ENSMUSG00000002944


Mus musculus

Features
Gene ID: ENSMUSG00000002944
  
Biological name :Cd36
  
Synonyms : Cd36 / Platelet glycoprotein 4 / Q08857
  
Possible biological names infered from orthology : CD36 molecule / P16671
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: A3
Gene start: 17781690
Gene end: 17888801
  
Corresponding Affymetrix probe sets: 10528207 (MoGene1.0st)   1423166_at (Mouse Genome 430 2.0 Array)   1450883_a_at (Mouse Genome 430 2.0 Array)   1450884_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000143107
Ensembl peptide - ENSMUSP00000133008
Ensembl peptide - ENSMUSP00000143061
Ensembl peptide - ENSMUSP00000080974
Ensembl peptide - ENSMUSP00000126300
Ensembl peptide - ENSMUSP00000131832
NCBI entrez gene - 12491     See in Manteia.
MGI - MGI:107899
RefSeq - XM_006535625
RefSeq - NM_001159555
RefSeq - NM_001159556
RefSeq - NM_001159557
RefSeq - NM_001159558
RefSeq - NM_007643
RefSeq - XM_006535620
RefSeq - XM_006535621
RefSeq - XM_006535622
RefSeq - XM_006535623
RefSeq - XM_006535624
RefSeq Peptide - NP_031669
RefSeq Peptide - NP_001153028
RefSeq Peptide - NP_001153029
RefSeq Peptide - NP_001153030
RefSeq Peptide - NP_001153027
swissprot - Q3UAI3
swissprot - A0A0G2JFB7
swissprot - Q08857
Ensembl - ENSMUSG00000002944
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cd36ENSDARG00000032639Danio rerio
 CD36ENSGALG00000008439Gallus gallus
 CD36ENSG00000135218Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O35114 / Scarb2 / Lysosome membrane protein 2 / Q14108* / scavenger receptor class B member 2*ENSMUSG0000002942631
Q61009 / Scarb1 / Scavenger receptor class B member 1 / Q8WTV0*ENSMUSG0000003793629


Protein motifs (from Interpro)
Interpro ID Name
 IPR002159  CD36 family
 IPR005428  CD36/scavenger receptor class B member 1
 IPR033076  CD36


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0001954 positive regulation of cell-matrix adhesion IEA
 biological_processGO:0002221 pattern recognition receptor signaling pathway IEA
 biological_processGO:0006910 phagocytosis, recognition IDA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IDA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IDA
 biological_processGO:0007263 nitric oxide mediated signal transduction IEA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0010744 positive regulation of macrophage derived foam cell differentiation IEA
 biological_processGO:0010886 positive regulation of cholesterol storage IMP
 biological_processGO:0010942 positive regulation of cell death IEA
 biological_processGO:0019915 lipid storage IEA
 biological_processGO:0019934 cGMP-mediated signaling IEA
 biological_processGO:0030194 positive regulation of blood coagulation IMP
 biological_processGO:0030299 intestinal cholesterol absorption IMP
 biological_processGO:0030301 cholesterol transport IMP
 biological_processGO:0031623 receptor internalization IDA
 biological_processGO:0032735 positive regulation of interleukin-12 production IMP
 biological_processGO:0032755 positive regulation of interleukin-6 production IMP
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IMP
 biological_processGO:0033993 response to lipid IDA
 biological_processGO:0034121 regulation of toll-like receptor signaling pathway IEA
 biological_processGO:0034197 triglyceride transport IMP
 biological_processGO:0034381 plasma lipoprotein particle clearance IMP
 biological_processGO:0034383 low-density lipoprotein particle clearance IEA
 biological_processGO:0035634 response to stilbenoid IEP
 biological_processGO:0042953 lipoprotein transport IMP
 biological_processGO:0042992 obsolete negative regulation of transcription factor import into nucleus IMP
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
 biological_processGO:0043277 apoptotic cell clearance IMP
 biological_processGO:0043410 positive regulation of MAPK cascade IMP
 biological_processGO:0043497 regulation of protein heterodimerization activity IEA
 biological_processGO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress IC
 biological_processGO:0044130 negative regulation of growth of symbiont in host IMP
 biological_processGO:0044539 long-chain fatty acid import IMP
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process IGI
 biological_processGO:0050702 interleukin-1 beta secretion IDA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0050830 defense response to Gram-positive bacterium IMP
 biological_processGO:0050892 intestinal absorption IMP
 biological_processGO:0050909 sensory perception of taste IDA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0055096 low-density lipoprotein particle mediated signaling IDA
 biological_processGO:0060100 positive regulation of phagocytosis, engulfment IMP
 biological_processGO:0060907 positive regulation of macrophage cytokine production IMP
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:0070508 cholesterol import IMP
 biological_processGO:0070542 response to fatty acid IMP
 biological_processGO:0070543 response to linoleic acid IDA
 biological_processGO:0071221 cellular response to bacterial lipopeptide IMP
 biological_processGO:0071222 cellular response to lipopolysaccharide IMP
 biological_processGO:0071223 cellular response to lipoteichoic acid IMP
 biological_processGO:0071404 cellular response to low-density lipoprotein particle stimulus IDA
 biological_processGO:0071447 cellular response to hydroperoxide IMP
 biological_processGO:0071726 cellular response to diacyl bacterial lipopeptide IEA
 biological_processGO:0140052 cellular response to oxidised low-density lipoprotein particle stimulus IEA
 biological_processGO:0150024 oxidised low-density lipoprotein particle clearance IEA
 biological_processGO:1900227 positive regulation of NLRP3 inflammasome complex assembly IDA
 biological_processGO:1903428 positive regulation of reactive oxygen species biosynthetic process IMP
 biological_processGO:1904646 cellular response to amyloid-beta IEA
 biological_processGO:1990000 amyloid fibril formation IDA
 biological_processGO:2000121 regulation of removal of superoxide radicals IMP
 biological_processGO:2000334 positive regulation of blood microparticle formation IMP
 biological_processGO:2000379 positive regulation of reactive oxygen species metabolic process IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0031526 brush border membrane IDA
 cellular_componentGO:0043235 receptor complex IEA
 cellular_componentGO:0045121 membrane raft ISO
 cellular_componentGO:0045177 apical part of cell IDA
 molecular_functionGO:0005041 low-density lipoprotein particle receptor activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008035 high-density lipoprotein particle binding IDA
 molecular_functionGO:0008289 lipid binding ISS
 molecular_functionGO:0030169 low-density lipoprotein particle binding IEA
 molecular_functionGO:0035325 Toll-like receptor binding IEA
 molecular_functionGO:0070892 lipoteichoic acid receptor activity IMP
 molecular_functionGO:0071813 lipoprotein particle binding IEA
 molecular_functionGO:0150025 oxidised low-density lipoprotein particle receptor activity IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Cross-presentation of particulate exogenous antigens (phagosomes)
Scavenging by Class B Receptors
Regulation of TLR by endogenous ligand
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000187 abnormal triglyceride level "anomalous concentration of this molecule, glycerol esterified at each of its three hydroxyl groups by a fatty acid; triglyceride is an important molecule for storage of fatty acids in adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Iduatm1Clk/Iduatm1Clk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe
Genetic Background: involves: 129S1/Sv

 MP:0000288 abnormal pericardium morphology "malformation of the fibroserous membrane covering the heart and beginning of the great vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cml, J:54408]
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Allelic Composition: Nod2tm1Flv/Nod2tm1Flv
Genetic Background: involves: 129S1/Sv

 MP:0000343 altered response to myocardial infarction "change in the physiological response to necrosis of the cardiac tissue, often resulting from the sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Iduatm1Clk/Iduatm1Clk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Cd36tm2.1Mfe/Cd36tm2.1Mfe,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: B6.Cg-Cd36tm2.1Mfe A1cfTg(Myh6-cre/Esr1*)1Jmk

 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Iduatm1Clk/Iduatm1Clk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Myh10tm2Rsad/Myh10tm2Rsad,Myh14tm1Rsad/Myh14tm1Rsad
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe
Genetic Background: involves: 129S1/Sv

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Myh10tm2Rsad/Myh10tm2Rsad,Myh14tm1Rsad/Myh14tm1Rsad
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Iduatm1Clk/Iduatm1Clk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001432 abnormal food preference "the desire to eat more or less food than average, or to eat unusual foods" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myh10tm2Rsad/Myh10tm2Rsad,Myh14tm1Rsad/Myh14tm1Rsad
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Iduatm1Clk/Iduatm1Clk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Myh10tm2Rsad/Myh10tm2Rsad,Myh14tm1Rsad/Myh14tm1Rsad
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cd36tm1Mfe/Cd36tm1Mfe
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Iduatm1Clk/Iduatm1Clk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe
Genetic Background: B6.129S1-Cd36tm1Mfe

