ENSGALG00000043694


Gallus gallus

Features
Gene ID: ENSGALG00000043694
  
Biological name :RAPGEF4
  
Synonyms : RAPGEF4 / Rap guanine nucleotide exchange factor 4
  
Possible biological names infered from orthology : Q8WZA2 / Q9EQZ6 / Rap guanine nucleotide exchange factor (GEF) 4
  
Species: Gallus gallus
  
Chr. number: 7
Strand: -1
Band:
Gene start: 17506100
Gene end: 17667800
  
Corresponding Affymetrix probe sets: GgaAffx.5902.1.S1_at (Chicken Array)   GgaAffx.5903.1.S1_at (Chicken Array)   GgaAffx.5904.1.S1_at (Chicken Array)   GgaAffx.9017.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000044477
Ensembl peptide - ENSGALP00000053996
Ensembl peptide - ENSGALP00000052612
NCBI entrez gene - 429022     See in Manteia.
RefSeq - XM_015289614
RefSeq - XM_015289611
RefSeq - XM_015289612
RefSeq - XM_015289613
RefSeq - XM_004942736
RefSeq - XM_004942737
RefSeq - XM_015289609
RefSeq - XM_015289610
swissprot - A0A1D5PMC0
swissprot - A0A1D5PIH9
swissprot - A0A1D5NVU8
Ensembl - ENSGALG00000043694
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rapgef4ENSDARG00000079872Danio rerio
 zgc:171558ENSDARG00000075924Danio rerio
 Q8WZA2ENSG00000091428Homo sapiens
 Q9EQZ6ENSMUSG00000049044Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RAPGEF3 / Rap guanine nucleotide exchange factor 3 / O95398* / Q8VCC8* / Mus musculus Rap guanine nucleotide exchange factor (GEF) 3 (Rapgef3), transcript variant 4, mRNA.*ENSGALG0000004377542
Q8TEU7* / RAPGEF6* / AC008695.1* / Rap guanine nucleotide exchange factor 6* / Rap guanine nucleotide exchange factor (GEF) 6*ENSGALG0000002989625
RAPGEF2 / Rap guanine nucleotide exchange factor 2 / Q8CHG7* / Q9Y4G8*ENSGALG0000002024924
RAPGEF5 / Rap guanine nucleotide exchange factor 5 / Q8C0Q9* / Q92565*ENSGALG0000003402424
RAPGEFL1 / Rap guanine nucleotide exchange factor like 1 / Q68EF8* / Q9UHV5*ENSGALG0000003569020
RASGEF1C / RasGEF domain family member 1C / Q8N431* / Q9D300* / Ras-GEF domain-containing family member 1C *ENSGALG000000060769
RASGRP3 / RAS guanyl releasing protein 3 / Q8IV61*ENSGALG000000104359
RASGEF1A / RasGEF domain family member 1A / Q8N9B8*ENSGALG000000025257
RASGRP1 / RAS guanyl releasing protein 1 / O95267* / Q9Z1S3*ENSGALG000000097406
Q0VAM2* / Q8JZL7* / RASGEF1B* / RasGEF domain family member 1B* / Ras-GEF domain-containing family member 1B *ENSGALG000000109033


Protein motifs (from Interpro)
Interpro ID Name
 IPR000591  DEP domain
 IPR000595  Cyclic nucleotide-binding domain
 IPR000651  Ras-like guanine nucleotide exchange factor, N-terminal
 IPR001895  Ras guanine-nucleotide exchange factors catalytic domain
 IPR011991  ArsR-like helix-turn-helix domain
 IPR014710  RmlC-like jelly roll fold
 IPR018490  Cyclic nucleotide-binding-like
 IPR019804  Ras guanine-nucleotide exchange factor, conserved site
 IPR023578  Ras guanine nucleotide exchange factor domain superfamily
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0017156 calcium ion regulated exocytosis IEA
 biological_processGO:0017157 regulation of exocytosis IEA
 biological_processGO:0019933 cAMP-mediated signaling IEA
 biological_processGO:0030073 insulin secretion IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0017016 Ras GTPase binding IEA
 molecular_functionGO:0030552 cAMP binding IEA


Pathways (from Reactome)
Pathway description
Integrin alphaIIb beta3 signaling
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Rap1 signalling
Regulation of insulin secretion


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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