MP:0000187 | abnormal triglyceride level | "anomalous concentration of this molecule, glycerol esterified at each of its three hydroxyl groups by a fatty acid; triglyceride is an important molecule for storage of fatty acids in adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Iduatm1Clk/Iduatm1Clk Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe Genetic Background: involves: 129S1/Sv
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MP:0000288 | abnormal pericardium morphology | "malformation of the fibroserous membrane covering the heart and beginning of the great vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cml, J:54408] |
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Allelic Composition: Nod2tm1Flv/Nod2tm1Flv Genetic Background: involves: 129S1/Sv
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MP:0000343 | altered response to myocardial infarction | "change in the physiological response to necrosis of the cardiac tissue, often resulting from the sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Iduatm1Clk/Iduatm1Clk Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Cd36tm2.1Mfe/Cd36tm2.1Mfe,A1cfTg(Myh6-cre/Esr1*)1Jmk/0 Genetic Background: B6.Cg-Cd36tm2.1Mfe A1cfTg(Myh6-cre/Esr1*)1Jmk
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MP:0000496 | abnormal small intestine morphology | "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Iduatm1Clk/Iduatm1Clk Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0000609 | abnormal liver physiology | "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Myh10tm2Rsad/Myh10tm2Rsad,Myh14tm1Rsad/Myh14tm1Rsad Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
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MP:0000920 | abnormal myelination | "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe Genetic Background: involves: 129S1/Sv
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MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
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Allelic Composition: Myh10tm2Rsad/Myh10tm2Rsad,Myh14tm1Rsad/Myh14tm1Rsad Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
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MP:0001265 | reduced body size | "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170] |
Show
Allelic Composition: Iduatm1Clk/Iduatm1Clk Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0001432 | abnormal food preference | "the desire to eat more or less food than average, or to eat unusual foods" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Myh10tm2Rsad/Myh10tm2Rsad,Myh14tm1Rsad/Myh14tm1Rsad Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
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MP:0001544 | abnormal cardiovascular system physiology | "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Iduatm1Clk/Iduatm1Clk Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0001547 | abnormal lipid level | "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Myh10tm2Rsad/Myh10tm2Rsad,Myh14tm1Rsad/Myh14tm1Rsad Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cd36tm1Mfe/Cd36tm1Mfe Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
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MP:0001552 | increased circulating triglyceride level | "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416] |
Show
Allelic Composition: Iduatm1Clk/Iduatm1Clk Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe Genetic Background: B6.129S1-Cd36tm1Mfe
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MP:0001554 | increased circulating free fatty acid level | "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146] |
Show
Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe Genetic Background: B6.129S1-Cd36tm1Mfe
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MP:0001556 | increased circulating HDL cholesterol level | "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439] |
Show
Allelic Composition: Iduatm1Clk/Iduatm1Clk Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0001625 | cardiac hypertrophy | "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Iduatm1Clk/Iduatm1Clk Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0001666 | abnormal nutrient absorption | "anomalous ability of the body to take in constituents of food necessary for normal physiologic function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Iduatm1Clk/Iduatm1Clk Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0001669 | abnormal glucose absorption | "anomalous ability of the body to take in this major monosaccharide, a 6-carbon sugar" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Iduatm1Clk/Iduatm1Clk Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0001764 | abnormal homeostasis | "anomaly in the state of equilibrium in the body with respect to various functions and to chemical composition of the fluids and tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Iduatm1Clk/Iduatm1Clk Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0001780 | decreased brown fat amount | "reduced quantity of this thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe Genetic Background: B6.129S1-Cd36tm1Mfe
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MP:0001798 | impaired macrophage phagocytosis | "reduced ability of these phagocytic cells to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Nod2tm1Flv/Nod2tm1Flv Genetic Background: involves: 129S1/Sv
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MP:0001805 | decreased IgG | "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe Genetic Background: B6.129S1-Cd36tm1Mfe
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MP:0001806 | decreased IgM | "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe Genetic Background: B6.129S1-Cd36tm1Mfe
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MP:0001984 | abnormal olfaction | "change in the ability to smell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Pcgf2tm1Hko/Pcgf2+,Sf3b1tm1Hko/Sf3b1+ Genetic Background: involves: C57BL/6
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MP:0002078 | abnormal glucose homeostasis | "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Myh10tm2Rsad/Myh10tm2Rsad,Myh14tm1Rsad/Myh14tm1Rsad Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
Allelic Composition: Cd36tm2.1Mfe/Cd36tm2.1Mfe,A1cfTg(Myh6-cre/Esr1*)1Jmk/0 Genetic Background: B6.Cg-Cd36tm2.1Mfe A1cfTg(Myh6-cre/Esr1*)1Jmk
