ENSMUSG00000000317


Mus musculus

Features
Gene ID: ENSMUSG00000000317
  
Biological name :Bcl6b
  
Synonyms : B-cell CLL/lymphoma 6 member B protein / Bcl6b / O88282
  
Possible biological names infered from orthology : B cell CLL/lymphoma 6B / Q8N143
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B3
Gene start: 70224128
Gene end: 70229798
  
Corresponding Affymetrix probe sets: 10387797 (MoGene1.0st)   1418421_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000121365
Ensembl peptide - ENSMUSP00000000326
NCBI entrez gene - 12029     See in Manteia.
MGI - MGI:1278332
RefSeq - NM_007528
RefSeq Peptide - NP_031554
swissprot - A2CF73
swissprot - O88282
swissprot - Q5BKP3
Ensembl - ENSMUSG00000000317
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bcl6bENSDARG00000069335Danio rerio
 BCL6BENSG00000161940Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Bcl6 / P41183 / B-cell lymphoma 6 protein homolog / P41182* / B cell CLL/lymphoma 6*ENSMUSG0000002250852
Q8R0A2 / Zbtb44 / zinc finger and BTB domain containing 44 / Q8NCP5*ENSMUSG0000004741221


Protein motifs (from Interpro)
Interpro ID Name
 IPR000210  BTB/POZ domain
 IPR011333  SKP1/BTB/POZ domain superfamily
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0042092 type 2 immune response IBA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0045595 regulation of cell differentiation IBA
 biological_processGO:0050727 regulation of inflammatory response IBA
 cellular_componentGO:0005634 nucleus IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Oattm1Dva/Oattm1Dva
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Oattm1Dva/Oattm1Dva
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Bcl6tm1Sdt/Bcl6tm1Sdt,Bcl6btm2Dent/Bcl6btm2Dent
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bcl6tm1Sdt/Bcl6tm1Sdt
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002429 abnormal blood cell morphology/development "anomalous structure, differentiation, or number of any of the cells found in the blood" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Oattm1Dva/Oattm1Dva
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Bcl6btm2Dent/Bcl6b+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Bcl6btm2Dent/Bcl6btm2Dent,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0002432 abnormal CD4+ T cell morphology/development "anomalous structure, differentiation, or number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Foxo3Gt(XAO26)Byg/Foxo3Gt(XAO26)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0003131 increased erythrocyte count "greater number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Oattm1Dva/Oattm1Dva
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005010 abnormal CD8+ T cell morphology/development "anomalous structure, formation, or numbers of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Foxo3Gt(XAO26)Byg/Foxo3Gt(XAO26)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bcl6btm2Dent/Bcl6btm2Dent,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(rtTA2S*M2)Whsu/Gt(ROSA)26Sortm1(rtTA2S*M2)Whsu
Genetic Background: involves: 129S6/SvEvTac

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Gt(ROSA)26Sortm1(rtTA2S*M2)Whsu/Gt(ROSA)26Sortm1(rtTA2S*M2)Whsu
Genetic Background: involves: 129S6/SvEvTac

 MP:0008050 decreased memory T cell number "reduced number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(rtTA2S*M2)Whsu/Gt(ROSA)26Sortm1(rtTA2S*M2)Whsu
Genetic Background: involves: 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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