ENSGALG00000011058


Gallus gallus
regulationLEPRreceptorleptinprocessactivityovarianfollicleproteinenergymetaboliccholesterolgeneexpressionsignalingpathwaycellappetitehomeostasisfattyacidbonelonghematopoietingpfamilyconservedsitefibronectintypeiii

Features
Gene ID: ENSGALG00000011058
  
Biological name :LEPR
  
Synonyms : LEPR / leptin receptor precursor
  
Possible biological names infered from orthology : leptin receptor / P48356 / P48357
  
Species: Gallus gallus
  
Chr. number: 8
Strand: 1
Band:
Gene start: 28434800
Gene end: 28465001
  
Corresponding Affymetrix probe sets: Gga.13.1.S1_s_at (Chicken Array)   Gga.13.2.S1_s_at (Chicken Array)   Gga.9238.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000045189
Ensembl peptide - ENSGALP00000032296
NCBI entrez gene - 374223     See in Manteia.
RefSeq - NM_204323
RefSeq Peptide - NP_989654
swissprot - F1NDH9
swissprot - A0A1D5NXT9
Ensembl - ENSGALG00000011058
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 leprENSDARG00000070961Danio rerio
 LEPRENSG00000116678Homo sapiens
 LeprENSMUSG00000057722Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003529  Long hematopoietin receptor, Gp130 family 2, conserved site
 IPR003961  Fibronectin type III
 IPR010457  Immunoglobulin C2-set-like, ligand-binding
 IPR013783  Immunoglobulin-like fold
 IPR015752  Leptin receptor