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe
Genetic Background: B6.129S1-Cd36tm1Mfe

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
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Allelic Composition: Iduatm1Clk/Iduatm1Clk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Iduatm1Clk/Iduatm1Clk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001666 abnormal nutrient absorption "anomalous ability of the body to take in constituents of food necessary for normal physiologic function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Iduatm1Clk/Iduatm1Clk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001669 abnormal glucose absorption "anomalous ability of the body to take in this major monosaccharide, a 6-carbon sugar" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Iduatm1Clk/Iduatm1Clk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001764 abnormal homeostasis "anomaly in the state of equilibrium in the body with respect to various functions and to chemical composition of the fluids and tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Iduatm1Clk/Iduatm1Clk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001780 decreased brown fat amount "reduced quantity of this thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe
Genetic Background: B6.129S1-Cd36tm1Mfe

 MP:0001798 impaired macrophage phagocytosis "reduced ability of these phagocytic cells to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nod2tm1Flv/Nod2tm1Flv
Genetic Background: involves: 129S1/Sv

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe
Genetic Background: B6.129S1-Cd36tm1Mfe

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe
Genetic Background: B6.129S1-Cd36tm1Mfe

 MP:0001984 abnormal olfaction "change in the ability to smell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pcgf2tm1Hko/Pcgf2+,Sf3b1tm1Hko/Sf3b1+
Genetic Background: involves: C57BL/6

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myh10tm2Rsad/Myh10tm2Rsad,Myh14tm1Rsad/Myh14tm1Rsad
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Cd36tm2.1Mfe/Cd36tm2.1Mfe,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: B6.Cg-Cd36tm2.1Mfe A1cfTg(Myh6-cre/Esr1*)1Jmk

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe
Genetic Background: B6.129S1-Cd36tm1Mfe

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Iduatm1Clk/Iduatm1Clk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nod2tm1Flv/Nod2tm1Flv
Genetic Background: involves: 129S1/Sv

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pcgf2tm1Hko/Pcgf2+,Sf3b1tm1Hko/Sf3b1+
Genetic Background: involves: C57BL/6

 MP:0002421 abnormal cell-mediated immunity "abnormal function of any adaptive immune response in which T cells play a main role " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pcgf2tm1Hko/Pcgf2+,Sf3b1tm1Hko/Sf3b1+
Genetic Background: involves: C57BL/6

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pcgf2tm1Hko/Pcgf2+,Sf3b1tm1Hko/Sf3b1+
Genetic Background: involves: C57BL/6

Allelic Composition: Cd36tm1Frm/Cd36tm1Frm
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cd36tm1Mfe/Cd36tm1Mfe
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe
Genetic Background: B6.129S1-Cd36tm1Mfe

 MP:0002575 increased circulating ketone body level "greater than the normal amount of acetoacetate, 3-hydroxybutyrate and acteone in the blood; produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator, J:71968]
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Allelic Composition: Iduatm1Clk/Iduatm1Clk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe
Genetic Background: B6.129S1-Cd36tm1Mfe

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe
Genetic Background: involves: 129S1/Sv

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cd36tm1Mfe/Cd36tm1Mfe
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0002647 decreased cholesterol absorption "reduced ability of the body to take in these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Iduatm1Clk/Iduatm1Clk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002865 increased growth rate "accelerated time to reach a developmental stage or stages" [J:32208, il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cd36tm1Mfe/Cd36tm1Mfe
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0003383 abnormal gluconeogenesis "anomaly in the formation of glucose from noncarbohydrates, such as proteins or fat" [J:93896]
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Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe
Genetic Background: B6.129S1-Cd36tm1Mfe

 MP:0003664 ocular pterygium "abnormal mass of tissue arising from the conjunctiva of the inner corner of the eye that obstructs vision by growing over the cornea" [J:96018, monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Pcgf2tm1Hko/Pcgf2+,Sf3b1tm1Hko/Sf3b1+
Genetic Background: involves: C57BL/6

 MP:0003665 endophthalmitis "inflammation of the internal structures of the tissues in the eyeball" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96018]
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Allelic Composition: Pcgf2tm1Hko/Pcgf2+,Sf3b1tm1Hko/Sf3b1+
Genetic Background: involves: C57BL/6