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MP:0002106 | abnormal muscle physiology | "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe Genetic Background: B6.129S1-Cd36tm1Mfe
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MP:0002118 | abnormal lipid homeostasis | "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Iduatm1Clk/Iduatm1Clk Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0002135 | abnormal kidney morphology | "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Nod2tm1Flv/Nod2tm1Flv Genetic Background: involves: 129S1/Sv
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MP:0002412 | increased susceptibility to bacterial infection | "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Pcgf2tm1Hko/Pcgf2+,Sf3b1tm1Hko/Sf3b1+ Genetic Background: involves: C57BL/6
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MP:0002421 | abnormal cell-mediated immunity | "abnormal function of any adaptive immune response in which T cells play a main role " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Pcgf2tm1Hko/Pcgf2+,Sf3b1tm1Hko/Sf3b1+ Genetic Background: involves: C57BL/6
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MP:0002451 | abnormal macrophage physiology | "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Pcgf2tm1Hko/Pcgf2+,Sf3b1tm1Hko/Sf3b1+ Genetic Background: involves: C57BL/6
Allelic Composition: Cd36tm1Frm/Cd36tm1Frm Genetic Background: involves: 129S4/SvJae * C57BL/6J
Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cd36tm1Mfe/Cd36tm1Mfe Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
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MP:0002460 | decreased circulating immunoglobulin concentration | "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe Genetic Background: B6.129S1-Cd36tm1Mfe
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MP:0002575 | increased circulating ketone body level | "greater than the normal amount of acetoacetate, 3-hydroxybutyrate and acteone in the blood; produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator, J:71968] |
Show
Allelic Composition: Iduatm1Clk/Iduatm1Clk Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe Genetic Background: B6.129S1-Cd36tm1Mfe
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MP:0002644 | decreased circulating triglyceride level | "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe Genetic Background: involves: 129S1/Sv
Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cd36tm1Mfe/Cd36tm1Mfe Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
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MP:0002647 | decreased cholesterol absorption | "reduced ability of the body to take in these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Iduatm1Clk/Iduatm1Clk Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0002865 | increased growth rate | "accelerated time to reach a developmental stage or stages" [J:32208, il:Ira Lu , Mouse Genome Informatics Curator] |
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cd36tm1Mfe/Cd36tm1Mfe Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
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MP:0003383 | abnormal gluconeogenesis | "anomaly in the formation of glucose from noncarbohydrates, such as proteins or fat" [J:93896] |
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Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe Genetic Background: B6.129S1-Cd36tm1Mfe
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MP:0003664 | ocular pterygium | "abnormal mass of tissue arising from the conjunctiva of the inner corner of the eye that obstructs vision by growing over the cornea" [J:96018, monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Pcgf2tm1Hko/Pcgf2+,Sf3b1tm1Hko/Sf3b1+ Genetic Background: involves: C57BL/6
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MP:0003665 | endophthalmitis | "inflammation of the internal structures of the tissues in the eyeball" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96018] |
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Allelic Composition: Pcgf2tm1Hko/Pcgf2+,Sf3b1tm1Hko/Sf3b1+ Genetic Background: involves: C57BL/6
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MP:0003691 | abnormal microglial cell function | "anomalous activity of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [hdene:Howard Dene , Mouse Genome Informatics Curator] |
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(Pax8-rtTA2S*M2)1Koes/0,Tg(tetO-cre)LC1Bjd/0 Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA
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MP:0003692 | xanthoma | "a deposit of cholesterol rich material in a tissue, most often in the skin but also seen in tendons and in the brain" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cd36tm1Mfe/Cd36tm1Mfe Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
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MP:0003949 | abnormal circulating lipid level | "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe Genetic Background: B6.129S1-Cd36tm1Mfe
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MP:0003953 | abnormal hormone level | "aberrant tissue or circulating concentration of any substance, usually a peptide or steroid, that has a specific metabolic regulatory effect on the activity or behavior of cells expressing a receptor for the hormone" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Iduatm1Clk/Iduatm1Clk Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0003975 | increased circulating VLDL triglyceride level | "higher than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator] |
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Allelic Composition: Iduatm1Clk/Iduatm1Clk Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0003982 | increased cholesterol level | "greater than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cd36tm1Mfe/Cd36tm1Mfe Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
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MP:0004016 | decreased bone mass | "a reduction in the total amount of bone tissue contained in the skeleton" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Iduatm1Clk/Iduatm1Clk Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0004220 | abnormal peripheral nervous system regeneration | "changes in the ability or inability of healthy peripheral nervous system tissue to regenerate following injury or disease" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe Genetic Background: involves: 129S1/Sv
