ENSGALG00000009565


Gallus gallus

Features
Gene ID: ENSGALG00000009565
  
Biological name :EIF2S1
  
Synonyms : EIF2S1 / Eukaryotic translation initiation factor 2 subunit 1 / Q5ZLX2
  
Possible biological names infered from orthology : eukaryotic translation initiation factor 2 subunit alpha / P05198 / Q6ZWX6
  
Species: Gallus gallus
  
Chr. number: 5
Strand: -1
Band:
Gene start: 28972911
Gene end: 28983409
  
Corresponding Affymetrix probe sets: GgaAffx.6007.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000015560
Ensembl peptide - ENSGALP00000047783
NCBI entrez gene - 423279     See in Manteia.
RefSeq - NM_001006477
RefSeq Peptide - NP_001006477
swissprot - Q5ZLX2
Ensembl - ENSGALG00000009565
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eif2s1aENSDARG00000005827Danio rerio
 eif2s1bENSDARG00000052178Danio rerio
 EIF2S1ENSG00000134001Homo sapiens
 Eif2s1ENSMUSG00000021116Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003029  S1 domain
 IPR011488  Translation initiation factor 2, alpha subunit
 IPR012340  Nucleic acid-binding, OB-fold
 IPR022967  RNA-binding domain, S1
 IPR024054  Translation initiation factor 2, alpha subunit, middle domain superfamily
 IPR024055  Translation initiation factor 2, alpha subunit, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006412 translation IEA
 biological_processGO:0006413 translational initiation IBA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0032057 negative regulation of translational initiation in response to stress IEA
 biological_processGO:0034198 cellular response to amino acid starvation IEA
 biological_processGO:0034644 cellular response to UV IEA
 biological_processGO:0034976 response to endoplasmic reticulum stress IEA
 biological_processGO:0043558 regulation of translational initiation in response to stress IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:1901216 positive regulation of neuron death IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005840 ribosome IBA
 cellular_componentGO:0005850 eukaryotic translation initiation factor 2 complex IEA
 cellular_componentGO:0005851 eukaryotic translation initiation factor 2B complex IEA
 cellular_componentGO:0010494 cytoplasmic stress granule IEA
 cellular_componentGO:0033290 eukaryotic 48S preinitiation complex IBA
 cellular_componentGO:0043614 multi-eIF complex IBA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003743 translation initiation factor activity IBA
 molecular_functionGO:0043022 ribosome binding IEA


Pathways (from Reactome)
Pathway description
PERK regulates gene expression
Translation initiation complex formation
Formation of the ternary complex, and subsequently, the 43S complex
Ribosomal scanning and start codon recognition
Recycling of eIF2:GDP


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000001313 EIF4H / eukaryotic translation initiation factor 4H / Q15056* / Q9WUK2*  / reaction
 ENSGALG00000008520 EIF4G1 / eukaryotic translation initiation factor 4 gamma 1 / Q04637* / Q6NZJ6*  / reaction
 ENSGALG00000042112 EIF4E / eukaryotic translation initiation factor 4E / P06730* / P63073*  / reaction
 ENSGALG00000033196 EIF2S2 / eukaryotic translation initiation factor 2 subunit beta / P20042* / Q99L45* / Eukaryotic translation initiation factor 2 subunit 2 *  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr