ENSMUSG00000002731


Mus musculus

Features
Gene ID: ENSMUSG00000002731
  
Biological name :Prkra
  
Synonyms : Interferon-inducible double-stranded RNA-dependent protein kinase activator A / Prkra / Q9WTX2
  
Possible biological names infered from orthology : O75569 / protein activator of interferon induced protein kinase EIF2AK2
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: C3
Gene start: 76629898
Gene end: 76648015
  
Corresponding Affymetrix probe sets: 10483856 (MoGene1.0st)   1447737_at (Mouse Genome 430 2.0 Array)   1448923_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000002808
NCBI entrez gene - 23992     See in Manteia.
MGI - MGI:1344375
RefSeq - XM_017318023
RefSeq - NM_011871
RefSeq - XM_011239517
RefSeq - XM_011239518
RefSeq Peptide - NP_036001
swissprot - Q9WTX2
Ensembl - ENSMUSG00000002731
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prkraENSDARG00000076718Danio rerio
 PRKRAENSG00000180228Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P97473 / Tarbp2 / TARBP2, RISC loading complex RNA binding subunit / Q15633*ENSMUSG0000002305146


Protein motifs (from Interpro)
Interpro ID Name
 IPR014720  Double-stranded RNA-binding domain
 IPR032478  Staufen, C-terminal
 IPR033363  Interferon-inducible double-stranded RNA-dependent protein kinase activator A


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0030422 production of siRNA involved in RNA interference ISS
 biological_processGO:0031047 gene silencing by RNA IEA
 biological_processGO:0031054 pre-miRNA processing IEA
 biological_processGO:0034599 cellular response to oxidative stress IDA
 biological_processGO:0035196 production of miRNAs involved in gene silencing by miRNA IEA
 biological_processGO:0042473 outer ear morphogenesis IMP
 biological_processGO:0042474 middle ear morphogenesis IMP
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0043583 ear development IMP
 biological_processGO:0048705 skeletal system morphogenesis IMP
 biological_processGO:0050821 protein stabilization IEA
 biological_processGO:2001244 positive regulation of intrinsic apoptotic signaling pathway IDA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0070578 RISC-loading complex IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003725 double-stranded RNA binding ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008047 enzyme activator activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0070883 pre-miRNA binding IEA


Pathways (from Reactome)
Pathway description
MicroRNA (miRNA) biogenesis
Small interfering RNA (siRNA) biogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000018 small ears "outer ears of a smaller than normal size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Vegfatm4Pec/Vegfatm4Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Prkralear/Prkralear
Genetic Background: B6(CAST)-Prkralear/GrsrJ

Allelic Composition: Prkrarep/Prkrarep
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Prkralear-3J/Prkralear-3J
Genetic Background: B6.Cg-Prkralear-3J/GrsrJ

Allelic Composition: Itpr3tf/Itpr3tf,Prkralear-5J/Prkralear-5J
Genetic Background: BTBR-Prkralear-5J Itpr3tf/GrsrJ

Allelic Composition: Prkralear-2J/Prkralear-2J
Genetic Background: involves: C57BL/6J

 MP:0000049 abnormal middle ear morphology "malformation or malfunction of any components of the tympanic cavity or its ossicles" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vegfatm4Pec/Vegfatm4Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000074 abnormal neurocranium morphology "malformed bones of the skull enclosing the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
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Allelic Composition: Prkrarep/Prkra+
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nrcamm1Btlr/Nrcamm1Btlr
Genetic Background: C57BL/6J-Nrcamm1Btlr

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
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Allelic Composition: Vegfatm4Pec/Vegfatm4Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
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Allelic Composition: Itpr3tf/Itpr3tf,Prkralear-5J/Prkralear-5J
Genetic Background: BTBR-Prkralear-5J Itpr3tf/GrsrJ

 MP:0000753 paralysis "loss of power of voluntary movement in a muscle through injury or disease of its nerve supply" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Itpr3tf/Itpr3tf,Prkralear-5J/Prkralear-5J
Genetic Background: BTBR-Prkralear-5J Itpr3tf/GrsrJ

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Vegfatm4Pec/Vegfatm4Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Prkrarep/Prkrarep
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Vegfatm4Pec/Vegfatm4Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Prkralear/Prkralear
Genetic Background: B6(CAST)-Prkralear/GrsrJ

Allelic Composition: Prkralear-3J/Prkralear-3J
Genetic Background: B6.Cg-Prkralear-3J/GrsrJ

Allelic Composition: Itpr3tf/Itpr3tf,Prkralear-5J/Prkralear-5J
Genetic Background: BTBR-Prkralear-5J Itpr3tf/GrsrJ

Allelic Composition: Prkralear-2J/Prkralear-2J
Genetic Background: involves: C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Prkrarep/Prkrarep
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Prkralear/Prkralear
Genetic Background: B6(CAST)-Prkralear/GrsrJ

Allelic Composition: Prkralear-2J/Prkralear-2J
Genetic Background: involves: C57BL/6J

