ENSMUSG00000004127


Mus musculus

Features
Gene ID: ENSMUSG00000004127
  
Biological name :Trmt10a
  
Synonyms : Trmt10a / tRNA methyltransferase 10A
  
Possible biological names infered from orthology : Q8TBZ6
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: G3
Gene start: 138143448
Gene end: 138159821
  
Corresponding Affymetrix probe sets: 10496417 (MoGene1.0st)   1427375_at (Mouse Genome 430 2.0 Array)   1435035_at (Mouse Genome 430 2.0 Array)   1447781_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000130478
Ensembl peptide - ENSMUSP00000042082
Ensembl peptide - ENSMUSP00000124465
Ensembl peptide - ENSMUSP00000125681
Ensembl peptide - ENSMUSP00000125749
NCBI entrez gene - 108943     See in Manteia.
MGI - MGI:1920421
RefSeq - XM_011239983
RefSeq - NM_001348196
RefSeq - NM_001348197
RefSeq - NM_175389
RefSeq - XM_006500843
RefSeq - XM_006500844
RefSeq - XM_006500846
RefSeq - XM_006500847
RefSeq Peptide - NP_001335126
RefSeq Peptide - NP_780598
RefSeq Peptide - NP_001335125
swissprot - E9Q663
swissprot - A0A0R4J205
swissprot - E0CZ56
swissprot - E0CY61
Ensembl - ENSMUSG00000004127
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 trmt10aENSDARG00000036678Danio rerio
 TRMT10AENSGALG00000012264Gallus gallus
 Q8TBZ6ENSG00000145331Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9D075 / Trmt10b / tRNA methyltransferase 10 homolog B / Q6PF06* / tRNA methyltransferase 10B*ENSMUSG0000003560126
Q3UFY8 / Trmt10c / tRNA methyltransferase 10 homolog C / Q7L0Y3* / tRNA methyltransferase 10C, mitochondrial RNase P subunit*ENSMUSG0000004476320


Protein motifs (from Interpro)
Interpro ID Name
 IPR007356  tRNA (guanine-N1-)-methyltransferase, eukaryotic
 IPR014710  RmlC-like jelly roll fold
 IPR016009  tRNA methyltransferase TRMD/TRM10-type domain
 IPR016653  tRNA (guanine(9)-N(1))-methyltransferase TRM10/TRM10A
 IPR028564  tRNA methyltransferase TRM10-type domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0030488 tRNA methylation IEA
 biological_processGO:0032259 methylation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0015629 actin cytoskeleton IEA
 molecular_functionGO:0000049 tRNA binding IEA
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0009019 tRNA (guanine-N1-)-methyltransferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000183 decreased circulating LDL cholesterol level "less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Kmt5btm1a(KOMP)Wtsi/Kmt5btm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kmt5btm1a(KOMP)Wtsi/Wtsi

 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Kmt5btm1a(KOMP)Wtsi/Kmt5btm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kmt5btm1a(KOMP)Wtsi/Wtsi

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Kmt5btm1a(KOMP)Wtsi/Kmt5btm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kmt5btm1a(KOMP)Wtsi/Wtsi

 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: Kmt5btm1a(KOMP)Wtsi/Kmt5btm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kmt5btm1a(KOMP)Wtsi/Wtsi

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
Show

Allelic Composition: Kmt5btm1a(KOMP)Wtsi/Kmt5btm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kmt5btm1a(KOMP)Wtsi/Wtsi

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
Show

Allelic Composition: Kmt5btm1a(KOMP)Wtsi/Kmt5btm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kmt5btm1a(KOMP)Wtsi/Wtsi

 MP:0002942 decreased circulating alanine transaminase level "decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Kmt5btm1a(KOMP)Wtsi/Kmt5btm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kmt5btm1a(KOMP)Wtsi/Wtsi

 MP:0003443 increased circulating glycerol level "higher than normal concentration of glycerol in the blood" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Kmt5btm1a(KOMP)Wtsi/Kmt5btm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kmt5btm1a(KOMP)Wtsi/Wtsi

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Kmt5btm1a(KOMP)Wtsi/Kmt5btm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kmt5btm1a(KOMP)Wtsi/Wtsi

 MP:0005632 decreased circulating aspartate transaminase level "less than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Kmt5btm1a(KOMP)Wtsi/Kmt5btm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kmt5btm1a(KOMP)Wtsi/Wtsi

 MP:0010092 increased circulating magnesium level "an elevation in the blood concentration of magnesium" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Braftm1Mmcm/Braftm1Mmcm,Nkx3-1tm4(cre/ERT2)Mms/Nkx3-1+,Ptentm1Hwu/Pten+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0010101 increased sacral vertebrae number "increase of any or all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kmt5btm1a(KOMP)Wtsi/Kmt5btm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kmt5btm1a(KOMP)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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