 MP:0003691 abnormal microglial cell function "anomalous activity of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(Pax8-rtTA2S*M2)1Koes/0,Tg(tetO-cre)LC1Bjd/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA

 MP:0003692 xanthoma "a deposit of cholesterol rich material in a tissue, most often in the skin but also seen in tendons and in the brain" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cd36tm1Mfe/Cd36tm1Mfe
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0003949 abnormal circulating lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe
Genetic Background: B6.129S1-Cd36tm1Mfe

 MP:0003953 abnormal hormone level "aberrant tissue or circulating concentration of any substance, usually a peptide or steroid, that has a specific metabolic regulatory effect on the activity or behavior of cells expressing a receptor for the hormone" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Iduatm1Clk/Iduatm1Clk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003975 increased circulating VLDL triglyceride level "higher than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Iduatm1Clk/Iduatm1Clk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003982 increased cholesterol level "greater than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cd36tm1Mfe/Cd36tm1Mfe
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0004016 decreased bone mass "a reduction in the total amount of bone tissue contained in the skeleton" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Iduatm1Clk/Iduatm1Clk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004220 abnormal peripheral nervous system regeneration "changes in the ability or inability of healthy peripheral nervous system tissue to regenerate following injury or disease" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe
Genetic Background: involves: 129S1/Sv

 MP:0004893 decreased adiponectin level "reduced concentration of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Iduatm1Clk/Iduatm1Clk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004939 abnormal B cell morphology "any structural anomaly of lymphocytes that expresses membrane-bound immunoglobulin complexes in the mature form, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [CL:0000236, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe
Genetic Background: B6.129S1-Cd36tm1Mfe

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nod2tm1Flv/Nod2tm1Flv
Genetic Background: involves: 129S1/Sv

 MP:0005044 sepsis "presence of various pathogenic organisms, or their toxins, in the blood or tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:82434]
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Allelic Composition: Nod2tm1Flv/Nod2tm1Flv
Genetic Background: involves: 129S1/Sv

 MP:0005048 thrombosis "formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe
Genetic Background: B6.129S1-Cd36tm1Mfe

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Iduatm1Clk/Iduatm1Clk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005278 abnormal cholesterol homeostasis "anomaly in the state of equilibrium in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:71350]
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Allelic Composition: Iduatm1Clk/Iduatm1Clk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005280 abnormal fatty acid level "anomalous concentration of organic, monobasic acids derived from hydrocarbons and which are complexed with serum albumin for transport; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe
Genetic Background: B6.129S1-Cd36tm1Mfe

 MP:0005281 increased fatty acid level "higher than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Iduatm1Clk/Iduatm1Clk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe
Genetic Background: B6.129S1-Cd36tm1Mfe

 MP:0005282 decreased fatty acid level "less than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe
Genetic Background: B6.129S1-Cd36tm1Mfe

Allelic Composition: Cd36tm2.1Mfe/Cd36tm2.1Mfe,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: B6.Cg-Cd36tm2.1Mfe A1cfTg(Myh6-cre/Esr1*)1Jmk

 MP:0005318 decreased triglyceride level "lower than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Iduatm1Clk/Iduatm1Clk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Cd36tm2.1Mfe/Cd36tm2.1Mfe,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: B6.Cg-Cd36tm2.1Mfe A1cfTg(Myh6-cre/Esr1*)1Jmk

 MP:0005334 abnormal fat pad "malformed or aberrant size of the encapsulated adipose tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Iduatm1Clk/Iduatm1Clk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005341 decreased susceptibility to atherosclerosis "less likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cd36tm1Mfe/Cd36tm1Mfe
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0005342 abnormal lipid absorption "anomalous ability of the body to take in fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Iduatm1Clk/Iduatm1Clk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005439 decreased glycogen level "less than the normal concentration of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Iduatm1Clk/Iduatm1Clk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Iduatm1Clk/Iduatm1Clk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe
Genetic Background: B6.129S1-Cd36tm1Mfe

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Iduatm1Clk/Iduatm1Clk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Iduatm1Clk/Iduatm1Clk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe
Genetic Background: involves: 129S1/Sv

 MP:0005666 abnormal adipose tissue physiology "functional anomaly of the connective tissue composed of fat cells enmeshed in areolar tissue" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe
Genetic Background: involves: 129S1/Sv

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Iduatm1Clk/Iduatm1Clk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008099 abnormal plasma cell differentiation "atypical production of or inability to produce terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe
Genetic Background: B6.129S1-Cd36tm1Mfe

