ENSGALG00000042458


Gallus gallus

Features
Gene ID: ENSGALG00000042458
  
Biological name :ACTN1
  
Synonyms : ACTN1 / Alpha-actinin-1 / P05094
  
Possible biological names infered from orthology : actinin alpha 1 / Mus musculus actinin, alpha 1 (Actn1), transcript variant 2, mRNA. / P12814 / Q7TPR4
  
Species: Gallus gallus
  
Chr. number: 5
Strand: 1
Band:
Gene start: 28220078
Gene end: 28311746
  
Corresponding Affymetrix probe sets: Gga.4993.1.S1_at (Chicken Array)   GgaAffx.12773.1.S1_at (Chicken Array)   GgaAffx.12773.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000050182
Ensembl peptide - ENSGALP00000064789
Ensembl peptide - ENSGALP00000051864
Ensembl peptide - ENSGALP00000051375
Ensembl peptide - ENSGALP00000049448
NCBI entrez gene - 373918     See in Manteia.
RefSeq - XM_015287257
RefSeq - XM_015287258
RefSeq - XM_015287259
RefSeq - XM_015287260
RefSeq - NM_204127
RefSeq Peptide - NP_989458
swissprot - P05094
swissprot - A0A1D5PBQ2
swissprot - A0A1D5P9P3
swissprot - A0A1D5PF13
Ensembl - ENSGALG00000042458
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 actn1ENSDARG00000007219Danio rerio
 ACTN1ENSG00000072110Homo sapiens
 Actn1ENSMUSG00000015143Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ACTN2 / P20111 / Alpha-actinin-2 / P35609* / Q9JI91* / actinin alpha 2*ENSGALG0000001446380
SPTBN5 / spectrin beta, non-erythrocytic 5 / Q9NRC6*ENSGALG0000000894031
SPTBN1 / spectrin beta, non-erythrocytic 1 / Q01082* / Q62261* / Spectrin beta chain, non-erythrocytic 1 *ENSGALG0000002951231
SPTB / spectrin beta, erythrocytic / P11277*ENSGALG0000003680528
SPTAN1 / spectrin alpha chain, non-erythrocytic 1 / P16546* / Q13813* / spectrin alpha, non-erythrocytic 1*ENSGALG0000000471919


Protein motifs (from Interpro)
Interpro ID Name
 IPR001589  Actinin-type actin-binding domain, conserved site
 IPR001715  Calponin homology domain
 IPR002017  Spectrin repeat
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR014837  EF-hand, Ca insensitive
 IPR018159  Spectrin/alpha-actinin
 IPR018247  EF-Hand 1, calcium-binding site
 IPR026921  Alpha-actinin 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007015 actin filament organization IEA
 biological_processGO:0030220 platelet formation IEA
 biological_processGO:0036344 platelet morphogenesis IEA
 biological_processGO:0045214 sarcomere organization IMP
 biological_processGO:0048041 focal adhesion assembly IEA
 biological_processGO:0048741 skeletal muscle fiber development IMP
 biological_processGO:0051017 actin filament bundle assembly IEA
 biological_processGO:0051271 negative regulation of cellular component movement IEA
 biological_processGO:0051639 actin filament network formation IEA
 biological_processGO:0051764 actin crosslink formation IEA
 cellular_componentGO:0001725 stress fiber IDA
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005623 cell IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005884 actin filament IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005903 brush border IEA
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0005915 zonula adherens IDA
 cellular_componentGO:0005916 fascia adherens IEA
 cellular_componentGO:0005923 bicellular tight junction IDA
 cellular_componentGO:0005925 focal adhesion IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016328 lateral plasma membrane IDA
 cellular_componentGO:0030017 sarcomere IEA
 cellular_componentGO:0030018 Z disc IEA
 cellular_componentGO:0030027 lamellipodium IDA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030486 smooth muscle dense body IDA
 cellular_componentGO:0031252 cell leading edge IDA
 cellular_componentGO:0042383 sarcolemma IMP
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0090636 outer dense plaque of desmosome IDA
 cellular_componentGO:0090637 inner dense plaque of desmosome IDA
 cellular_componentGO:0097433 dense body IDA
 cellular_componentGO:1990357 terminal web IDA
 molecular_functionGO:0003725 double-stranded RNA binding IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017166 vinculin binding IMP
 molecular_functionGO:0030274 LIM domain binding IPI
 molecular_functionGO:0030374 nuclear receptor transcription coactivator activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0044325 ion channel binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051015 actin filament binding IEA
 molecular_functionGO:0051219 phosphoprotein binding IPI
 molecular_functionGO:0051393 alpha-actinin binding IDA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000014201 PARVB / parvin beta / Q9ES46* / Q9HBI1*  / complex / reaction






 

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