ENSGALG00000011104


Gallus gallus

Features
Gene ID: ENSGALG00000011104
  
Biological name :GCG
  
Synonyms : GCG / Glucagon Glicentin-related polypeptide Glucagon Glucagon-like peptide 1 Glucagon-like peptide 1(7-37) Glucagon-like peptide 1(7-36) Glucagon-like peptide 2 / P68259
  
Possible biological names infered from orthology : glucagon / Glucagon Glicentin Glicentin-related polypeptide Oxyntomodulin Glucagon Glucagon-like peptide 1 Glucagon-like peptide 1(7-37) Glucagon-like peptide 1(7-36) Glucagon-like peptide 2 / P01275 / P55095
  
Species: Gallus gallus
  
Chr. number: 7
Strand: 1
Band:
Gene start: 21233409
Gene end: 21245324
  
Corresponding Affymetrix probe sets: GgaAffx.21780.1.S1_s_at (Chicken Array)   GgaAffx.21780.2.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000032494
Ensembl peptide - ENSGALP00000059361
Ensembl peptide - ENSGALP00000060788
NCBI entrez gene - 396196     See in Manteia.
RefSeq - XM_015289640
RefSeq - NM_001190165
RefSeq - NM_205260
RefSeq - XM_015289638
RefSeq - XM_015289639
RefSeq Peptide - NP_001177094
RefSeq Peptide - NP_990591
swissprot - Q3HWX0
swissprot - Q3HWX1
swissprot - P68259
Ensembl - ENSGALG00000011104
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gcgaENSDARG00000079296Danio rerio
 gcgbENSDARG00000040907Danio rerio
 GCGENSG00000115263Homo sapiens
 GcgENSMUSG00000000394Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ENSGALG0000004283717


Protein motifs (from Interpro)
Interpro ID Name
 IPR000532  Glucagon/GIP/secretin/VIP
 IPR015550  Glucagon


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IBA
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010737 protein kinase A signaling IBA
 biological_processGO:0010800 positive regulation of peptidyl-threonine phosphorylation IEA
 biological_processGO:0032092 positive regulation of protein binding IEA
 biological_processGO:0032099 negative regulation of appetite IDA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus IBA
 biological_processGO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter IEA
 biological_processGO:0042594 response to starvation IBA
 biological_processGO:0043066 negative regulation of apoptotic process IBA
 biological_processGO:0045860 positive regulation of protein kinase activity IEA
 biological_processGO:0050796 regulation of insulin secretion IEA
 biological_processGO:0051571 positive regulation of histone H3-K4 methylation IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0090280 positive regulation of calcium ion import IEA
 biological_processGO:1900118 negative regulation of execution phase of apoptosis IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0005179 hormone activity IBA
 molecular_functionGO:0031769 glucagon receptor binding IBA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Glucagon signaling in metabolic regulation
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
G alpha (q) signalling events
G alpha (s) signalling events
Glucagon-type ligand receptors
Synthesis, secretion, and deacylation of Ghrelin


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000011219 GCGR / glucagon receptor / P47871* / Q61606*  / complex / reaction
 ENSGALG00000041800 GLP2R / glucagon like peptide 2 receptor / O95838* / Q5IXF8*  / complex / reaction
 ENSGALG00000042452 DPP4 / dipeptidyl peptidase 4 / P27487* / P28843* / Dipeptidyl peptidase 4 Dipeptidyl peptidase 4 membrane form Dipeptidyl peptidase 4 soluble form*  / reaction






 

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