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MP:0004893 | decreased adiponectin level | "reduced concentration of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Iduatm1Clk/Iduatm1Clk Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0004939 | abnormal B cell morphology | "any structural anomaly of lymphocytes that expresses membrane-bound immunoglobulin complexes in the mature form, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [CL:0000236, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe Genetic Background: B6.129S1-Cd36tm1Mfe
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MP:0005025 | response to infection | "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Nod2tm1Flv/Nod2tm1Flv Genetic Background: involves: 129S1/Sv
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MP:0005044 | sepsis | "presence of various pathogenic organisms, or their toxins, in the blood or tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:82434] |
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Allelic Composition: Nod2tm1Flv/Nod2tm1Flv Genetic Background: involves: 129S1/Sv
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MP:0005048 | thrombosis | "formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe Genetic Background: B6.129S1-Cd36tm1Mfe
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MP:0005178 | increased total circulating cholesterol level | "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Iduatm1Clk/Iduatm1Clk Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0005278 | abnormal cholesterol homeostasis | "anomaly in the state of equilibrium in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:71350] |
Show
Allelic Composition: Iduatm1Clk/Iduatm1Clk Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0005280 | abnormal fatty acid level | "anomalous concentration of organic, monobasic acids derived from hydrocarbons and which are complexed with serum albumin for transport; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe Genetic Background: B6.129S1-Cd36tm1Mfe
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MP:0005281 | increased fatty acid level | "higher than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Iduatm1Clk/Iduatm1Clk Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe Genetic Background: B6.129S1-Cd36tm1Mfe
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MP:0005282 | decreased fatty acid level | "less than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe Genetic Background: B6.129S1-Cd36tm1Mfe
Allelic Composition: Cd36tm2.1Mfe/Cd36tm2.1Mfe,A1cfTg(Myh6-cre/Esr1*)1Jmk/0 Genetic Background: B6.Cg-Cd36tm2.1Mfe A1cfTg(Myh6-cre/Esr1*)1Jmk
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MP:0005318 | decreased triglyceride level | "lower than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Iduatm1Clk/Iduatm1Clk Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Cd36tm2.1Mfe/Cd36tm2.1Mfe,A1cfTg(Myh6-cre/Esr1*)1Jmk/0 Genetic Background: B6.Cg-Cd36tm2.1Mfe A1cfTg(Myh6-cre/Esr1*)1Jmk
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MP:0005334 | abnormal fat pad | "malformed or aberrant size of the encapsulated adipose tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Iduatm1Clk/Iduatm1Clk Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0005341 | decreased susceptibility to atherosclerosis | "less likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cd36tm1Mfe/Cd36tm1Mfe Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
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MP:0005342 | abnormal lipid absorption | "anomalous ability of the body to take in fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204] |
Show
Allelic Composition: Iduatm1Clk/Iduatm1Clk Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0005439 | decreased glycogen level | "less than the normal concentration of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Iduatm1Clk/Iduatm1Clk Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0005449 | abnormal food intake | "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Iduatm1Clk/Iduatm1Clk Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe Genetic Background: B6.129S1-Cd36tm1Mfe
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MP:0005459 | decreased percent body fat | "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Iduatm1Clk/Iduatm1Clk Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0005560 | decreased circulating glucose level | "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Iduatm1Clk/Iduatm1Clk Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe Genetic Background: involves: 129S1/Sv
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MP:0005666 | abnormal adipose tissue physiology | "functional anomaly of the connective tissue composed of fat cells enmeshed in areolar tissue" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings, 2003] |
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Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe Genetic Background: involves: 129S1/Sv
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MP:0005669 | increased circulating leptin level | "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751] |
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Allelic Composition: Iduatm1Clk/Iduatm1Clk Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0008099 | abnormal plasma cell differentiation | "atypical production of or inability to produce terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe Genetic Background: B6.129S1-Cd36tm1Mfe
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MP:0008189 | increased transitional stage B cell number | "greater number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe Genetic Background: B6.129S1-Cd36tm1Mfe
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MP:0008243 | abnormal foam cell morphology | "any structural anomaly of a type of macrophage containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions" [CL:0000517] |
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cd36tm1Mfe/Cd36tm1Mfe Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
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MP:0008489 | postnatal slow weight gain | "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Iduatm1Clk/Iduatm1Clk Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0008495 | decreased IgG1 level | "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe Genetic Background: B6.129S1-Cd36tm1Mfe
