ENSGALG00000010847


Gallus gallus
regulationVEGFCfactorgrowthcellreceptorvegfendothelialproliferationactivitychemotaxisangiogenesisresponsemorphogenesissignalingvascularpdgfdomaincxcxcrepeatplatelet-derivedconservedsitecystine-knotcytokinehypoxiacell-matrixadhesionanimalorganembryonic

Features
Gene ID: ENSGALG00000010847
  
Biological name :VEGFC
  
Synonyms : vascular endothelial growth factor C / VEGFC
  
Possible biological names infered from orthology : P49767 / P97953
  
Species: Gallus gallus
  
Chr. number: 4
Strand: -1
Band:
Gene start: 44787058
Gene end: 44855135
  
Corresponding Affymetrix probe sets: Gga.12347.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000017608
NCBI entrez gene - 422573     See in Manteia.
RefSeq - XM_420532
swissprot - E1C7C6
Ensembl - ENSGALG00000010847
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vegfcENSDARG00000069640Danio rerio
 VEGFCENSG00000150630Homo sapiens
 VegfcENSMUSG00000031520Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
VEGFD / vascular endothelial growth factor D / O43915* / P97946*ENSGALG0000001655827


Protein motifs (from Interpro)
Interpro ID Name
 IPR000072  PDGF/VEGF domain
 IPR004153  CXCXC repeat
 IPR023581  Platelet-derived growth factor, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
anatomical structure developmentresponse to stressresponse to abiotic stimulusepithelial cell proliferationcell adhesioncell communicationregulation of molecular functioncellular response to stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processresponse to external stimulusresponse to chemicallocalization of cellmovement of cell or subcellular componentanatomical structure developmentresponse to stressresponse to abiotic stimulusepithelial cell proliferationcell adhesioncell communicationregulation of molecular functioncellular response to stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processresponse to external stimulusresponse to chemicallocalization of cellmovement of cell or subcellular componentanatomical structure developmentresponse to stressresponse to abiotic stimulusepithelial cell proliferationcell adhesioncell communicationregulation of molecular functioncellular response to stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processresponse to external stimulusresponse to chemicallocalization of cellmovement of cell or subcellular componentanatomical structure developmentresponse to stressresponse to abiotic stimulusepithelial cell proliferationcell adhesioncell communicationregulation of molecular functioncellular response to stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processresponse to external stimulusresponse to chemicallocalization of cellmovement of cell or subcellular componentanatomical structure developmentresponse to stressresponse to abiotic stimulusepithelial cell proliferationcell adhesioncell communicationregulation of molecular functioncellular response to stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processresponse to external stimulusresponse to chemicallocalization of cellmovement of cell or subcellular componentanatomical structure developmentresponse to stressresponse to abiotic stimulusepithelial cell proliferationcell adhesioncell communicationregulation of molecular functioncellular response to stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processresponse to external stimulusresponse to chemicallocalization of cellmovement of cell or subcellular componentanatomical structure developmentresponse to stressresponse to abiotic stimulusepithelial cell proliferationcell adhesioncell communicationregulation of molecular functioncellular response to stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processresponse to external stimulusresponse to chemicallocalization of cellmovement of cell or subcellular componentanatomical structure developmentresponse to stressresponse to abiotic stimulusepithelial cell proliferationcell adhesioncell communicationregulation of molecular functioncellular response to stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processresponse to external stimulusresponse to chemicallocalization of cellmovement of cell or subcellular componentanatomical structure developmentresponse to stressresponse to abiotic stimulusepithelial cell proliferationcell adhesioncell communicationregulation of molecular functioncellular response to stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processresponse to external stimulusresponse to chemicallocalization of cellmovement of cell or subcellular componentanatomical structure developmentresponse to stressresponse to abiotic stimulusepithelial cell proliferationcell adhesioncell communicationregulation of molecular functioncellular response to stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processresponse to external stimulusresponse to chemicallocalization of cellmovement of cell or subcellular componentanatomicanatomical structure developmentresponseresponse to stressresponseresponse to abiotic stimulusepitheliepithelial cell proliferationcell adhcell adhesioncell comcell communicationregulatiregulation of molecular functioncellularcellular response to stimulusnitrogennitrogen compound metabolic processcellularcellular metabolic processprimary primary metabolic processorganic organic substance metabolic processresponseresponse to external stimulusresponseresponse to chemicallocalizalocalization of cellmovementmovement of cell or subcellular component
protein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingprotein bindingreceptor regulator activityreceptor regulator activity
extracellular regionmembraneextracellular regionmembraneextracellular regionmembraneextracellular regionmembraneextracellular regionmembraneextracellular regionmembraneextracellular regionmembraneextracellular regionmembraneextracellular regionmembraneextracellular regionmembraneextracellular regionextracellular regionmembranemembrane
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IBA
 biological_processGO:0001666 response to hypoxia IBA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IBA
 biological_processGO:0001954 positive regulation of cell-matrix adhesion IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0009887 animal organ morphogenesis IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0016331 morphogenesis of embryonic epithelium IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0050918 positive chemotaxis IEA
 biological_processGO:0050930 induction of positive chemotaxis IEA
 biological_processGO:0060754 positive regulation of mast cell chemotaxis IEA
 biological_processGO:1901492 positive regulation of lymphangiogenesis IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0008083 growth factor activity IBA
 molecular_functionGO:0042056 chemoattractant activity IEA
 molecular_functionGO:0043185 vascular endothelial growth factor receptor 3 binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
VEGF ligand-receptor interactions
VEGF binds to VEGFR leading to receptor dimerization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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