG00000029524Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SIRT1 / NAD-dependent protein deacetylase sirtuin-1 / Q923E4* / Q96EB6* / sirtuin 1* / NAD-dependent protein deacetylase sirtuin-1 SirtT1 75 kDa fragment*ENSGALG0000000276125
SIRT5 / E1BRE2 / NAD-dependent protein deacylase sirtuin-5, mitochondrial / Q8K2C6* / Q9NXA8* / sirtuin 5*ENSGALG0000001269224


Protein motifs (from Interpro)
Interpro ID Name
 IPR003000  Sirtuin family
 IPR026587  Sirtuin, class II
 IPR026590  Sirtuin family, catalytic core domain
 IPR026591  Sirtuin, catalytic core small domain superfamily
 IPR029035  DHS-like NAD/FAD-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000820 regulation of glutamine family amino acid metabolic process IEA
 biological_processGO:0006471 protein ADP-ribosylation IEA
 biological_processGO:0006476 protein deacetylation IEA
 biological_processGO:0006541 glutamine metabolic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0034983 peptidyl-lysine deacetylation IEA
 biological_processGO:0046322 negative regulation of fatty acid oxidation IEA
 biological_processGO:0046676 negative regulation of insulin secretion IEA
 biological_processGO:0046889 positive regulation of lipid biosynthetic process IEA
 biological_processGO:0072350 tricarboxylic acid metabolic process IEA
 biological_processGO:1904182 regulation of pyruvate dehydrogenase activity IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0005759 mitochondrial matrix IEA
 molecular_functionGO:0003950 NAD+ ADP-ribosyltransferase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0034979 NAD-dependent protein deacetylase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047708 biotinidase activity IEA
 molecular_functionGO:0061690 lipoamidase activity IEA
 molecular_functionGO:0070403 NAD+ binding IEA


Pathways (from Reactome)
Pathway description
Transcriptional activation of mitochondrial biogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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