ENSGALG00000041346


Gallus gallus

Features
Gene ID: ENSGALG00000041346
  
Biological name :CXCL12
  
Synonyms : CXCL12 / C-X-C motif chemokine ligand 12
  
Possible biological names infered from orthology : P40224 / P48061 / Stromal cell-derived factor 1
  
Species: Gallus gallus
  
Chr. number: 6
Strand: -1
Band:
Gene start: 19020439
Gene end: 19033686
  
Corresponding Affymetrix probe sets: Gga.3115.1.S1_at (Chicken Array)   Gga.9513.1.S1_a_at (Chicken Array)   Gga.9513.1.S2_at (Chicken Array)   Gga.9513.2.S2_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000057512
Ensembl peptide - ENSGALP00000058638
Ensembl peptide - ENSGALP00000047558
Ensembl peptide - ENSGALP00000049679
NCBI entrez gene - 395180     See in Manteia.
RefSeq - XM_015288350
RefSeq - NM_204510
RefSeq - XM_015288348
RefSeq - XM_015288349
RefSeq Peptide - NP_989841
swissprot - Q6T7B9
swissprot - Q6T7C0
swissprot - A0A1D5PX22
swissprot - A0A1D5P4F0
Ensembl - ENSGALG00000041346
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cxcl12aENSDARG00000037116Danio rerio
 cxcl12bENSDARG00000055100Danio rerio
 CXCL12ENSG00000107562Homo sapiens
 Cxcl12ENSMUSG00000061353Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001811  Chemokine interleukin-8-like domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0006952 defense response IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007154 cell communication IMP
 biological_processGO:0007411 axon guidance IBA
 biological_processGO:0014812 muscle cell migration IMP
 biological_processGO:0030335 positive regulation of cell migration IMP
 biological_processGO:0033622 integrin activation IEA
 biological_processGO:0045785 positive regulation of cell adhesion IEA
 biological_processGO:0050918 positive chemotaxis IEA
 biological_processGO:0050930 induction of positive chemotaxis IBA
 biological_processGO:0060326 cell chemotaxis IEA
 biological_processGO:0070098 chemokine-mediated signaling pathway IEA
 biological_processGO:0090026 positive regulation of monocyte chemotaxis IEA
 biological_processGO:1901863 positive regulation of muscle tissue development IMP
 biological_processGO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IEA
 biological_processGO:1903237 negative regulation of leukocyte tethering or rolling IEA
 biological_processGO:2000406 positive regulation of T cell migration IEA
 biological_processGO:2000669 negative regulation of dendritic cell apoptotic process IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0009897 external side of plasma membrane IBA
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0008009 chemokine activity IEA
 molecular_functionGO:0042056 chemoattractant activity IBA
 molecular_functionGO:0042379 chemokine receptor binding IEA
 molecular_functionGO:0045236 CXCR chemokine receptor binding IEA


Pathways (from Reactome)
Pathway description
Signaling by ROBO receptors
Chemokine receptors bind chemokines
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000021031 ACKR3 / atypical chemokine receptor 3 / P25106* / P56485*  / complex / reaction
 ENSGALG00000012357 CXCR4 / C-X-C motif chemokine receptor 4 / P61073* / Mus musculus chemokine (C-X-C motif) receptor 4 (Cxcr4), transcript variant 2, mRNA.*  / complex / reaction






 

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