 MP:0008189 increased transitional stage B cell number "greater number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe
Genetic Background: B6.129S1-Cd36tm1Mfe

 MP:0008243 abnormal foam cell morphology "any structural anomaly of a type of macrophage containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions" [CL:0000517]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cd36tm1Mfe/Cd36tm1Mfe
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Iduatm1Clk/Iduatm1Clk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe
Genetic Background: B6.129S1-Cd36tm1Mfe

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe
Genetic Background: B6.129S1-Cd36tm1Mfe

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Nod2tm1Flv/Nod2tm1Flv
Genetic Background: involves: 129S1/Sv

 MP:0008664 decreased interleukin-12 secretion "reduction in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
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Allelic Composition: Nod2tm1Flv/Nod2tm1Flv
Genetic Background: involves: 129S1/Sv

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Nod2tm1Flv/Nod2tm1Flv
Genetic Background: involves: 129S1/Sv

 MP:0008721 abnormal chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
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Allelic Composition: Cd36tm1Frm/Cd36tm1Frm
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0008897 decreased IgG2c level "less than normal immunoglobulin class G2c level" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe
Genetic Background: B6.129S1-Cd36tm1Mfe

 MP:0008961 abnormal basal metabolism "any anomaly in heat production of an organism at the lowest level of cell chemistry in an inactive, awake, and fasting state" [MESH:E01.370.374.750.100]
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Allelic Composition: Iduatm1Clk/Iduatm1Clk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe
Genetic Background: B6.129S1-Cd36tm1Mfe

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe
Genetic Background: B6.129S1-Cd36tm1Mfe

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pcgf2tm1Hko/Pcgf2+,Sf3b1tm1Hko/Sf3b1+
Genetic Background: involves: C57BL/6

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nod2tm1Flv/Nod2tm1Flv
Genetic Background: involves: 129S1/Sv

 MP:0010148 abnormal exocrine pancreas physiology "any functional anomaly of the acinar gland portion of the pancreas that secretes digestive enzymes" [MESH:A03.734.540, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe
Genetic Background: B6.129S1-Cd36tm1Mfe

 MP:0010360 decreased liver free fatty acids level "reduced liver concentration of the fatty acids which occur in plasma as a result of lipolysis in adipose tissue or when plasma triacyglycerols are taken into tissues" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe
Genetic Background: B6.129S1-Cd36tm1Mfe

 MP:0010399 decreased skeletal muscle glycogen level "less than the normal concentration of a readily converted carbohydrate reserve in skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe
Genetic Background: involves: 129S1/Sv

 MP:0010695 abnormal blood pressure regulation "any anomaly in the process that modulates the force with which blood travels through the circulatory system, which is controlled by a balance of processes that increase pressure and decrease pressure" [GO:0008217]
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Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe
Genetic Background: involves: 129S1/Sv

 MP:0010760 abnormal macrophage chemotaxis "anomaly in the movement of a macrophage guided by a specific chemical concentration gradient" [GO:0048246]
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Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe
Genetic Background: involves: 129S1/Sv

 MP:0011049 impaired adaptive thermogenesis "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744]
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Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe
Genetic Background: involves: 129S1/Sv

 MP:0014172 decreased fatty acid oxidation 
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Allelic Composition: Cd36tm2.1Mfe/Cd36tm2.1Mfe,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: B6.Cg-Cd36tm2.1Mfe A1cfTg(Myh6-cre/Esr1*)1Jmk

 MP:0030017 decreased adipocyte glucose uptake "reduced ability of adipocytes to take in glucose" [MGI:anna]
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Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe
Genetic Background: involves: 129S1/Sv

 MP:0030018 increased cardiac cell glucose uptake "increased ability of the cells of the heart to take in glucose" [MGI:anna]
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Allelic Composition: Iduatm1Clk/Iduatm1Clk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0030022 decreased muscle cell glucose uptake "reduced ability of muscle cells to take in glucose" [MGI:anna]
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Allelic Composition: Cd36tm1Mfe/Cd36tm1Mfe
Genetic Background: involves: 129S1/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000039005 Tlr4 / Q9QUK6 / toll-like receptor 4 / O00206*  / complex / reaction
 ENSMUSG00000051498 Tlr6 / toll-like receptor 6 / Q9Y2C9*  / complex / reaction






 

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