ENSGALG00000039895


Gallus gallus

Features
Gene ID: ENSGALG00000039895
  
Biological name :EPHA2
  
Synonyms : EPHA2 / EPH receptor A2
  
Possible biological names infered from orthology : P29317
  
Species: Gallus gallus
  
Chr. number: 21
Strand: -1
Band:
Gene start: 4315016
Gene end: 4323502
  
Corresponding Affymetrix probe sets: Gga.940.1.A1_at (Chicken Array)   Gga.940.1.S1_at (Chicken Array)   GgaAffx.2327.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000057639
NCBI entrez gene - 771550     See in Manteia.
RefSeq - XM_001234813
swissprot - A0A1D5PXE5
Ensembl - ENSGALG00000039895
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 EPHA2ENSG00000142627Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EPHA1 / ephrin type-A receptor 1 precursor ENSGALG0000001468747
EPHA10* / Q5JZY3* / Q8BYG9* / EPH receptor A10* / Ephrin type-A receptor 10 *ENSGALG0000000191222
ENSGALG0000004094914
EPHA10* / Q5JZY3* / Q8BYG9* / EPH receptor A10* / Ephrin type-A receptor 10 *ENSGALG0000004414914


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001090  Ephrin receptor ligand binding domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001426  Tyrosine-protein kinase, receptor class V, conserved site
 IPR001660  Sterile alpha motif domain
 IPR003961  Fibronectin type III
 IPR008266  Tyrosine-protein kinase, active site
 IPR008979  Galactose-binding-like domain superfamily
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011009  Protein kinase-like domain superfamily
 IPR011641  Tyrosine-protein kinase ephrin type A/B receptor-like
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR016257  Ephrin receptor type-A /type-B
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR027936  Ephrin receptor, transmembrane domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IEA
 biological_processGO:0010591 regulation of lamellipodium assembly IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0030216 keratinocyte differentiation IEA
 biological_processGO:0033628 regulation of cell adhesion mediated by integrin IEA
 biological_processGO:0043491 protein kinase B signaling IEA
 biological_processGO:0046058 cAMP metabolic process IEA
 biological_processGO:0048013 ephrin receptor signaling pathway IEA
 biological_processGO:0048870 cell motility IEA
 biological_processGO:0051898 negative regulation of protein kinase B signaling IEA
 biological_processGO:0060326 cell chemotaxis IEA
 biological_processGO:0070372 regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070848 response to growth factor IEA
 biological_processGO:0090630 activation of GTPase activity IEA
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0031256 leading edge membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005003 ephrin receptor activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0045296 cadherin binding IEA


Pathways (from Reactome)
Pathway description
EPH-Ephrin signaling
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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