ENSGALG00000013892


Gallus gallus

Features
Gene ID: ENSGALG00000013892
  
Biological name :MAP3K5
  
Synonyms : MAP3K5 / mitogen-activated protein kinase kinase kinase 5
  
Possible biological names infered from orthology : O35099 / Q99683
  
Species: Gallus gallus
  
Chr. number: 3
Strand: 1
Band:
Gene start: 55132631
Gene end: 55230515
  
Corresponding Affymetrix probe sets: Gga.19808.1.S1_at (Chicken Array)   GgaAffx.24305.1.S1_at (Chicken Array)   GgaAffx.8822.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000022482
Ensembl peptide - ENSGALP00000056246
NCBI entrez gene - 421688     See in Manteia.
RefSeq - XM_015284184
swissprot - A0A1D5PTJ8
swissprot - F1NYS9
Ensembl - ENSGALG00000013892
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 map3k5ENSDARG00000005416Danio rerio
 MAP3K5ENSG00000197442Homo sapiens
 Map3k5ENSMUSG00000071369Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MAP3K15 / mitogen-activated protein kinase kinase kinase 15 / A2AQW0* / Q6ZN16*ENSGALG0000001642658
ENSGALG0000003070616


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR025136  Domain of unknown function DUF4071


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0000186 activation of MAPKK activity IBA
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007254 JNK cascade IEA
 biological_processGO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress IEA
 biological_processGO:0010941 regulation of cell death IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0034198 cellular response to amino acid starvation IEA
 biological_processGO:0034976 response to endoplasmic reticulum stress IEA
 biological_processGO:0038066 p38MAPK cascade IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0043507 positive regulation of JUN kinase activity IEA
 biological_processGO:0045663 positive regulation of myoblast differentiation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0046330 positive regulation of JNK cascade IEA
 biological_processGO:0051403 stress-activated MAPK cascade IEA
 biological_processGO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IEA
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:0097300 programmed necrotic cell death IEA
 biological_processGO:1901216 positive regulation of neuron death IEA
 biological_processGO:1902170 cellular response to reactive nitrogen species IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:1902911 protein kinase complex IEA
 cellular_componentGO:1990604 IRE1-TRAF2-ASK1 complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004709 MAP kinase kinase kinase activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0019903 protein phosphatase binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000004370 MAP2K6 / mitogen-activated protein kinase kinase 6 / P52564* / P70236*  / reaction
 ENSGALG00000041285 MAP2K3 / mitogen-activated protein kinase kinase 3 / O09110* / P46734*  / reaction
 ENSGALG00000015704 TXN / P08629 / Thioredoxin / Txn1* / TXNDC2* / P10599* / P10639* / Q86VQ3* / thioredoxin 1* / thioredoxin domain containing 2* / thioredoxin domain containing 2 (spermatozoa)*  / complex






 

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