ENSGALG00000040909


Gallus gallus

Features
Gene ID: ENSGALG00000040909
  
Biological name :WRN
  
Synonyms : Werner syndrome RecQ like helicase / WRN
  
Possible biological names infered from orthology : O09053 / Q14191
  
Species: Gallus gallus
  
Chr. number: 4
Strand: 1
Band:
Gene start: 34931711
Gene end: 34972810
  
Corresponding Affymetrix probe sets: Gga.18462.1.S1_at (Chicken Array)   GgaAffx.6483.2.S1_s_at (Chicken Array)   GgaAffx.6483.4.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000044142
Ensembl peptide - ENSGALP00000061031
NCBI entrez gene - 422505     See in Manteia.
RefSeq - XM_015276201
RefSeq - XM_015276198
RefSeq - XM_015276199
RefSeq - XM_015276200
RefSeq - NM_001282289
RefSeq - XM_015276195
RefSeq - XM_015276196
RefSeq - XM_015276197
RefSeq Peptide - NP_001269218
swissprot - A0A1L1RQF9
swissprot - A0A1D5NUX4
Ensembl - ENSGALG00000040909
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wrnENSDARG00000098211Danio rerio
 WRNENSG00000165392Homo sapiens
 WrnENSMUSG00000031583Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
BLM / Bloom syndrome protein homolog / O88700* / P54132* / Bloom syndrome RecQ like helicase*ENSGALG0000000825616
RECQL5 / RecQ like helicase 5 / O94762* / Q8VID5* / ATP-dependent DNA helicase Q5 *ENSGALG0000000242412
RECQL / ATP-dependent DNA helicase Q1 / Q9Z129* / P46063* / RecQ protein-like* / RecQ like helicase*ENSGALG0000001317412


Protein motifs (from Interpro)
Interpro ID Name
 IPR001650  Helicase, C-terminal
 IPR002121  HRDC domain
 IPR002562  3"-5" exonuclease domain
 IPR004589  DNA helicase, ATP-dependent, RecQ type
 IPR010997  HRDC-like superfamily
 IPR011545  DEAD/DEAH box helicase domain
 IPR011991  ArsR-like helix-turn-helix domain
 IPR012337  Ribonuclease H-like superfamily
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR018982  RQC domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR029491  Helicase Helix-turn-helix domain
 IPR032284  ATP-dependent DNA helicase RecQ, zinc-binding domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000723 telomere maintenance IEA
 biological_processGO:0000731 DNA synthesis involved in DNA repair IEA
 biological_processGO:0001302 replicative cell aging IEA
 biological_processGO:0006139 nucleobase-containing compound metabolic process IEA
 biological_processGO:0006259 DNA metabolic process IEA
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006284 base-excision repair IEA
 biological_processGO:0006302 double-strand break repair IEA
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0007569 cell aging IEA
 biological_processGO:0009267 cellular response to starvation IEA
 biological_processGO:0010225 response to UV-C IEA
 biological_processGO:0010259 multicellular organism aging IEA
 biological_processGO:0031297 replication fork processing IEA
 biological_processGO:0032508 DNA duplex unwinding IEA
 biological_processGO:0040009 regulation of growth rate IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0044237 cellular metabolic process IEA
 biological_processGO:0044806 G-quadruplex DNA unwinding IEA
 biological_processGO:0051345 positive regulation of hydrolase activity IEA
 biological_processGO:0061820 telomeric D-loop disassembly IEA
 biological_processGO:0071480 cellular response to gamma radiation IEA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 biological_processGO:0098530 positive regulation of strand invasion IEA
 biological_processGO:1902570 protein localization to nucleolus IEA
 cellular_componentGO:0000781 chromosome, telomeric region IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005657 replication fork IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0032389 MutLalpha complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0000400 four-way junction DNA binding IEA
 molecular_functionGO:0000403 Y-form DNA binding IEA
 molecular_functionGO:0000405 bubble DNA binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003678 DNA helicase activity IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004003 ATP-dependent DNA helicase activity IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0004527 exonuclease activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008026 ATP-dependent helicase activity IEA
 molecular_functionGO:0008408 3"-5" exonuclease activity IEA
 molecular_functionGO:0009378 four-way junction helicase activity IEA
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0030145 manganese ion binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043138 3"-5" DNA helicase activity IEA
 molecular_functionGO:0043140 ATP-dependent 3"-5" DNA helicase activity IEA
 molecular_functionGO:0044877 protein-containing complex binding IEA
 molecular_functionGO:0051880 G-quadruplex DNA binding IEA
 molecular_functionGO:0061749 forked DNA-dependent helicase activity IEA
 molecular_functionGO:0061821 telomeric D-loop binding IEA
 molecular_functionGO:0070337 3"-flap-structured DNA binding IEA
 molecular_functionGO:1905773 8-hydroxy-2"-deoxyguanosine DNA binding IEA


Pathways (from Reactome)
Pathway description
SUMOylation of DNA damage response and repair proteins
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000734 RPA2 / RPA4* / Q13156* / P15927* / replication protein A2* / replication protein A4*  / complex / reaction
 ENSGALG00000002663 ATR / ATR serine/threonine kinase / Q13535*  / complex / reaction
 ENSGALG00000003072 RPA1 / Q5ZJJ2 / Replication protein A 70 kDa DNA-binding subunit / Q8VEE4* / P27694* / replication protein A1*  / complex / reaction
 ENSGALG00000008435 SUMO1 / Q8QGH2 / Small ubiquitin-related modifier 1 / P63166* / P63165* / small ubiquitin-like modifier 1*  / complex / reaction
 ENSGALG00000014982 RBBP8 / RB binding protein 8, endonuclease / Q80YR6* / Q99708* / retinoblastoma binding protein 8, endonuclease*  / complex / reaction
 ENSGALG00000017159 ATM / ATM serine/threonine kinase / Q13315* / Q62388* / Serine-protein kinase ATM *  / complex / reaction
 ENSGALG00000010700 RPA3 / replication protein A3 / P35244* / Q9CQ71* / Replication protein A 14 kDa subunit *  / complex / reaction
 ENSGALG00000017211 MRE11 / double-strand break repair protein MRE11 / Mre11a* / Q61216* / P49959* / MRE11 homolog, double strand break repair nuclease*  / complex / reaction
 ENSGALG00000006794 RAD50* / Q92878* / AC116366.3* / RAD50 double strand break repair protein*  / complex / reaction
 ENSGALG00000004037 DNA2 / Q5ZKG3 / DNA replication ATP-dependent helicase/nuclease DNA2 DNA replication nuclease DNA2 DNA replication ATP-dependent helicase DNA2 / P51530* / Q6ZQJ5* / DNA replication helicase...  / complex
 ENSGALG00000006428 UBE2I / P63283 / SUMO-conjugating enzyme UBC9 / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSGALG00000005279 BRIP1 / Q3YK19 / Fanconi anemia group J protein homolog / Q5SXJ3* / Q9BX63* / BRCA1 interacting protein C-terminal helicase 1*  / complex / reaction






 

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