ENSGALG00000014365


Gallus gallus
regulationRBPJcelltranscriptionbindingrnapolymeraseiidifferentiationfactordnamorphogenesisdevelopmentsignalingfatepromoterpathwayproliferationsequence-specificbloodvesselresponseinvolvednotchcommitmentactivitydomaindna-bindingheartspecificationcardiac

Features
Gene ID: ENSGALG00000014365
  
Biological name :RBPJ
  
Synonyms : RBPJ / recombination signal binding protein for immunoglobulin kappa J region
  
Possible biological names infered from orthology : P31266 / Q06330 / Recombining binding protein suppressor of hairless
  
Species: Gallus gallus
  
Chr. number: 4
Strand: -1
Band:
Gene start: 73717884
Gene end: 73740235
  
Corresponding Affymetrix probe sets: Gga.10176.1.S1_at (Chicken Array)   Gga.10176.1.S1_s_at (Chicken Array)   GgaAffx.24402.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000053948
Ensembl peptide - ENSGALP00000023161
NCBI entrez gene - 422802     See in Manteia.
RefSeq - XM_420752
RefSeq - XM_015285709
RefSeq - XM_015285710
RefSeq - XM_004936138
RefSeq - XM_015285708
swissprot - F1NIJ8
swissprot - A0A1D5PM75
Ensembl - ENSGALG00000014365
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rbpjaENSDARG00000003398Danio rerio
 rbpjbENSDARG00000052091Danio rerio
 RBPJENSG00000168214Homo sapiens
 RbpjENSMUSG00000039191Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RBPJL / recombination signal binding protein for immunoglobulin kappa J region like / O08674* / Q9UBG7*ENSGALG0000000395251


Protein motifs (from Interpro)
Interpro ID Name
 IPR002909  IPT domain
 IPR008967  p53-like transcription factor, DNA-binding
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR015350  Beta-trefoil DNA-binding domain
 IPR015351  RBP-J/Cbf11/Cbf12, DNA binding