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MP:0008496 | decreased IgG2a level | "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe Genetic Background: B6.129S1-Cd36tm1Mfe
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MP:0008561 | decreased tumor necrosis factor secretion | "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800] |
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Allelic Composition: Nod2tm1Flv/Nod2tm1Flv Genetic Background: involves: 129S1/Sv
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MP:0008664 | decreased interleukin-12 secretion | "reduction in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512] |
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Allelic Composition: Nod2tm1Flv/Nod2tm1Flv Genetic Background: involves: 129S1/Sv
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MP:0008706 | decreased interleukin-6 secretion | "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506] |
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Allelic Composition: Nod2tm1Flv/Nod2tm1Flv Genetic Background: involves: 129S1/Sv
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MP:0008721 | abnormal chemokine level | "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200] |
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Allelic Composition: Cd36tm1Frm/Cd36tm1Frm Genetic Background: involves: 129S4/SvJae * C57BL/6J
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MP:0008897 | decreased IgG2c level | "less than normal immunoglobulin class G2c level" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe Genetic Background: B6.129S1-Cd36tm1Mfe
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MP:0008961 | abnormal basal metabolism | "any anomaly in heat production of an organism at the lowest level of cell chemistry in an inactive, awake, and fasting state" [MESH:E01.370.374.750.100] |
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Allelic Composition: Iduatm1Clk/Iduatm1Clk Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0009355 | increased liver triglyceride level | "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe Genetic Background: B6.129S1-Cd36tm1Mfe
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MP:0009356 | decreased liver triglyceride level | "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe Genetic Background: B6.129S1-Cd36tm1Mfe
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MP:0009763 | increased sensitivity to induced morbidity/mortality | "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pcgf2tm1Hko/Pcgf2+,Sf3b1tm1Hko/Sf3b1+ Genetic Background: involves: C57BL/6
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MP:0009788 | increased susceptibility to bacterial infection induced morbidity/mortality | "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Nod2tm1Flv/Nod2tm1Flv Genetic Background: involves: 129S1/Sv
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MP:0010148 | abnormal exocrine pancreas physiology | "any functional anomaly of the acinar gland portion of the pancreas that secretes digestive enzymes" [MESH:A03.734.540, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe Genetic Background: B6.129S1-Cd36tm1Mfe
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MP:0010360 | decreased liver free fatty acids level | "reduced liver concentration of the fatty acids which occur in plasma as a result of lipolysis in adipose tissue or when plasma triacyglycerols are taken into tissues" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe Genetic Background: B6.129S1-Cd36tm1Mfe
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MP:0010399 | decreased skeletal muscle glycogen level | "less than the normal concentration of a readily converted carbohydrate reserve in skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe Genetic Background: involves: 129S1/Sv
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MP:0010695 | abnormal blood pressure regulation | "any anomaly in the process that modulates the force with which blood travels through the circulatory system, which is controlled by a balance of processes that increase pressure and decrease pressure" [GO:0008217] |
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Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe Genetic Background: involves: 129S1/Sv
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MP:0010760 | abnormal macrophage chemotaxis | "anomaly in the movement of a macrophage guided by a specific chemical concentration gradient" [GO:0048246] |
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Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe Genetic Background: involves: 129S1/Sv
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MP:0011049 | impaired adaptive thermogenesis | "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744] |
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Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe Genetic Background: involves: 129S1/Sv
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MP:0014172 | decreased fatty acid oxidation | |
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Allelic Composition: Cd36tm2.1Mfe/Cd36tm2.1Mfe,A1cfTg(Myh6-cre/Esr1*)1Jmk/0 Genetic Background: B6.Cg-Cd36tm2.1Mfe A1cfTg(Myh6-cre/Esr1*)1Jmk
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MP:0030017 | decreased adipocyte glucose uptake | "reduced ability of adipocytes to take in glucose" [MGI:anna] |
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Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe Genetic Background: involves: 129S1/Sv
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MP:0030018 | increased cardiac cell glucose uptake | "increased ability of the cells of the heart to take in glucose" [MGI:anna] |
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Allelic Composition: Iduatm1Clk/Iduatm1Clk Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0030022 | decreased muscle cell glucose uptake | "reduced ability of muscle cells to take in glucose" [MGI:anna] |
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Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe Genetic Background: involves: 129S1/Sv
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