ENSMUSG00000001020


Mus musculus

Features
Gene ID: ENSMUSG00000001020
  
Biological name :S100a4
  
Synonyms : P07091 / S100a4 / S100 calcium binding protein A4
  
Possible biological names infered from orthology : P26447
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F1
Gene start: 90603771
Gene end: 90606045
  
Corresponding Affymetrix probe sets: 10493812 (MoGene1.0st)   1424542_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000001046
Ensembl peptide - ENSMUSP00000143522
NCBI entrez gene - 20198     See in Manteia.
MGI - MGI:1330282
RefSeq - XM_006501178
RefSeq - NM_011311
RefSeq - XM_006501177
RefSeq Peptide - NP_035441
swissprot - P07091
swissprot - Q545V2
swissprot - A0A0G2JGD2
Ensembl - ENSMUSG00000001020
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 icnENSDARG00000009978Danio rerio
 icn2ENSDARG00000055514Danio rerio
 s100sENSDARG00000036773Danio rerio
 s100tENSDARG00000055589Danio rerio
 ENSGALG00000037599Gallus gallus
 ENSGALG00000026613Gallus gallus
 P26447ENSG00000196154Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
S100z / S100 calcium binding protein, zeta / Q8WXG8* / S100 calcium binding protein Z*ENSMUSG0000002167947
P62818 / S100a3 / S100 calcium binding protein A3ENSMUSG0000000102146
S100a1 / S100 calcium binding protein A1 / P23297*ENSMUSG0000004408045
P63084 / S100a5 / S100 calcium binding protein A5 / P33763*ENSMUSG0000000102344
P14069 / S100a6 / S100 calcium binding protein A6 (calcyclin) / P06703* / S100 calcium binding protein A6*ENSMUSG0000000102544
S100b / P50114 / S100 protein, beta polypeptide, neural / P04271* / S100 calcium binding protein B*ENSMUSG0000003320840
P08207 / S100a10 / S100 calcium binding protein A10 (calpactin) / P60903* / S100 calcium binding protein A10*ENSMUSG0000004195933
P50543 / S100a11 / Protein S100-A11 / P31949* / S100 calcium binding protein A11*ENSMUSG0000002790730
Gm42674 / P33764* / S100A3* / S100 calcium binding protein A3*ENSMUSG0000010551823


Protein motifs (from Interpro)
Interpro ID Name
 IPR001751  S100/Calbindin-D9k, conserved site
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR013787  S100/CaBP-9k-type, calcium binding, subdomain
 IPR018247  EF-Hand 1, calcium-binding site
 IPR034325  S-100


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046914 transition metal ion binding IEA
 molecular_functionGO:0048306 calcium-dependent protein binding IEA
 molecular_functionGO:0050786 RAGE receptor binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001648 abnormal apoptosis "excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]
Show

Allelic Composition: X/Srydl1Rlb,Tg(Sry)2Ei/0
Genetic Background: involves: 129S6/SvEv * C3H * C57BL/6JEi * MF1

 MP:0001883 mammary adenocarcinoma "higher than normal incidence of malignant tumors of the mammary gland" [J:62919]
Show

Allelic Composition: X/Srydl1Rlb,Tg(Sry)2Ei/0
Genetic Background: involves: 129S6/SvEv * C3H * C57BL/6JEi * MF1

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: X/Srydl1Rlb,Tg(Sry)2Ei/0
Genetic Background: involves: 129S6/SvEv * C3H * C57BL/6JEi * MF1

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Fabp1-cre)1Mmt/?
Genetic Background: involves: 129X1/SvJ

 MP:0002465 abnormal eosinophil physiology "abnormal function of the leukocyte that stains with eosin and is involved in clearance of parasitic infections and in allergic reactions " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Ifngtm3.1Lky/Ifngtm3.1Lky
Genetic Background: B6.129S4-Ifngtm3.1Lky

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: X/Srydl1Rlb,Tg(Sry)2Ei/0
Genetic Background: involves: 129S6/SvEv * C3H * C57BL/6JEi * MF1

 MP:0003799 impaired macrophage migration "defect in the ability of macrophages to move up a chemotactic gradient" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ifngtm3.1Lky/Ifngtm3.1Lky
Genetic Background: B6.129S4-Ifngtm3.1Lky

 MP:0008714 lung carcinoma "a malignant neoplasm of the ling, arising from epithelial cells, usually glandular or squamous" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: X/Srydl1Rlb,Tg(Sry)2Ei/0
Genetic Background: involves: 129S6/SvEv * C3H * C57BL/6JEi * MF1

 MP:0010363 increased fibrosarcoma incidence "greater than the expected number of a highly aggressive malignant neoplasm arising from fibrous connective tissue, in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: X/Srydl1Rlb,Tg(Sry)2Ei/0
Genetic Background: involves: 129S6/SvEv * C3H * C57BL/6JEi * MF1

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: X/Srydl1Rlb,Tg(Sry)2Ei/0
Genetic Background: involves: 129S6/SvEv * C3H * C57BL/6JEi * MF1

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: X/Srydl1Rlb,Tg(Sry)2Ei/0
Genetic Background: involves: 129S6/SvEv * C3H * C57BL/6JEi * MF1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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