ENSGALG00000008957


Gallus gallus

Features
Gene ID: ENSGALG00000008957
  
Biological name :MSH6
  
Synonyms : MSH6 / mutS homolog 6
  
Possible biological names infered from orthology : DNA mismatch repair protein Msh6 / P52701 / P54276
  
Species: Gallus gallus
  
Chr. number: 3
Strand: 1
Band:
Gene start: 8773712
Gene end: 8784473
  
Corresponding Affymetrix probe sets: Gga.18251.1.S1_at (Chicken Array)   Gga.18251.1.S1_s_at (Chicken Array)   Gga.7477.1.S1_s_at (Chicken Array)   GgaAffx.22740.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000038835
Ensembl peptide - ENSGALP00000052100
NCBI entrez gene - 421291     See in Manteia.
RefSeq - XM_015278119
RefSeq - XM_015278118
swissprot - A0A1I7Q445
swissprot - A0A1D5PH24
Ensembl - ENSGALG00000008957
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 msh6ENSDARG00000104541Danio rerio
 MSH6ENSG00000116062Homo sapiens
 Msh6ENSMUSG00000005370Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000313  PWWP domain
 IPR000432  DNA mismatch repair protein MutS, C-terminal
 IPR007695  DNA mismatch repair protein MutS-like, N-terminal
 IPR007696  DNA mismatch repair protein MutS, core
 IPR007860  DNA mismatch repair protein MutS, connector domain
 IPR007861  DNA mismatch repair protein MutS, clamp
 IPR016151  DNA mismatch repair protein MutS, N-terminal
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006298 mismatch repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0008340 determination of adult lifespan IEA
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IEA
 biological_processGO:0009411 response to UV IEA
 biological_processGO:0016446 somatic hypermutation of immunoglobulin genes IEA
 biological_processGO:0016447 somatic recombination of immunoglobulin gene segments IEA
 biological_processGO:0045190 isotype switching IEA
 biological_processGO:0045830 positive regulation of isotype switching IEA
 biological_processGO:0045910 negative regulation of DNA recombination IEA
 biological_processGO:0051096 positive regulation of helicase activity IEA
 biological_processGO:0097193 intrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0032301 MutSalpha complex IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0000400 four-way junction DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003684 damaged DNA binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0030983 mismatched DNA binding IEA
 molecular_functionGO:0032137 guanine/thymine mispair binding IEA
 molecular_functionGO:0032142 single guanine insertion binding IEA
 molecular_functionGO:0032143 single thymine insertion binding IEA
 molecular_functionGO:0032357 oxidized purine DNA binding IEA
 molecular_functionGO:0032405 MutLalpha complex binding IEA
 molecular_functionGO:0035064 methylated histone binding IEA
 molecular_functionGO:0043531 ADP binding IEA


Pathways (from Reactome)
Pathway description
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000010748 EXO1 / exonuclease 1 / Q9QZ11* / Q9UQ84*  / reaction
 ENSGALG00000029292 PCNA / Q9DEA3 / Proliferating cell nuclear antigen / P17918* / P12004* / Pcna-ps2*  / reaction / complex
 ENSGALG00000008962 MSH2 / mutS homolog 2 / P43246* / P43247* / DNA mismatch repair protein Msh2 *  / complex / reaction
 ENSGALG00000039169 MLH1 / mutL homolog 1 / P40692* / Q9JK91* / DNA mismatch repair protein Mlh1 *  / complex / reaction






 

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