Gene Ontology (GO)
nitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcellular developmental processtissue remodelingresponse to stressimmune responsecell communicationcellular response to stimuluscell activationossificationresponse to endogenous stimulusresponse to chemicalmaintenance of cell numberresponse to external stimulusresponse to biotic stimulusmolting cycledevelopmental maturationmuscle cell proliferationdevelopmental growthresponse to abiotic stimulusmacromolecule localizationestablishment of localizationcytokine productionnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcellular developmental processtissue remodelingresponse to stressimmune responsecell communicationcellular response to stimuluscell activationossificationresponse to endogenous stimulusresponse to chemicalmaintenance of cell numberresponse to external stimulusresponse to biotic stimulusmolting cycledevelopmental maturationmuscle cell proliferationdevelopmental growthresponse to abiotic stimulusmacromolecule localizationestablishment of localizationcytokine productionnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcellular developmental processtissue remodelingresponse to stressimmune responsecell communicationcellular response to stimuluscell activationossificationresponse to endogenous stimulusresponse to chemicalmaintenance of cell numberresponse to external stimulusresponse to biotic stimulusmolting cycledevelopmental maturationmuscle cell proliferationdevelopmental growthresponse to abiotic stimulusmacromolecule localizationestablishment of localizationcytokine productionnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcellular developmental processtissue remodelingresponse to stressimmune responsecell communicationcellular response to stimuluscell activationossificationresponse to endogenous stimulusresponse to chemicalmaintenance of cell numberresponse to external stimulusresponse to biotic stimulusmolting cycledevelopmental maturationmuscle cell proliferationdevelopmental growthresponse to abiotic stimulusmacromolecule localizationestablishment of localizationcytokine productionnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcellular developmental processtissue remodelingresponse to stressimmune responsecell communicationcellular response to stimuluscell activationossificationresponse to endogenous stimulusresponse to chemicalmaintenance of cell numberresponse to external stimulusresponse to biotic stimulusmolting cycledevelopmental maturationmuscle cell proliferationdevelopmental growthresponse to abiotic stimulusmacromolecule localizationestablishment of localizationcytokine productionnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcellular developmental processtissue remodelingresponse to stressimmune responsecell communicationcellular response to stimuluscell activationossificationresponse to endogenous stimulusresponse to chemicalmaintenance of cell numberresponse to external stimulusresponse to biotic stimulusmolting cycledevelopmental maturationmuscle cell proliferationdevelopmental growthresponse to abiotic stimulusmacromolecule localizationestablishment of localizationcytokine productionnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcellular developmental processtissue remodelingresponse to stressimmune responsecell communicationcellular response to stimuluscell activationossificationresponse to endogenous stimulusresponse to chemicalmaintenance of cell numberresponse to external stimulusresponse to biotic stimulusmolting cycledevelopmental maturationmuscle cell proliferationdevelopmental growthresponse to abiotic stimulusmacromolecule localizationestablishment of localizationcytokine productionnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcellular developmental processtissue remodelingresponse to stressimmune responsecell communicationcellular response to stimuluscell activationossificationresponse to endogenous stimulusresponse to chemicalmaintenance of cell numberresponse to external stimulusresponse to biotic stimulusmolting cycledevelopmental maturationmuscle cell proliferationdevelopmental growthresponse to abiotic stimulusmacromolecule localizationestablishment of localizationcytokine productionnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcellular developmental processtissue remodelingresponse to stressimmune responsecell communicationcellular response to stimuluscell activationossificationresponse to endogenous stimulusresponse to chemicalmaintenance of cell numberresponse to external stimulusresponse to biotic stimulusmolting cycledevelopmental maturationmuscle cell proliferationdevelopmental growthresponse to abiotic stimulusmacromolecule localizationestablishment of localizationcytokine productionnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcellular developmental processtissue remodelingresponse to stressimmune responsecell communicationcellular response to stimuluscell activationossificationresponse to endogenous stimulusresponse to chemicalmaintenance of cell numberresponse to external stimulusresponse to biotic stimulusmolting cycledevelopmental maturationmuscle cell proliferationdevelopmental growthresponse to abiotic stimulusmacromolecule localizationestablishment of localizationcytokine productionnitronitrogen compound metabolic processbiosybiosynthetic processcellucellular metabolic processprimaprimary metabolic processorganorganic substance metabolic processanatoanatomical structure developmentcellucellular developmental processtissutissue remodelingresporesponse to stressimmunimmune responsecell cell communicationcellucellular response to stimuluscell cell activationossifossificationresporesponse to endogenous stimulusresporesponse to chemicalmaintmaintenance of cell numberresporesponse to external stimulusresporesponse to biotic stimulusmoltimolting cycledeveldevelopmental maturationmusclmuscle cell proliferationdeveldevelopmental growthresporesponse to abiotic stimulusmacromacromolecule localizationestabestablishment of localizationcytokcytokine production
organic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityprotein bindingchromatin bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityprotein bindingchromatin bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityprotein bindingchromatin bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityprotein bindingchromatin bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityprotein bindingchromatin bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityprotein bindingchromatin bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityprotein bindingchromatin bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityprotein bindingchromatin bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityprotein bindingchromatin bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityprotein bindingchromatin bindingorganic cyclic compound bindorganic cyclic compound bindingheterocyclic compound bindinheterocyclic compound bindingDNA-binding transcription faDNA-binding transcription factor activityprotein bindingprotein bindingchromatin bindingchromatin binding
protein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexprotein-containing complexcellcellorganelleorganellemembrane-enclosed lumenmembrane-enclosed lumen
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001756 somitogenesis IEA
 biological_processGO:0001837 epithelial to mesenchymal transition IEA
 biological_processGO:0001974 blood vessel remodeling IEA
 biological_processGO:0002437 inflammatory response to antigenic stimulus IEA
 biological_processGO:0003139 secondary heart field specification IEA
 biological_processGO:0003151 outflow tract morphogenesis IEA
 biological_processGO:0003157 endocardium development IEA
 biological_processGO:0003160 endocardium morphogenesis IEA
 biological_processGO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation IEA
 biological_processGO:0003214 cardiac left ventricle morphogenesis IEA
 biological_processGO:0003222 ventricular trabecula myocardium morphogenesis IEA
 biological_processGO:0003256 regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006959 humoral immune response IEA
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0007221 positive regulation of transcription of Notch receptor target IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0009912 auditory receptor cell fate commitment IEA
 biological_processGO:0009957 epidermal cell fate specification IEA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0021983 pituitary gland development IEA
 biological_processGO:0030097 hemopoiesis IEA
 biological_processGO:0030182 neuron differentiation IEA
 biological_processGO:0030183 B cell differentiation IEA
 biological_processGO:0030216 keratinocyte differentiation IEA
 biological_processGO:0030279 negative regulation of ossification IEA
 biological_processGO:0030513 positive regulation of BMP signaling pathway IEA
 biological_processGO:0035019 somatic stem cell population maintenance IEA
 biological_processGO:0035912 dorsal aorta morphogenesis IEA
 biological_processGO:0036302 atrioventricular canal development IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0042742 defense response to bacterium IEA
 biological_processGO:0043011 myeloid dendritic cell differentiation IEA
 biological_processGO:0045165 cell fate commitment IEA
 biological_processGO:0045596 negative regulation of cell differentiation IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048505 regulation of timing of cell differentiation IEA
 biological_processGO:0048733 sebaceous gland development IEA
 biological_processGO:0048820 hair follicle maturation IEA
 biological_processGO:0048844 artery morphogenesis IEA
 biological_processGO:0060045 positive regulation of cardiac muscle cell proliferation IEA
 biological_processGO:0060486 Clara cell differentiation IEA
 biological_processGO:0060716 labyrinthine layer blood vessel development IEA
 biological_processGO:0060844 arterial endothelial cell fate commitment IEA
 biological_processGO:0061419 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia IEA
 biological_processGO:0072554 blood vessel lumenization IEA
 biological_processGO:0072602 interleukin-4 secretion IEA
 biological_processGO:0097101 blood vessel endothelial cell fate specification IEA
 biological_processGO:1901186 positive regulation of ERBB signaling pathway IEA
 biological_processGO:1901189 positive regulation of ephrin receptor signaling pathway IEA
 biological_processGO:1901297 positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment IEA
 biological_processGO:2000138 positive regulation of cell proliferation involved in heart morphogenesis IEA
 cellular_componentGO:0002193 MAML1-RBP-Jkappa- ICN1 complex IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0017053 transcriptional repressor complex IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000982 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001103 RNA polymerase II repressing transcription factor binding IEA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0047485 protein N-terminus binding IEA
 molecular_functionGO:0070491 repressing transcription factor binding IEA


Pathways (from Reactome)
Pathway description
NOTCH2 intracellular domain regulates transcription
RUNX3 regulates NOTCH signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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