Gene Ontology (GO)
anatomical structure developmentnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processoxidation-reduction processestablishment of localizationsmall molecule metabolic processcatabolic processprocess utilizing autophagic mechanismmacromolecule localizationregulation of biological qualitycell communicationresponse to chemicalcellular response to stimuluscellular developmental processcell activationresponse to external stimulusresponse to endogenous stimulusbiosynthetic processtissue remodelingregulation of molecular functionfeeding behaviordevelopmental growthanatomical structure developmentnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processoxidation-reduction processestablishment of localizationsmall molecule metabolic processcatabolic processprocess utilizing autophagic mechanismmacromolecule localizationregulation of biological qualitycell communicationresponse to chemicalcellular response to stimuluscellular developmental processcell activationresponse to external stimulusresponse to endogenous stimulusbiosynthetic processtissue remodelingregulation of molecular functionfeeding behaviordevelopmental growthanatomical structure developmentnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processoxidation-reduction processestablishment of localizationsmall molecule metabolic processcatabolic processprocess utilizing autophagic mechanismmacromolecule localizationregulation of biological qualitycell communicationresponse to chemicalcellular response to stimuluscellular developmental processcell activationresponse to external stimulusresponse to endogenous stimulusbiosynthetic processtissue remodelingregulation of molecular functionfeeding behaviordevelopmental growthanatomical structure developmentnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processoxidation-reduction processestablishment of localizationsmall molecule metabolic processcatabolic processprocess utilizing autophagic mechanismmacromolecule localizationregulation of biological qualitycell communicationresponse to chemicalcellular response to stimuluscellular developmental processcell activationresponse to external stimulusresponse to endogenous stimulusbiosynthetic processtissue remodelingregulation of molecular functionfeeding behaviordevelopmental growthanatomical structure developmentnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processoxidation-reduction processestablishment of localizationsmall molecule metabolic processcatabolic processprocess utilizing autophagic mechanismmacromolecule localizationregulation of biological qualitycell communicationresponse to chemicalcellular response to stimuluscellular developmental processcell activationresponse to external stimulusresponse to endogenous stimulusbiosynthetic processtissue remodelingregulation of molecular functionfeeding behaviordevelopmental growthanatomical structure developmentnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processoxidation-reduction processestablishment of localizationsmall molecule metabolic processcatabolic processprocess utilizing autophagic mechanismmacromolecule localizationregulation of biological qualitycell communicationresponse to chemicalcellular response to stimuluscellular developmental processcell activationresponse to external stimulusresponse to endogenous stimulusbiosynthetic processtissue remodelingregulation of molecular functionfeeding behaviordevelopmental growthanatomical structure developmentnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processoxidation-reduction processestablishment of localizationsmall molecule metabolic processcatabolic processprocess utilizing autophagic mechanismmacromolecule localizationregulation of biological qualitycell communicationresponse to chemicalcellular response to stimuluscellular developmental processcell activationresponse to external stimulusresponse to endogenous stimulusbiosynthetic processtissue remodelingregulation of molecular functionfeeding behaviordevelopmental growthanatomical structure developmentnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processoxidation-reduction processestablishment of localizationsmall molecule metabolic processcatabolic processprocess utilizing autophagic mechanismmacromolecule localizationregulation of biological qualitycell communicationresponse to chemicalcellular response to stimuluscellular developmental processcell activationresponse to external stimulusresponse to endogenous stimulusbiosynthetic processtissue remodelingregulation of molecular functionfeeding behaviordevelopmental growthanatomical structure developmentnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processoxidation-reduction processestablishment of localizationsmall molecule metabolic processcatabolic processprocess utilizing autophagic mechanismmacromolecule localizationregulation of biological qualitycell communicationresponse to chemicalcellular response to stimuluscellular developmental processcell activationresponse to external stimulusresponse to endogenous stimulusbiosynthetic processtissue remodelingregulation of molecular functionfeeding behaviordevelopmental growthanatomical structure developmentnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processoxidation-reduction processestablishment of localizationsmall molecule metabolic processcatabolic processprocess utilizing autophagic mechanismmacromolecule localizationregulation of biological qualitycell communicationresponse to chemicalcellular response to stimuluscellular developmental processcell activationresponse to external stimulusresponse to endogenous stimulusbiosynthetic processtissue remodelingregulation of molecular functionfeeding behaviordevelopmental growthanatoanatomical structure developmentnitronitrogen compound metabolic processcellucellular metabolic processprimaprimary metabolic processorganorganic substance metabolic processoxidaoxidation-reduction processestabestablishment of localizationsmallsmall molecule metabolic processcatabcatabolic processproceprocess utilizing autophagic mechanismmacromacromolecule localizationregulregulation of biological qualitycell cell communicationresporesponse to chemicalcellucellular response to stimuluscellucellular developmental processcell cell activationresporesponse to external stimulusresporesponse to endogenous stimulusbiosybiosynthetic processtissutissue remodelingregulregulation of molecular functionfeedifeeding behaviordeveldevelopmental growth
signaling receptor activityprotein bindingsignaling receptor activityprotein bindingsignaling receptor activityprotein bindingsignaling receptor activityprotein bindingsignaling receptor activityprotein bindingsignaling receptor activityprotein bindingsignaling receptor activityprotein bindingsignaling receptor activityprotein bindingsignaling receptor activityprotein bindingsignaling receptor activityprotein bindingsignaling receptor activitysignaling receptor activityprotein bindingprotein binding
cellmembraneprotein-containing complexcellmembraneprotein-containing complexcellmembraneprotein-containing complexcellmembraneprotein-containing complexcellmembraneprotein-containing complexcellmembraneprotein-containing complexcellmembraneprotein-containing complexcellmembraneprotein-containing complexcellmembraneprotein-containing complexcellmembraneprotein-containing complexcellcellmembranemembraneprotein-containing complexprotein-containing complex
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001552 ovarian follicle atresia IMP
 biological_processGO:0001934 positive regulation of protein phosphorylation IMP
 biological_processGO:0006112 energy reserve metabolic process IMP
 biological_processGO:0006909 phagocytosis IEA
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0010507 negative regulation of autophagy IEA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0010887 negative regulation of cholesterol storage IMP
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0019953 sexual reproduction IEA
 biological_processGO:0030217 T cell differentiation IEA
 biological_processGO:0032099 negative regulation of appetite IMP
 biological_processGO:0032100 positive regulation of appetite IMP
 biological_processGO:0033210 leptin-mediated signaling pathway IEA
 biological_processGO:0042593 glucose homeostasis IEA
 biological_processGO:0044321 response to leptin IEA
 biological_processGO:0045717 negative regulation of fatty acid biosynthetic process IMP
 biological_processGO:0045721 negative regulation of gluconeogenesis IEA
 biological_processGO:0046321 positive regulation of fatty acid oxidation IMP
 biological_processGO:0046850 regulation of bone remodeling IEA
 biological_processGO:0051346 negative regulation of hydrolase activity IEA
 biological_processGO:0060259 regulation of feeding behavior IEA
 biological_processGO:0097009 energy homeostasis IEA
 biological_processGO:0098868 bone growth IEA
 biological_processGO:2000355 negative regulation of ovarian follicle development IMP
 cellular_componentGO:0005623 cell IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0043235 receptor complex IEA
 molecular_functionGO:0004896 cytokine receptor activity IEA
 molecular_functionGO:0038021 leptin receptor activity IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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