Manteia

ENSGALG00000043603

Gallus gallus

Features

Gene ID:	ENSGALG00000043603

Biological name :	CCL5

Synonyms :	CCL5 / C-C motif chemokine ligand 5

Possible biological names infered from orthology :	C-C motif chemokine 5 / P13501 / P30882

Species:	Gallus gallus

Chr. number:	19
Strand:	-1
Band:
Gene start:	395344
Gene end:	396508

Corresponding Affymetrix probe sets:	Gga.9563.1.S1_at (Chicken Array)

Cross references:	Ensembl peptide - ENSGALP00000049143 NCBI entrez gene - 417465 See in Manteia. RefSeq - NM_001045832 RefSeq Peptide - NP_001039297 swissprot - Q8QG57 Ensembl - ENSGALG00000043603

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
ccl35.1	ENSDARG00000103466	Danio rerio
ccl35.2	ENSDARG00000070378	Danio rerio
CCL5	ENSG00000271503	Homo sapiens
Ccl5	ENSMUSG00000035042	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
CCL4 / Q90826 / C-C motif chemokine 4 homolog / CCL3* / CCL14* / CCL18* / CCL3L1* / P10147* / P10855* / P13236* / P14097* / P16619* / P55774* / Q16627* / Q8NHW4* / CCL4L2* / CCL3L3* / C-C ...	ENSGALG00000032717	52
CCL4 / chemokine C-C motif ligand 4 precursor / CCL3* / CCL18* / CCL14* / Q8NHW4* / CCL3L1* / CCL3L3* / CCL4L2* / P10147* / P10855* / P13236* / P14097* / P16619* / P55774* / Q16627* / C-C ...	ENSGALG00000034478	38
CCL4* / CCL3* / CCL18* / CCL14* / Q8NHW4* / CCL3L1* / CCL3L3* / CCL4L2* / P10147* / P10855* / P13236* / P14097* / P16619* / P55774* / Q16627* / C-C motif chemokine 3 * / C-C motif chemokine...	ENSGALG00000043065	37
CCAH221 / uncharacterized protein LOC417536 precursor / CCL4* / CCL3* / CCL14* / CCL18* / CCL3L3* / P10855* / P13236* / P14097* / P16619* / P55774* / Q16627* / Q8NHW4* / CCL4L2* / CCL3L1* ...	ENSGALG00000027051	36
CCL4* / CCL3* / CCL18* / CCL14* / Q8NHW4* / CCL3L1* / CCL3L3* / CCL4L2* / P10147* / P10855* / P13236* / P14097* / P16619* / P55774* / Q16627* / C-C motif chemokine 3 * / C-C motif chemokine...	ENSGALG00000041079	36
CCL4* / CCL3* / CCL18* / CCL14* / Q8NHW4* / CCL3L1* / CCL3L3* / CCL4L2* / P10147* / P10855* / P13236* / P14097* / P16619* / P55774* / Q16627* / C-C motif chemokine 3 * / C-C motif chemokine...	ENSGALG00000014585	35
CCLL4 / CCL26* / Q9Y258* / C-C motif chemokine ligand 26* / chemokine (C-C motif) ligand 26*	ENSGALG00000034987	35

Protein motifs (from Interpro)

Interpro ID	Name
IPR000827	CC chemokine, conserved site
IPR001811	Chemokine interleukin-8-like domain
IPR030595	C-C motif chemokine 5