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
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Allelic Composition: Prkralear-3J/Prkralear-3J
Genetic Background: B6.Cg-Prkralear-3J/GrsrJ

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Prkrarep/Prkrarep
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Itpr3tf/Itpr3tf,Prkralear-5J/Prkralear-5J
Genetic Background: BTBR-Prkralear-5J Itpr3tf/GrsrJ

 MP:0002177 abnormal outer ear morphology "malformation or malfunction of any components of the auricles or external acoustic meatus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Vegfatm4Pec/Vegfatm4Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Itpr3tf/Itpr3tf,Prkralear-5J/Prkralear-5J
Genetic Background: BTBR-Prkralear-5J Itpr3tf/GrsrJ

 MP:0004384 small interparietal bone "reduced size of the bone of the cranium that lies above and anterior to the occipital bone in some mammals" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkrarep/Prkra+
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0004471 short nasal bone "reduced length of either of two rectangular bone plates forming the bridge of the nose" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Prkrarep/Prkrarep
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Prkrarep/Prkra+
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0004477 turbinate hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, in the small curved bones that extends horizontally along the lateral wall of the nasal passage" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Vegfatm4Pec/Vegfatm4Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005105 abnormal middle ear ossicle morphology "anomalous structure or development of the three small bones of the middle ear" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Vegfatm4Pec/Vegfatm4Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005323 dystonia "impairment of muscle tone resulting in prolonged muscle contraction and involuntary movements such as repetitive movements, or twisting or writhing of the limbs" [J:84533]
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Allelic Composition: Itpr3tf/Itpr3tf,Prkralear-5J/Prkralear-5J
Genetic Background: BTBR-Prkralear-5J Itpr3tf/GrsrJ

 MP:0006033 abnormal external auditory canal "malformation of the canal that connects the outer and middle ear" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:57313]
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Allelic Composition: Vegfatm4Pec/Vegfatm4Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006325 impaired hearing "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkralear/Prkralear
Genetic Background: B6(CAST)-Prkralear/GrsrJ

Allelic Composition: Itpr3tf/Itpr3tf,Prkralear-5J/Prkralear-5J
Genetic Background: BTBR-Prkralear-5J Itpr3tf/GrsrJ

Allelic Composition: Prkralear-2J/Prkralear-2J
Genetic Background: involves: C57BL/6J

 MP:0008273 abnormal intramembranous bone ossification "anomaly in the process of the formation of bone in which osteoblasts secrete a collage-proteoglycan matrix that binds calcium salts and becomes calcified; intramembranous ossification is the way flat bones are formed" [GO:0001957]
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Allelic Composition: Itpr3tf/Itpr3tf,Prkralear-5J/Prkralear-5J
Genetic Background: BTBR-Prkralear-5J Itpr3tf/GrsrJ

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itpr3tf/Itpr3tf,Prkralear-5J/Prkralear-5J
Genetic Background: BTBR-Prkralear-5J Itpr3tf/GrsrJ

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
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Allelic Composition: Adam10tm1Zhu/Adam10tm1Zhu,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL/J

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Vegfatm4Pec/Vegfatm4Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Prkralear-3J/Prkralear-3J
Genetic Background: B6.Cg-Prkralear-3J/GrsrJ

 MP:0030029 wide cranial sutures "an abnormally increased width of one or more cranial sutures for age-related norms, generally resulting from delayed suture closure" [HP:0010537]
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Allelic Composition: Prkrarep/Prkra+
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0030188 round snout "appearance of the anterior facial part of the face or muzzle containing the oral and nasal regions is more circular than usual" [MGI:anna]
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Allelic Composition: Vegfatm4Pec/Vegfatm4Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0030258 small mandibular condyloid process "reduced size of the round bump of bone and constricted neck portion that arises from the upper surface of the mandibular ramus (perpendicular portion) and articulates with the articular disk of the temporomandibular joint" [MGI:anna]
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Allelic Composition: Prkrarep/Prkrarep
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Prkratm1Gcs/Prkratm1Gcs
Genetic Background: Not Specified

 MP:0030261 abnormal temporal bone zygomatic process morphology "any structural anomaly of the long, arched process that projects from the lower region of the squamous part of the temporal bone and articulates with the zygomatic bone; this process is at first directed lateralward, its two surfaces looking upward and downward; it then appears as if twisted inward upon itself, and runs forward, its surfaces now looking medialward and lateralward" [https://en.wikipedia.org/wiki/Zygomatic_process_of_temporal_bone]
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Allelic Composition: Prkrarep/Prkrarep
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0030283 small mandibular coronoid process "reduced size of the thin, flattened, triangular eminence that arises from the upper surface of the mandibular ramus (perpendicular portion)" [MGI:anna]
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Allelic Composition: Prkrarep/Prkrarep
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000036698 Ago2 / Q8CJG0 / Protein argonaute-2 / Q9UKV8* / argonaute 2, RISC catalytic component*  / complex
 ENSMUSG00000041415 Dicer1 / dicer 1, ribonuclease III / Q9UPY3*  / complex






 

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