ENSMUSG00000004098


Mus musculus

Features
Gene ID: ENSMUSG00000004098
  
Biological name :Col5a3
  
Synonyms : Col5a3 / collagen, type V, alpha 3
  
Possible biological names infered from orthology : collagen type V alpha 3 chain / P25940
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A3
Gene start: 20770050
Gene end: 20815067
  
Corresponding Affymetrix probe sets: 10591281 (MoGene1.0st)   1419703_at (Mouse Genome 430 2.0 Array)   1425984_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000004201
NCBI entrez gene - 53867     See in Manteia.
MGI - MGI:1858212
RefSeq - XM_017313471
RefSeq - NM_001317388
RefSeq - NM_016919
RefSeq Peptide - NP_058615
RefSeq Peptide - NP_001304317
swissprot - Q9JLI2
Ensembl - ENSMUSG00000004098
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 col5a3aENSDARG00000098294Danio rerio
 col5a3bENSDARG00000101816Danio rerio
 COL5A3ENSG00000080573Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Col5a1 / O88207 / Collagen alpha-1(V) chain / P20908* / collagen type V alpha 1 chain*ENSMUSG0000002683759
Q61245 / Col11a1 / Collagen alpha-1(XI) chain / P12107* / collagen type XI alpha 1 chain*ENSMUSG0000002796657
Q64739 / Col11a2 / Collagen alpha-2(XI) chain / P13942* / collagen type XI alpha 2 chain*ENSMUSG0000002433053
Col1a1 / P11087 / Collagen alpha-1(I) chain / P02452* / collagen type I alpha 1 chain*ENSMUSG0000000150636
Col2a1 / P28481 / Collagen alpha-1(II) chain Collagen alpha-1(II) chain Chondrocalcin / P02458* / collagen type II alpha 1 chain*ENSMUSG0000002248336
Col5a2 / Q3U962 / Collagen alpha-2(V) chain / P05997* / collagen type V alpha 2 chain*ENSMUSG0000002604235
Col3a1 / P08121 / Collagen alpha-1(III) chain / P02461* / collagen type III alpha 1 chain*ENSMUSG0000002604335
Col1a2 / Q01149 / Collagen alpha-2(I) chain / P08123* / collagen type I alpha 2 chain*ENSMUSG0000002966134
Q5QNQ9 / Col27a1 / Collagen alpha-1(XXVII) chain / Q8IZC6* / collagen type XXVII alpha 1 chain*ENSMUSG0000004567234
Q30D77 / Col24a1 / Collagen alpha-1(XXIV) chain / Q17RW2* / collagen type XXIV alpha 1 chain*ENSMUSG0000002819732


Protein motifs (from Interpro)
Interpro ID Name
 IPR000885  Fibrillar collagen, C-terminal
 IPR001791  Laminin G domain
 IPR008160  Collagen triple helix repeat
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR016133  Insect cysteine-rich antifreeze protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007160 cell-matrix adhesion IDA
 biological_processGO:0030198 extracellular matrix organization ISS
 cellular_componentGO:0005581 collagen trimer IEA
 cellular_componentGO:0005588 collagen type V trimer IDA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0005198 structural molecule activity ISS
 molecular_functionGO:0005201 extracellular matrix structural constituent IEA
 molecular_functionGO:0008201 heparin binding IDA
 molecular_functionGO:0043394 proteoglycan binding IEA


Pathways (from Reactome)
Pathway description
Collagen degradation
Extracellular matrix organization
Collagen biosynthesis and modifying enzymes
Signaling by PDGF
Assembly of collagen fibrils and other multimeric structures
Integrin cell surface interactions
Non-integrin membrane-ECM interactions
ECM proteoglycans
NCAM1 interactions
MET activates PTK2 signaling
Collagen chain trimerization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Trp53tm3.1Glo/Trp53tm4Glo,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Trp53tm3.1Glo/Trp53tm4Glo,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Trp53tm3.1Glo/Trp53tm4Glo,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp53tm3.1Glo/Trp53tm4Glo,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0002693 abnormal pancreas physiology "abberrant function of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Trp53tm3.1Glo/Trp53tm4Glo,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp53tm3.1Glo/Trp53tm4Glo,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Trp53tm3.1Glo/Trp53tm4Glo,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0003339 decreased number of pancreatic beta cells "fewer than normal number of the cells of the pancreas that secrete insulin" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Trp53tm3.1Glo/Trp53tm4Glo,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Trp53tm3.1Glo/Trp53tm4Glo,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Trp53tm3.1Glo/Trp53tm4Glo,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Trp53tm3.1Glo/Trp53tm4Glo,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0008844 decreased subcutaneous adipose tissue amount "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Trp53tm3.1Glo/Trp53tm4Glo,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trp53tm3.1Glo/Trp53tm4Glo,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0009109 decreased pancreas weight "reduction in the average weight of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [MESH:A03.734, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trp53tm3.1Glo/Trp53tm4Glo,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0009114 decreased pancreatic beta cell mass "reduced total physical bulk or volume of a pancreatic beta cell compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trp53tm3.1Glo/Trp53tm4Glo,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0014117 increased pancreatic beta cell apoptosis "increase in the number of pancreatic beta cells undergoing programmed cell death" [MGI:Anna]
Show

Allelic Composition: Trp53tm3.1Glo/Trp53tm4Glo,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0014121 increased pancreatic islet cell apoptosis "increase in the number of pancreatic islet cells undergoing programmed cell death" [MGI:Anna]
Show

Allelic Composition: Trp53tm3.1Glo/Trp53tm4Glo,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0030017 decreased adipocyte glucose uptake "reduced ability of adipocytes to take in glucose" [MGI:anna]
Show

Allelic Composition: Trp53tm3.1Glo/Trp53tm4Glo,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0030022 decreased muscle cell glucose uptake "reduced ability of muscle cells to take in glucose" [MGI:anna]
Show

Allelic Composition: Trp53tm3.1Glo/Trp53tm4Glo,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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