ENSGALG00000017148


Gallus gallus
proteinCENPJcentrioleassemblycentrosomemitoticbindingciliumregulationbodyt-complexdomainreplicationpathwaymicrotubuleduplicationcellnon-motileplasmamembranebasallosscentrosomesrecruitmentproteinsc-terminalfamilycentromerejsmoothenedsignaling

Features
Gene ID: ENSGALG00000017148
  
Biological name :CENPJ
  
Synonyms : CENPJ / centromere protein J
  
Possible biological names infered from orthology : Q569L8 / Q9HC77
  
Species: Gallus gallus
  
Chr. number: 1
Strand: 1
Band:
Gene start: 179310484
Gene end: 179327166
  
Corresponding Affymetrix probe sets: GgaAffx.10985.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000027640
NCBI entrez gene - 418960     See in Manteia.
RefSeq - XM_417152
swissprot - E1C0R8
Ensembl - ENSGALG00000017148
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cenpjENSDARG00000018121Danio rerio
 CENPJENSG00000151849Homo sapiens
 CenpjENSMUSG00000064128Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tcp10a* / Tcp10b* / Tcp10c* / t-complex protein 10c* / t-complex protein 10a* / t-complex protein 10b*ENSGALG0000004388210


Protein motifs (from Interpro)
Interpro ID Name
 IPR009852  T-complex protein 10, C-terminal domain
 IPR026581  T-complex protein 10 family
 IPR033068  Centromere protein J


Gene Ontology (GO)
cellular component organizationcellular component biogenesiscell cyclemicrotubule-based processcell communicationcellular response to stimuluscell divisioncellular component organizationcellular component biogenesiscell cyclemicrotubule-based processcell communicationcellular response to stimuluscell divisioncellular component organizationcellular component biogenesiscell cyclemicrotubule-based processcell communicationcellular response to stimuluscell divisioncellular component organizationcellular component biogenesiscell cyclemicrotubule-based processcell communicationcellular response to stimuluscell divisioncellular component organizationcellular component biogenesiscell cyclemicrotubule-based processcell communicationcellular response to stimuluscell divisioncellular component organizationcellular component biogenesiscell cyclemicrotubule-based processcell communicationcellular response to stimuluscell divisioncellular component organizationcellular component biogenesiscell cyclemicrotubule-based processcell communicationcellular response to stimuluscell divisioncellular component organizationcellular component biogenesiscell cyclemicrotubule-based processcell communicationcellular response to stimuluscell divisioncellular component organizationcellular component biogenesiscell cyclemicrotubule-based processcell communicationcellular response to stimuluscell divisioncellular component organizationcellular component biogenesiscell cyclemicrotubule-based processcell communicationcellular response to stimuluscell divisioncellular component ocellular component organizationcellular component bcellular component biogenesiscell cyclecell cyclemicrotubule-based prmicrotubule-based processcell communicationcell communicationcellular response tocellular response to stimuluscell divisioncell division
protein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein binding
cellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellcellorganelleorganellemembrane-enclosed lumenmembrane-enclosed lumenmembranemembrane
TypeGO IDTermEv.Code
 biological_processGO:0007099 centriole replication IEA
 biological_processGO:0007224 smoothened signaling pathway IEA
 biological_processGO:0044458 motile cilium assembly IEA
 biological_processGO:0046599 regulation of centriole replication IEA
 biological_processGO:0046785 microtubule polymerization IEA
 biological_processGO:0051298 centrosome duplication IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0061511 centriole elongation IEA
 biological_processGO:0098534 centriole assembly IEA
 biological_processGO:1902857 positive regulation of non-motile cilium assembly IEA
 biological_processGO:1903087 mitotic spindle pole body duplication IEA
 biological_processGO:1905515 non-motile cilium assembly IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005814 centriole IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0036064 ciliary basal body IEA
 molecular_functionGO:0015631 tubulin binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
AURKA Activation by TPX2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000014725 PLK2 / polo like kinase 2 / P53351* / Q9NYY3* / Serine/threonine-protein kinase PLK2 *  / reaction






 

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