ENSMUSG00000001555


Mus musculus

Features
Gene ID: ENSMUSG00000001555
  
Biological name :Fkbp10
  
Synonyms : Fkbp10 / Peptidyl-prolyl cis-trans isomerase FKBP10 / Q61576
  
Possible biological names infered from orthology : FK506 binding protein 10 / Q96AY3
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: D
Gene start: 100415697
Gene end: 100424824
  
Corresponding Affymetrix probe sets: 10381122 (MoGene1.0st)   1415951_at (Mouse Genome 430 2.0 Array)   1449632_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000123577
Ensembl peptide - ENSMUSP00000001595
Ensembl peptide - ENSMUSP00000103023
NCBI entrez gene - 14230     See in Manteia.
MGI - MGI:104769
RefSeq - NM_010221
RefSeq - NM_001163481
RefSeq Peptide - NP_001156953
RefSeq Peptide - NP_034351
swissprot - Q61576
swissprot - F6W360
swissprot - A2A4H9
Ensembl - ENSMUSG00000001555
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fkbp10aENSDARG00000099183Danio rerio
 fkbp10bENSDARG00000045129Danio rerio
 FKBP10ENSGALG00000025764Gallus gallus
 FKBP10ENSG00000141756Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fkbp9 / Q9Z247 / Peptidyl-prolyl cis-trans isomerase FKBP9 / O95302* / FK506 binding protein 9*ENSMUSG0000002978158
Fkbp11 / Q9D1M7 / Peptidyl-prolyl cis-trans isomerase FKBP11 / Q9NYL4* / FK506 binding protein 11*ENSMUSG0000000335512
Fkbp14 / P59024 / Peptidyl-prolyl cis-trans isomerase FKBP14 / Q9NWM8* / FK506 binding protein 14*ENSMUSG0000003807412
Fkbp7 / O54998 / Mus musculus FK506 binding protein 7 (Fkbp7), transcript variant 2, mRNA. / Q9Y680* / FK506 binding protein 7*ENSMUSG0000000273211
Fkbp2 / P45878 / Peptidyl-prolyl cis-trans isomerase FKBP2 / P26885* / FK506 binding protein 2*ENSMUSG000000566299


Protein motifs (from Interpro)
Interpro ID Name
 IPR001179  FKBP-type peptidyl-prolyl cis-trans isomerase domain
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site
 IPR023566  Peptidyl-prolyl cis-trans isomerase, FKBP-type
 IPR026257  FK506-binding protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000412 histone peptidyl-prolyl isomerization IEA
 biological_processGO:0000413 protein peptidyl-prolyl isomerization IEA
 biological_processGO:0018208 peptidyl-proline modification IEA
 biological_processGO:0061077 chaperone-mediated protein folding IBA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005788 endoplasmic reticulum lumen IEA
 molecular_functionGO:0003755 peptidyl-prolyl cis-trans isomerase activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005528 FK506 binding IBA
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Grhl3tm1Bogi/Grhl3+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Grhl3tm1Bogi/Grhl3+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0000550 abnormal forelimb morphology "malformation of the entire anterior extremities" [MGI:tc]
Show

Allelic Composition: Grhl3tm1Bogi/Grhl3+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Grhl3tm1Bogi/Grhl3+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0002591 decreased mean corpuscular volume "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fhl1tm1a(EUCOMM)Wtsi/Fhl1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Fhl1tm1a(EUCOMM)Wtsi/H

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fhl1tm1a(EUCOMM)Wtsi/Fhl1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Fhl1tm1a(EUCOMM)Wtsi/H

 MP:0005564 increased hemoglobin content "increase in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Fhl1tm1a(EUCOMM)Wtsi/Fhl1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Fhl1tm1a(EUCOMM)Wtsi/H

 MP:0008805 decreased circulating amylase level "reduction in the concentration of a group of amylolytic enzymes that cleave starch, glycogen, and related alpha-1,4-glucans in the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:D08.811.277.450.066, MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fhl1tm1a(EUCOMM)Wtsi/Fhl1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Fhl1tm1a(EUCOMM)Wtsi/H

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fhl1tm1a(EUCOMM)Wtsi/Fhl1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Fhl1tm1a(EUCOMM)Wtsi/H

 MP:0009378 abnormal endoplasmic reticulum morphology "any structural anomaly of irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells" [GO:0005783]
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Allelic Composition: Grhl3tm1Bogi/Grhl3+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0010865 prenatal growth retardation "slow or limited development during the prenatal period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grhl3tm1Bogi/Grhl3+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0010997 decreased aorta wall thickness "decreased depth of the part of the aorta that encloses the luminal space" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grhl3tm1Bogi/Grhl3+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Grhl3tm1Bogi/Grhl3+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0011642 abnormal bone collagen fibril morphology "any structural anomaly of the connective tissue bundles in the extracellular matrix of bone tissue that are composed of collagen, and play a role in tissue strength and elasticity" [MGI:csmith]
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Allelic Composition: Grhl3tm1Bogi/Grhl3+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0013258 abnormal extracellular matrix morphology "any structural anomaly of the structure lying external to one or more cells, which provides structural support for cells or tissues; in mammals, the extracellular matrix is completely external to the cell " [GO:0031012]
Show

Allelic Composition: Grhl3tm1Bogi/Grhl3+
Genetic Background: involves: C57BL/6 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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