ENSGALG00000012200


Gallus gallus

Features
Gene ID: ENSGALG00000012200
  
Biological name :GCH1
  
Synonyms : GCH1 / GTP cyclohydrolase 1
  
Possible biological names infered from orthology : P30793 / Q05915
  
Species: Gallus gallus
  
Chr. number: 5
Strand: 1
Band:
Gene start: 56470545
Gene end: 56487623
  
Corresponding Affymetrix probe sets: Gga.674.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000053037
Ensembl peptide - ENSGALP00000019895
NCBI entrez gene - 396146     See in Manteia.
RefSeq - NM_205223
RefSeq Peptide - NP_990554
swissprot - F1NEK8
swissprot - A0A1D5PJP1
Ensembl - ENSGALG00000012200
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CU464134.2ENSDARG00000113158Danio rerio
 gch1ENSDARG00000070453Danio rerio
 GCH1ENSG00000131979Homo sapiens
 Gch1ENSMUSG00000037580Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001474  GTP cyclohydrolase I
 IPR018234  GTP cyclohydrolase I, conserved site
 IPR020602  GTP cyclohydrolase I domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006729 tetrahydrobiopterin biosynthetic process IEA
 biological_processGO:0008217 regulation of blood pressure IEA
 biological_processGO:0010460 positive regulation of heart rate IEA
 biological_processGO:0014916 regulation of lung blood pressure IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0034341 response to interferon-gamma IEA
 biological_processGO:0034612 response to tumor necrosis factor IEA
 biological_processGO:0042416 dopamine biosynthetic process IEA
 biological_processGO:0042559 pteridine-containing compound biosynthetic process IEA
 biological_processGO:0046654 tetrahydrofolate biosynthetic process IEA
 biological_processGO:0050884 neuromuscular process controlling posture IEA
 biological_processGO:0051000 positive regulation of nitric-oxide synthase activity IEA
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:2000121 regulation of removal of superoxide radicals IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0003934 GTP cyclohydrolase I activity IEA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0051019 mitogen-activated protein kinase binding IEA


Pathways (from Reactome)
Pathway description
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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