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000165	MAPK cascade	IEA
biological_process	GO:0006816	calcium ion transport	IEA
biological_process	GO:0006874	cellular calcium ion homeostasis	IEA
biological_process	GO:0006887	exocytosis	IEA
biological_process	GO:0006935	chemotaxis	IEA
biological_process	GO:0006954	inflammatory response	IEA
biological_process	GO:0006955	immune response	IEA
biological_process	GO:0007159	leukocyte cell-cell adhesion	IEA
biological_process	GO:0007186	G-protein coupled receptor signaling pathway	IEA
biological_process	GO:0007267	cell-cell signaling	IEA
biological_process	GO:0009615	response to virus	IEA
biological_process	GO:0009636	response to toxic substance	IEA
biological_process	GO:0010469	regulation of signaling receptor activity	IEA
biological_process	GO:0010759	positive regulation of macrophage chemotaxis	IEA
biological_process	GO:0010820	positive regulation of T cell chemotaxis	IEA
biological_process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	IEA
biological_process	GO:0014911	positive regulation of smooth muscle cell migration	IEA
biological_process	GO:0030335	positive regulation of cell migration	IEA
biological_process	GO:0031328	positive regulation of cellular biosynthetic process	IEA
biological_process	GO:0031584	activation of phospholipase D activity	IEA
biological_process	GO:0031663	lipopolysaccharide-mediated signaling pathway	IEA
biological_process	GO:0033634	positive regulation of cell-cell adhesion mediated by integrin	IEA
biological_process	GO:0034097	response to cytokine	IEA
biological_process	GO:0034112	positive regulation of homotypic cell-cell adhesion	IEA
biological_process	GO:0034612	response to tumor necrosis factor	IEA
biological_process	GO:0042102	positive regulation of T cell proliferation	IEA
biological_process	GO:0042119	neutrophil activation	IEA
biological_process	GO:0042327	positive regulation of phosphorylation	IEA
biological_process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	IEA
biological_process	GO:0043491	protein kinase B signaling	IEA
biological_process	GO:0043922	negative regulation by host of viral transcription	IEA
biological_process	GO:0044344	cellular response to fibroblast growth factor stimulus	IEA
biological_process	GO:0045071	negative regulation of viral genome replication	IEA
biological_process	GO:0045744	negative regulation of G-protein coupled receptor protein signaling pathway	IEA
biological_process	GO:0045785	positive regulation of cell adhesion	IEA
biological_process	GO:0048245	eosinophil chemotaxis	IEA
biological_process	GO:0048661	positive regulation of smooth muscle cell proliferation	IEA
biological_process	GO:0050679	positive regulation of epithelial cell proliferation	IEA
biological_process	GO:0050796	regulation of insulin secretion	IEA
biological_process	GO:0050863	regulation of T cell activation	IEA
biological_process	GO:0050918	positive chemotaxis	IEA
biological_process	GO:0051262	protein tetramerization	IEA
biological_process	GO:0051928	positive regulation of calcium ion transport	IEA
biological_process	GO:0061098	positive regulation of protein tyrosine kinase activity	IEA
biological_process	GO:0070098	chemokine-mediated signaling pathway	IEA
biological_process	GO:0070100	negative regulation of chemokine-mediated signaling pathway	IEA
biological_process	GO:0070233	negative regulation of T cell apoptotic process	IEA
biological_process	GO:0070234	positive regulation of T cell apoptotic process	IEA
biological_process	GO:0071346	cellular response to interferon-gamma	IEA
biological_process	GO:0071347	cellular response to interleukin-1	IEA
biological_process	GO:0071356	cellular response to tumor necrosis factor	IEA
biological_process	GO:0071407	cellular response to organic cyclic compound	IEA
biological_process	GO:0090026	positive regulation of monocyte chemotaxis	IEA
biological_process	GO:1901214	regulation of neuron death	IEA
biological_process	GO:2000110	negative regulation of macrophage apoptotic process	IEA
biological_process	GO:2000406	positive regulation of T cell migration	IEA
biological_process	GO:2000503	positive regulation of natural killer cell chemotaxis	IEA
cellular_component	GO:0005576	extracellular region	IEA
cellular_component	GO:0005615	extracellular space	IEA
cellular_component	GO:0005737	cytoplasm	IEA
molecular_function	GO:0004435	phosphatidylinositol phospholipase C activity	IEA
molecular_function	GO:0004672	protein kinase activity	IEA
molecular_function	GO:0005125	cytokine activity	IEA
molecular_function	GO:0008009	chemokine activity	IEA
molecular_function	GO:0016004	phospholipase activator activity	IEA
molecular_function	GO:0030298	receptor signaling protein tyrosine kinase activator activity	IEA
molecular_function	GO:0031726	CCR1 chemokine receptor binding	IEA
molecular_function	GO:0031729	CCR4 chemokine receptor binding	IEA
molecular_function	GO:0031730	CCR5 chemokine receptor binding	IEA
molecular_function	GO:0042056	chemoattractant activity	IEA
molecular_function	GO:0042379	chemokine receptor binding	IEA
molecular_function	GO:0042802	identical protein binding	IEA
molecular_function	GO:0042803	protein homodimerization activity	IEA
molecular_function	GO:0043621	protein self-association	IEA
molecular_function	GO:0046817	chemokine receptor antagonist activity	IEA

Pathways (from Reactome)

Pathway description

Chemokine receptors bind chemokines

G alpha (i) signalling events

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSGALG00000011733	CCR2 / C-C chemokine receptor type 2 / CCR1* / CCR5* / CCR3* / P51681* / P51683* / P51675* / P51676* / P51677* / P51678* / P51682* / Ccr1l1* / P32246* / P41597* / C-C motif chemokine recep...	/ complex / reaction
ENSGALG00000037077	CCR5 / CCR1* / CCR3* / CCR2* / P51681* / P41597* / P51675* / P51676* / P51677* / P51678* / P51682* / P51683* / Ccr1l1* / P32246* / C-C motif chemokine receptor 3* / C-C chemokine receptor t...	/ complex / reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr